The Business of Mass-Producing Vaccines

Dyadic CEO Discusses how his Company Could Expedite Vaccine Production

(Note: companies that
could be impacted by the content of this article are listed at the base of the
story [desktop version]. This article uses third-party references to provide a
bullish, bearish, and balanced point of view; sources are listed after the
Balanced section.)

In an interview, Dyadic CEO Mark Emalfarb told Trish Regan of FOX Business News that his company has the technology to allow them to mass-produce a vaccine should one get approved. “We developed the technology platform that we’ve been developing for years over two and half decades to make proteins at large scale, at very low cost,” Emalfarb said. Watch
Video

Market Selloffs and IRA Contributions

IRA Thoughts: When Market Selloffs and Tax Season Collide

It seemed too good to be true. For the past 13 months, day after day, the overall stock market continued to break new highs. Despite earthquakes in California, the longest federal government shutdown in history, a Special Prosecutor investigating the U.S. President, global economic malaise, trade wars, inverted yield curve fears, the manufacturing contraction, the vote to impeach, lower earnings guidance, and the military flare-up with Iran, the market shook it all off and set record-high after record-high.

Less than two weeks ago, all three major indices again recorded new highs. However, the intense double-digit market selloff that followed, substantially reduces the odds of a new all-time high in the coming months. The impetus for this continuing selloff is not part of normal economic/market rhythm. Instead, it is the reasonable expectation that there will be a global slowdown from reduced economic activities related to coronavirus. In highly populated areas of China, the world’s second-largest economy, activity (both production and consumption) are reported to have come to a crawl. Other countries have taken drastic measures as well. Japan has gone as far as keeping kids home from school.

Investors Versus Traders

For long-term investors, the Nasdaq is up 28.21%%, the Dow has earned 8.80%, and the S&P is up 16.65% since January 1, 2019. This hardly seems worth worrying about. For shorter-term investors or  traders, their entry may not leave them with the positive returns achieved over the past 13 ½ months. If they got in at the beginning of this year, they were confronted with forces that pushed the Nasdaq down 5.81%, the Dow down 12.04%, and S&P down 9.93%. The market declines are even higher for those entering since last Friday. Last week (a/o 2:30pm Friday), the declines are 12.56% for the Dow 30, 11.62% for the Nasdaq, and 12.07% for the S&P 500.

For those investing for future retirement, (not traders) with a longer-term horizon than those that have been looking for short-term gains, congratulations, stocks are still only 12.08% off their all-time highs. That isn’t all that bad if you participated in the run-up.

Current IRA Position

The above-average return of stocks, even after the sell-off, does not answer the question, “what do I do now?” More importantly, it doesn’t answer what to do with a new (2019 tax-year) contribution to your Roth or traditional IRA.

For existing assets, the wisdom of periodic rebalancing to bring the percent in various market classes back to the original plan’s allocation is based on sound reasoning. If a plan allocation calls for 50% equity, 40% fixed income, 5% real estate, and 5% cash with a quarterly rebalancing, the recent market moves should not change the plan. In practice, it is times such as the current “black swan event” that is the reason the risk/reward allocation with a periodic rebalance is being used.

In the past week, the fixed income portion of your portfolio has rallied dramatically. The entire yield curve is below the announced Federal Reserve’s targets. Benchmark bonds, such as the 10-year Treasury note are at their all-time most expensive levels. With this, it’s likely your allocation has exceeded 40% in this class. Your 50% equity allocation is likely lower than targetted in conjunction with your equity holdings. Real estate, particularly hotel REITs took less of a hit than most stocks, but are down as well.

A scheduled portfolio rebalancing would have assets moved automatically to this real estate position.  With lowered interest rates, REITs should do better once the “dump everything” madness settles down. So a reallocation back to real estate investments would seem prudent. Dividend-paying REITs should gain investor attention as other market interest rates are miniscule. Lower interest rates also tend to add demand to the heavily financed real estate sector.  So, low rates could add capital gains growth to real estate holdings going forward. Reallocating assets into the equity portion of the portfolio may be uncomfortable after such a harsh market turn. Keeping in mind the history of black swan events that have caused crashes, and the remember that the equity markets have since those events broken new highs, is a good reminder that we have always recovered in the past. In fact, after September 11, 2001, the markets recovered fully in less than 30 days after they reopened. The wisdom of rebalancing to the original strategy also forces you to sell and take profits in sectors that may not have much further to run. With interest rates at all-time lows (prices high), they may not have much more room to move in your favor. Selling expensive bonds and buying stocks that are relatively cheap is part of the rebalancing and makes sense.

The reason most advisors schedule rebalancing to the original allocation strategy is to take emotion and timing out of the decision to add to the sector that has been weakest and therefore could be cheap. If you have been managing your portfolio with scheduled rebalancing, nothing has changed to suggest you should deviate.

New Money

IRA assets are invested assets, not a trading account. The time horizon in almost all cases is longer than a year, and in most cases, much longer. Assuming there was an original strategic plan, there should not be any reason to deviate greatly from the plan. But, this may be a time to rethink how you are allocated within each class (Stocks, Bonds, RE). Not all securities within a class will react the same.

Within the Real Estate class, the sectors in which you place new money should be reviewed. Lodging and resort REITs have been particularly hard hit, whereas healthcare has outperformed. Self-storage has protected investors during economic downturns, infrastructure REITs are favorable during boom periods as are Timberland REITs. Diversifying within an asset class helps smooth out performance in any economic climate.

Moderation of large swings within fixed income is best attained by spreading the risk through both maturities and credit-quality. In all cases, the idea of a bond fund while rates are at their historic lows has a very low probability of success. Bond funds are valued based on the prices of the bonds within the portfolio. When interest rates rise off their lows, the prices of the bonds will go down. As the price goes down, so does the value of your bond fund. The same is true for individual bonds, but holders of the security, not the fund, can wait until the security matures (bond funds don’t mature, bonds do). When a holding matures, the owner will receive what they contracted to receive at purchase. This “known” return is what makes bonds appealing as an investment and bonds more attractive than bond funds when rates are below average.

Within the asset class of fixed income, investors for retirement may wish to invest relatively short-term (4 years or less). The difference between one-year Treasury rates at 1.18% and 10-year rates at 1.30% is small. So the idea of stretching your maturities longer would seem unfulfilling. As an alternative, lower quality corporate bonds offer higher rates. Investing in investment-grade notes (BBB- or higher) will add additional yield.

For the stock market portion of your “new money,” you could consider diversifying based on the current state of the market and expectations once this health crisis passes. What sectors within the class have been beaten down the most and expected to rebound (energy, travel, tourism, etc.)? What sectors did best during the crisis (health, biotech, consumer goods)? How will you diversify to reap the benefits of the next market jolt? Would you benefit from owning stocks where you can sell the most at risk and hold the best next time an unforeseen event happens? Individual stock purchases through most brokers are now typically less expensive than mutual funds. There is plenty of informed research to determine the fit of specific names. This research and analysis is available through both brokerage houses and companies like Morningstar and service like Channelchek.

One lesson investors have learned through this recent route is that diversifying through multiple index funds may be a false sense of security. Your exposure to a few hard hit companies may be greater than realized.  If a company like Apple or Microsoft make up a high percentage of each of the indices in which you’ve invested you could have deeper losses than you may otherwise have had if you had not been as exposed.

Perfect Information

Where the virus is going, we don’t know. The past is no guarantee of future returns, but we have survived through worse and then seen the markets set new highs sooner than we ever thought possible.  I’ve heard a lot of “buy the dip” talk. If everyone was buying the dip, there would be no dip. So listen with skepticism and with an eye toward who is suggesting this. Are they politically motivated, profit-motivated, or a trusted source with your best interests in mind? If you’re uncomfortable with fully investing your new IRA contribution all at once in a market that may continue downward, you may want to place these new savings into a money market fund and have a sixth moved into the market at even increments on the same day each month. i.e., a $6,000 IRA contribution, then move $1,000 into a balanced fund every second Monday for six months.

Retirement money is a long-term investment. Bumps in the road are uncomfortable, but if you’re years from needing the assets, invest in a way that will most likely net you the most while tempering the rough ride.

Suggested
Reading:

Black
Swans, Falling Knives, and Market Corrections

The Market and Management Seem to be at
Odds on Earnings Projections

 

Sources:

Stock Market News For
Dec 31, 2018

These Were The Biggest
News Stories In 2019, According To Google

Research – Orion Group Holdings (ORN) — Set Up for Positive Year Drives Higher Price Target

Monday, March 2, 2020

Orion Group Holdings (ORN)

Set Up for Positive Year Drives Higher Price Target

Orion Group Holdings, based in Houston, Texas, is a specialty construction company within the Marine and Industrial Construction sectors, with operations focused in the continental United States and Caribbean. Revenue is split roughly 50/50 between a Marine Construction segment that provides marine facility, pipeline and structural construction services and a Commercial Concrete segment that provides turnkey concrete services in the light commercial and structural construction markets.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

A solid end to a transformational year. 4Q2019 gross profit of $19.1 million and EBITDA of $11.0 million beat our estimates of $15.2 million and $8.2 million, respectively. High backlog, improving execution and ISG restructuring create tailwinds into 2020.

YE2019 backlog moderated to $572 million, as expected, but still up 30% over YE2018 and industry fundamentals remain positive. Backlog is $341 million in Marine and $232 million in…



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Research – E.W. Scripps Company (SSP) – A Political Boost

Monday, March 2, 2020

E.W. Scripps Company (SSP)

A Political Boost

The E.W. Scripps Co. (www.scripps.com) serves audiences and businesses through a growing portfolio of television, print and digital media brands. After approval of its acquisition of two Granite Broadcasting stations later this year, Scripps will own 21 local television stations as well as daily newspapers in 13 markets across the United States. It also runs an expanding collection of local and national digital journalism and information businesses including digital video news service Newsy. Scripps also produces television programming, runs an award-winning investigative reporting newsroom in Washington, D.C., and serves as the longtime steward of one of the nation�s largest, most successful and longest-running educational programs, Scripps National Spelling Bee. Founded in 1879, Scripps is focused on the stories of tomorrow.

Michael Kupinski, Director of Research, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Q4 Outperforms. Total company revenues of $444.4 million were better than our $420.0 million estimate on better-than-expected Political ($15.2 million versus our $11.0 million estimate). Cash flow was $10 million better than our estimate.

Q1 expense outlook stronger than expected. The company indicated that network comp escalators and news programming investments will restrain…



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Research gray television inc- gtn why we are raising our price target

Friday, February 28, 2020

Gray Television Inc. (GTN)

Why We Are Raising Our Price Target

Gray Television, Inc. operates as a television broadcast company in the United States. As of April 6, 2010, it operated 36 television stations in 30 markets, including 17 affiliated with CBS Inc.; 10 affiliated with the National Broadcasting Company, Inc.; 8 affiliated with the American Broadcasting Company (ABC); and 1 affiliated with FOX Entertainment Group, Inc. (FOX). The company also operated 39 digital second channels comprising 1 affiliated with ABC, 4 affiliated with FOX, 7 affiliated with CW Network, LLC, 18 affiliated with Twentieth Television, Inc., 2 affiliated with Universal Sports Network, and 7 local news/weather channels. Gray Television, Inc. was founded in 1897 and is headquartered in Atlanta, Georgia.

Michael kupinski, Director of Research, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Exceeds Q4 expectations. Q4 revenues of $579.0 million was better than our $553.0 million estimate on the strength of Political advertising ($35.0 million versus our $26.0 million estimate). Cash flow was $215.0 million, better than our $193.0 million estimate.

Political is a barn-burner. Guidance for high margin, Political advertising for the first quarter of $35 mil to $40 mil is better than our $30 mil estimate. The company raised its full year Political guidance to a range of $250 mil to $275 mil, which, we believe, may prove to be…



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Research – Gray Television Inc. (GTN) – Why We Are Raising Our Price Target

Friday, February 28, 2020

Gray Television Inc. (GTN)

Why We Are Raising Our Price Target

Gray Television, Inc. operates as a television broadcast company in the United States. As of April 6, 2010, it operated 36 television stations in 30 markets, including 17 affiliated with CBS Inc.; 10 affiliated with the National Broadcasting Company, Inc.; 8 affiliated with the American Broadcasting Company (ABC); and 1 affiliated with FOX Entertainment Group, Inc. (FOX). The company also operated 39 digital second channels comprising 1 affiliated with ABC, 4 affiliated with FOX, 7 affiliated with CW Network, LLC, 18 affiliated with Twentieth Television, Inc., 2 affiliated with Universal Sports Network, and 7 local news/weather channels. Gray Television, Inc. was founded in 1897 and is headquartered in Atlanta, Georgia.

Michael kupinski, Director of Research, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Exceeds Q4 expectations. Q4 revenues of $579.0 million was better than our $553.0 million estimate on the strength of Political advertising ($35.0 million versus our $26.0 million estimate). Cash flow was $215.0 million, better than our $193.0 million estimate.

Political is a barn-burner. Guidance for high margin, Political advertising for the first quarter of $35 mil to $40 mil is better than our $30 mil estimate. The company raised its full year Political guidance to a range of $250 mil to $275 mil, which, we believe, may prove to be…



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Research orion group holdings orn better than expected 4q2019 results and positive 2020 ebitda guidance

Thursday, February 27, 2020

Orion Group Holdings (ORN)

Better than expected 4Q2019 Results and Positive 2020 EBITDA Guidance

Orion Group Holdings, based in Houston, Texas, is a specialty construction company within the Marine and Industrial Construction sectors, with operations focused in the continental United States and Caribbean. Revenue is split roughly 50/50 between a Marine Construction segment that provides marine facility, pipeline and structural construction services and a Commercial Concrete segment that provides turnkey concrete services in the light commercial and structural construction markets.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

4Q2019 gross profit of $19.1 million and EBITDA of $11.0 million beat our estimates of $15.2 million and $8.2 million, respectively. Gross margin of 9.6% was in line and EBITDA margin of 5.5% was ~400 basis points higher. Main driver was Marine profitability and Concrete has plenty of room to improve. Positive 2020 EBITDA guidance in the low-mid $40 million range is slightly above our $41.1 million estimate.

YE2019 backlog moderated to $572 million, as expected, but still up 30% over YE2018 and industry fundamentals remain positive. YTD awards total $87 million ($47 million in industrial and $40 million in concrete), and…



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Research tribune publishing company tpco further consolidation appears likely

Thursday, February 27, 2020

Tribune Publishing Company (TPCO)

Further Consolidation Appears Likely

Tribune Publishing Co is a print and online media company that publishes various newspapers and websites. It creates and distribute content across its media portfolio, offering integrated marketing, media, and business services to consumers and advertisers, including digital solutions and advertising opportunities. The company manages its business as two distinct segments, M and X. Segment M is comprised of the company’s media groups excluding their digital revenues and related digital expenses, except digital subscription revenues when bundled with a print subscription. Segment X includes the company’s digital revenues and related digital expenses from local Tribune websites, third party websites, mobile applications, digital only subscriptions, Tribune Content Agency and BestReviews.

Michael Kupinski, DOR, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Quarterly preview. We anticipate that the company will meet our adjusted EBITDA estimate for Q4. The company will report its fourth quarter and full year 2019 results on March 4, 2020.

Noble conference highlights. This report highlights a fireside chat with Terry Jimenez, CEO, at Noble’s 16th annual equity conference held February 19th at the Hard Rock Hotel in…


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Research – Orion Group Holdings (ORN) – Better than expected 4Q2019 Results and Positive 2020 EBITDA Guidance

Thursday, February 27, 2020

Orion Group Holdings (ORN)

Better than expected 4Q2019 Results and Positive 2020 EBITDA Guidance

Orion Group Holdings, based in Houston, Texas, is a specialty construction company within the Marine and Industrial Construction sectors, with operations focused in the continental United States and Caribbean. Revenue is split roughly 50/50 between a Marine Construction segment that provides marine facility, pipeline and structural construction services and a Commercial Concrete segment that provides turnkey concrete services in the light commercial and structural construction markets.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

4Q2019 gross profit of $19.1 million and EBITDA of $11.0 million beat our estimates of $15.2 million and $8.2 million, respectively. Gross margin of 9.6% was in line and EBITDA margin of 5.5% was ~400 basis points higher. Main driver was Marine profitability and Concrete has plenty of room to improve. Positive 2020 EBITDA guidance in the low-mid $40 million range is slightly above our $41.1 million estimate.

YE2019 backlog moderated to $572 million, as expected, but still up 30% over YE2018 and industry fundamentals remain positive. YTD awards total $87 million ($47 million in industrial and $40 million in concrete), and…



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Research – Tribune Publishing Company (TPCO) – Further Consolidation Appears Likely

Thursday, February 27, 2020

Tribune Publishing Company (TPCO)

Further Consolidation Appears Likely

Tribune Publishing Co is a print and online media company that publishes various newspapers and websites. It creates and distribute content across its media portfolio, offering integrated marketing, media, and business services to consumers and advertisers, including digital solutions and advertising opportunities. The company manages its business as two distinct segments, M and X. Segment M is comprised of the company’s media groups excluding their digital revenues and related digital expenses, except digital subscription revenues when bundled with a print subscription. Segment X includes the company’s digital revenues and related digital expenses from local Tribune websites, third party websites, mobile applications, digital only subscriptions, Tribune Content Agency and BestReviews.

Michael Kupinski, DOR, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Quarterly preview. We anticipate that the company will meet our adjusted EBITDA estimate for Q4. The company will report its fourth quarter and full year 2019 results on March 4, 2020.

Noble conference highlights. This report highlights a fireside chat with Terry Jimenez, CEO, at Noble’s 16th annual equity conference held February 19th at the Hard Rock Hotel in…


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Research – Dyadic International Inc. (DYAI) – Progress and Efforts Continues to Validate C1 Platform

Wednesday, February 26, 2020

Dyadic International Inc. (DYAI)

Progress and Efforts Continues to Validate C1 Platform

Dyadic International, Inc. is a global biotechnology company which is developing what it believes will be a potentially significant biopharmaceutical gene expression platform based on the industrially proven hyper productive engineered fungus Thermothelomyces heterothallica (formerly Myceliophthora thermophila), named C1.
The C1 microorganism, which enables the development and large scale manufacture of low cost proteins, has the potential to be further developed into a safe and efficient expression system that may help speed up the development, lower production costs and improve the performance of biologic vaccines and drugs at flexible commercial scales. Dyadic is using the C1 technology and other technologies to conduct research, development and commercial activities for the development and manufacturing of human and animal vaccines and drugs, such as virus like particles (VLPs) and antigens, monoclonal antibodies, Fab antibody fragments, Fc-Fusion proteins, biosimilars and/or biobetters, and other therapeutic proteins. Dyadic pursues research and development collaborations, licensing arrangements and other commercial opportunities with its partners and collaborators to leverage the value and benefits of these technologies in development and manufacture of biopharmaceuticals. In particular, as the aging population grows in developed and undeveloped countries, Dyadic believes the C1 technology may help bring biologic vaccines, drugs and other biologic products to market faster, in greater volumes, at lower cost, and with new properties to drug developers and manufacturers, and improve access and cost to patients and the healthcare system, but most importantly save lives.

Ahu Demir, Ph.D., Biotechnology Research Analyst, Noble Capital Markets, Inc.

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Dyadic is progressing towards generating human-like glycosylation by C1 platform. Dyadic ’s research partner VTT Technical Research Centre of Finland made further progress in glycoengineering by expressing another human-like glycan (G2). The company currently generated two (G0 and G2) of the four targeted mammalian glycans (Exhibit 1).

Glycosylation is key in bioproduction. Glycosylation refers to adding a carbohydrate to a protein. Majority of biologics (over 50%) are glycosylated including antibodies and cytokines. Glycans have marked effects on therapeutic efficacy, immunogenicity, protein stability, moderation of half-life of proteins. Therefore, glycoengineering is crucial in drug development. On the way to validate C1 technology in bioproduction, glycoengineering to produce…



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Research – Endeavour Silver Corp (EXK) – Lowering Estimates for 2020; Rating Reset to Market Perform

Wednesday, February 26, 2020

Endeavour Silver Corp (EXK)

Lowering Estimates for 2020; Rating Reset to Market Perform

Endeavour Silver Corp is a precious metal mining company. The company is primarily engaged in silver mining and owns three high-grade, underground, silver-gold mines in Mexico. Its other business activities include acquisition, exploration, development, extraction, processing, refining and reclamation. The company is organized into four operating mining segments, Guanacevi, Bolanitos, El Cubo, and El Compas, which are located in Mexico as well as Exploration and Corporate segments. Its Exploration segment consists of projects in the exploration and evaluation phases in Mexico and Chile.

Mark Reichman, Senior Research Analyst of Natural Resources, Noble Capital Markets, Inc.

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EXK reports fourth quarter and full year earnings. EXK reported a full year net loss of $48.1 million, or ($0.36) per share, compared to our forecast of a loss of $37.8 million, or ($0.28) per share. The company reported a fourth quarter loss of $17.9 million, or ($0.13) per share, compared to our estimate of a loss of $7.6 million, or ($0.05) per share. While revenue exceeded our forecast, cost of sales and expenses were above our estimates.

Updating estimates. We have reduced our 2020 and 2021 EPS estimates to $0.01 and $0.05 from $0.04 and and $0.06, respectively. We forecast 2020 and 2021 EBITDA of $34.1 million and $42.0 million, respectively. Our revised 2020 estimates reflect more gradual operational improvement at the Bolanitos mine and…



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Research – Genco Shipping & Trading Limited (GNK) – Solid Quarter and Expanding Fleet Renewal Program

Wednesday, February 26, 2020

Genco Shipping & Trading Limited (GNK)

Solid Quarter and Expanding Fleet Renewal Program

Genco Shipping & Trading Limited, incorporated on September 27, 2004, transports iron ore, coal, grain, steel products and other drybulk cargoes along shipping routes through the ownership and operation of drybulk carrier vessels. The Company is engaged in the ocean transportation of drybulk cargoes around the world through the ownership and operation of drybulk carrier vessels. As of December 31, 2016, its fleet consisted of 61 drybulk carriers, including 13 Capesize, six Panamax, four Ultramax, 21 Supramax, two Handymax and 15 Handysize drybulk carriers, with an aggregate carrying capacity of approximately 4,735,000 deadweight tons (dwt). Of the vessels in its fleet, 15 are on spot market-related time charters, and 27 are on fixed-rate time charter contracts. As of December 31, 2016, additionally, 19 of the vessels in its fleet were operating in vessel pools.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Adjusted 4Q2019 EBITDA of $28.4 million is below our estimate of $31.5 million, mainly due to lower than expected TCE rates of $12.6k/day. Management call today at 8:30am EST to discuss outlook. Call number is 334-777-6978 and code is 7774363.

Fine-tuning 2020 EBITDA estimate to $108.2 million based on dry bulk market weakness and smaller fleet. Forward cover of 79% of 1Q2020 days booked at $10.9k/day tempers current weakness. Cape cover looks very good at 78% of 1Q2020 days booked at $17.1k/day but EBITDA likely to be weaker in 2Q2020. Scrubbers on Capes and…




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