Dow Plunges 800 Points as Market Sell-Off Escalates

Key Points:
– The Dow fell 805 points, with a two-day loss exceeding 1,200 points, while the S&P 500 and Nasdaq also declined.
– Economic data signaled weaker consumer sentiment, a slowing housing market, and increased inflation concerns.
– Investors moved toward safer assets, boosting bonds and defensive stocks, while major indexes fell below key technical levels.

Stocks sold off on Friday as new U.S. economic data raised investor concerns over slowing growth and persistent inflation. The Dow Jones Industrial Average tumbled 805 points, or 1.8%, bringing its two-day losses to more than 1,200 points. The S&P 500 fell 1.6%, while the Nasdaq Composite dropped over 2% as investors moved away from equities in search of safer assets.

United Health led the Dow’s decline, plunging 7% following a Wall Street Journal report that the insurer is under investigation by the Justice Department. The stock was on track for its worst day since March 2020. Meanwhile, broader economic indicators pointed to growing uncertainty. The University of Michigan consumer sentiment index fell to 64.7 in January, a sharper decline than expected, reflecting rising inflation concerns. Additionally, the 5-year inflation outlook in the survey hit 3.5%, its highest level since 1995.

Housing market data also contributed to the negative sentiment, with existing home sales dropping more than anticipated to 4.08 million units. The U.S. services purchasing managers index (PMI) also showed signs of weakness, slipping into contraction territory for February. These factors compounded fears that economic conditions may not be as strong as previously believed.

Investors sought refuge in traditionally defensive assets. The benchmark 10-year Treasury note yield declined by 8 basis points to 4.418%, boosting bond prices. The Japanese yen also strengthened against the U.S. dollar. Defensive stocks, including Procter & Gamble, General Mills, Kraft Heinz, and Mondelez, posted gains as investors shifted toward more stable sectors.

Market weakness extended across the week, with the S&P 500 down about 1%, the Dow shedding 2%, and the Nasdaq losing 1.6%. Several factors weighed on stocks, including Walmart’s weaker-than-expected earnings guidance, which sent its stock down 3% on Friday and more than 9% for the week. Inflation concerns and losses in Palantir further pressured the market.

Technical indicators added to the cautious outlook. The Dow and Nasdaq both fell below their 50-day moving averages in afternoon trading. The Dow, down 1.8%, slipped under its 50-day average of 43,695.91 for the first time since Jan. 21, while the Nasdaq, down 2%, dropped below 19,686.10, marking its first break of that level since Feb. 12.

As investors brace for more potential volatility, the focus remains on upcoming economic data and policy developments. With inflationary pressures persisting and uncertainty surrounding future policy decisions, the market’s direction remains uncertain heading into next week.

Release – Nutriband Receives Certificate of Registration for Trademark covering Pharmaceutical and Product Research and Development

Research News and Market Data on NTRB

February 21, 2025 07:00 ET 

ORLANDO, Fla., Feb. 21, 2025 (GLOBE NEWSWIRE) — Nutriband Inc. (NASDAQ: NTRB) (NASDAQ:NTRBW), a developer of transdermal pharmaceutical products, today announced that it received the Certificate of Registration from the United States Patent and Trademark Office (USPTO) on Feb 18, 2025, for trademark registration Number 7,692,920, covering the mark “Nutriband™.” The Trademark registration covers Goods/Services: Class: 042 Product research and development, scientific research and development; biochemical research and development; pharmaceutical research and development.

The Nutriband™ trademark is integral to the commercialization of the Company’s platform technology AVERSA which can be incorporated into transdermal patches to prevent the abuse, diversion, misuse, and accidental exposure of drugs with abuse potential. Nutriband’s lead product under development is AVERSA™ Fentanyl, an abuse deterrent fentanyl transdermal system.

Nutriband, in partnership with Kindeva Drug Delivery, is progressing towards completing the scale-up of the commercial manufacturing process for AVERSA™ Fentanyl, the first product under the AVERSA Platform that the company intends to submit for FDA approval.

According to a market analysis report by Health Advances, AVERSA™ Fentanyl has the potential to reach peak annual U.S. sales of $80 million to $200 million. This reflects the significant impact that AVERSA™ technology could have on the market for abuse deterrent pharmaceutical products.

About AVERSA™ Technology

Nutriband’s AVERSA™ abuse deterrent transdermal technology is designed to incorporate aversive agents into transdermal patches, deterring abuse by making the experience unpleasant. This technology is especially significant for drugs like fentanyl, which have a high potential for abuse. AVERSA™ aims to ensure that these essential medications remain accessible to patients who need them while enhancing their safety profiles. The AVERSA™ technology is supported by a robust intellectual property portfolio, with patents granted in the United States and several other countries including Europe, Japan, Korea, Russia, Canada, Mexico, and Australia.

About Nutriband Inc.

Nutriband Inc. is primarily engaged in developing a portfolio of transdermal pharmaceutical products. The Company’s lead product in development is an abuse deterrent fentanyl patch that incorporates AVERSA™ technology. This technology can be integrated into any transdermal patch to prevent the abuse, misuse, diversion, and accidental exposure of drugs with abuse potential.

The Company’s website is www.nutriband.com. Any material contained in or derived from the Company’s websites, or any other website is not part of this press release.

Forward-Looking Statements

Certain statements contained in this press release, including, without limitation, statements containing the words ‘’believes,” “anticipates,” “expects” and words of similar import, constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements involve both known and unknown risks and uncertainties. The Company’s actual results may differ materially from those anticipated in its forward-looking statements as a result of a number of factors, including those including the Company’s ability to develop its proposed abuse deterrent fentanyl transdermal system and other proposed products, its ability to obtain patent protection for its abuse technology, its ability to obtain the necessary financing to develop products and conduct the necessary clinical testing, its ability to obtain Federal Food and Drug Administration approval to market any product it may develop in the United States and to obtain any other regulatory approval necessary to market any product in other countries, including countries in Europe, its ability to market any product it may develop, its ability to create, sustain, manage or forecast its growth; its ability to attract and retain key personnel; changes in the Company’s business strategy or development plans; competition; business disruptions; adverse publicity and international, national and local general economic and market conditions and risks generally associated with an undercapitalized developing company, as well as the risks contained under “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in the Company’s Form S-1, Form 10-K for the year ended January 31, 2024 and Forms 10-Q, and the Company’s other filings with the Securities and Exchange Commission. Except as required by applicable law, we undertake no obligation to revise or update any forward-looking statements to reflect any event or circumstance that may arise after the date hereof.

For more information, contact:

Nutriband Inc.
Phone: 407-377-6695
Email: info@nutriband.com

Celsius Acquires Alani Nutrition in $1.8 Billion Deal

Key Points:
– Celsius acquires Alani Nutrition in a $1.8 billion deal, expected to close in Q2 2025.
– The merger aims to create a leading functional beverage platform, catering to growing demand for zero-sugar alternatives.
– Celsius projects $2 billion in sales post-acquisition, with $50 million in cost synergies over two years.

Celsius Holdings has announced plans to acquire Alani Nutrition in a landmark $1.8 billion deal, marking a major consolidation in the U.S. energy drink market. The agreement, expected to be finalized in the second quarter of 2025, includes a net purchase price of $1.65 billion and $150 million in tax assets.

Alani Nutrition, founded in 2018, has built a reputation as a “female-focused” brand offering functional beverages and snacks tailored to Gen Z and millennial consumers. The Kentucky-based company, previously operated by Congo Brands, produces energy drinks, protein shakes, snacks, and protein powders. The acquisition will transfer ownership from co-founders Katy and Haydn Schneider, as well as Congo Brands’ co-founders Max Clemons and Trey Steiger, to Celsius Holdings.

Celsius believes the deal will create a powerful synergy, forming a “leading better-for-you, functional lifestyle platform.” By integrating Alani Nu’s products, Celsius aims to expand its reach in the functional beverage space and tap into growing demand for zero-sugar alternatives. The company expects the merger to drive approximately $2 billion in sales, leveraging the combined distribution networks, brand awareness, and innovation capabilities of both entities.

John Fieldly, Chairman and CEO of Celsius, highlighted the strategic benefits of the acquisition, stating that it will “broaden the availability of Alani Nu’s functional products” and strengthen the company’s presence in new market segments. The transaction is projected to be accretive to cash earnings per share (EPS) within the first full year of ownership, with an estimated $50 million in cost synergies to be realized over two years post-closing.

Max Clemons of Congo Brands expressed confidence in the deal, emphasizing that Celsius will “unlock key growth opportunities” for Alani Nu, particularly in expanding its distribution and consumer engagement.

The acquisition announcement coincided with Celsius reporting its fourth-quarter and full-year financial results for 2024. The company posted annual revenue of $1.36 billion, reflecting a 3% increase over the prior year. North American sales accounted for $1.28 billion, growing by 1%, while international revenues surged 37% to $74.7 million. Despite the revenue growth, Celsius experienced a decline in profitability, with adjusted EBITDA down 13% to $255.7 million and net profit falling 36% to $145.1 million.

Industry analysts view this acquisition as a strategic move that could help Celsius regain momentum in a highly competitive market. By capitalizing on Alani Nu’s strong brand presence and consumer loyalty, Celsius aims to solidify its position as a leader in the energy and functional beverage sector. The deal also signals an increasing trend of consolidation in the market, as major players look to expand their portfolios to meet shifting consumer preferences.

As the acquisition moves forward, investors and industry watchers will closely monitor how Celsius integrates Alani Nu into its operations and whether the expected synergies materialize. If successful, the merger could serve as a blueprint for future partnerships in the rapidly evolving health and wellness beverage industry.

Release – GDEV Declares One-Time, Nonrecurring Special Cash Dividend of $3.31 Per Share

Research News and Market Data on GDEV

February 21, 2025 08:00 ET 

LIMASSOL, Cyprus, Feb. 21, 2025 (GLOBE NEWSWIRE) — GDEV Inc. (Nasdaq: GDEV), an international gaming and entertainment company (“GDEV” or the “Company”), today announced that its Board of Directors has authorized and approved a one-time, nonrecurring special cash dividend of $3.31 per share, representing a yield of approximately 20% based on the volume-weighted average price of the Company’s shares for the last 30 trading days prior to today’s announcement. The special dividend is payable on March 11, 2025, to the Company’s shareholders of record as of the close of business on March 3, 2025.

This one-time special dividend, totaling approximately $60 million, will be funded from GDEV’s accumulated profits over the past few years and represents a portion of the Company’s total cash balance of approximately $153 million1 (as of Q3 2024). The Company expects to release its audited results for the 2024 financial year around the end of the first quarter of 2025.

By distributing a portion of its retained earnings, GDEV better optimizes its capital structure, reducing excess liquidity and providing for a more lean and efficient operating model. This decision reflects the Company’s commitment to disciplined capital allocation and long-term value creation. The Board’s confidence in GDEV’s financial strength underscores its proactive approach to maintaining an optimal balance between stability and growth in the volatile environment. Importantly, this special dividend is a one-time distribution and does not establish a recurring dividend program. It is not anticipated that the GDEV’s Board of Directors will declare any further dividends in the foreseeable future.

GDEV Founder, CEO, and Chairman of the Board of Directors, Andrey Fadeev, stated: “The special dividend is the first in the Company’s history since our public listing. The decision to declare a special dividend underscores our commitment to delivering value to our shareholders while maintaining a strong financial position. Our robust balance sheet enables us to return capital to shareholders without compromising our ability to invest in the Company’s long-term growth. Following this distribution, GDEV will remain debt-free with a substantial cash balance providing financial stability and the continued development of both our existing portfolio and future initiatives.”

About GDEV Inc.
GDEV is a gaming and entertainment holding company, focused on development and growth of its franchise portfolio across various genres and platforms. With a diverse range of subsidiaries including Nexters and Cubic Games, among others, GDEV strives to create games that will inspire and engage millions of players for years to come. Its franchises, such as Hero Wars, Island Hoppers, Pixel Gun 3D and others have accumulated over 550 million installs and $2.5 billion of bookings worldwide. For more information, please visit www.gdev.inc.

Contacts:

Investor Relations
Roman Safiyulin | Chief Corporate Development Officer
investor@gdev.inc

Cautionary statement regarding forward-looking statements

Certain statements in this press release may constitute “forward-looking statements” for purposes of the federal securities laws. Such statements are based on current expectations that are subject to risks and uncertainties. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements.

The forward-looking statements contained in this press release are based on the Company’s current expectations and beliefs concerning future developments and their potential effects on the Company. There can be no assurance that future developments affecting the Company will be those that the Company has anticipated. Forward-looking statements involve a number of risks, uncertainties (some of which are beyond the Company’s control) or other assumptions. You should carefully consider the risks and uncertainties described in the “Risk Factors” section of the Company’s 2023 Annual Report on Form 20-F, filed by the Company on April 29, 2024, and other documents filed by the Company from time to time with the SEC. Should one or more of these risks or uncertainties materialize, or should any of the Company’s assumptions prove incorrect, actual results may vary in material respects from those projected in these forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and the Company undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws.

_______________________
1 Including the investments into high quality liquid securities.

Release – Ocugen to Host Conference Call on Wednesday, March 5, 2025 at 8:30 A.M. ET to Discuss Business Updates and Fourth Quarter and Full Year 2024 Financial Results

Research News and Market Data on OCGN

February 21, 2025

PDF Version

MALVERN, Pa., Feb. 21, 2025 (GLOBE NEWSWIRE) — Ocugen, Inc. (Ocugen or the Company) (NASDAQ: OCGN), a biotechnology company focused on discovering, developing, and commercializing novel gene and cell therapies, biologics, and vaccines, today announced that it will host a conference call and live webcast to discuss the Company’s fourth quarter and full year 2024 financial results and provide a business update at 8:30 a.m. ET on Wednesday, March 5, 2025.

Ocugen will issue a pre-market earnings announcement on the same day. Attendees are invited to participate on the call using the following details:

Dial-in Numbers: (800) 715-9871 for U.S. callers and (646) 307-1963 for international callers
Conference ID: 5045393
Webcast: Available on the events section of the Ocugen investor site.

A replay of the call and archived webcast will be available for approximately 45 days following the event on the Ocugen investor site.

About Ocugen, Inc.
Ocugen, Inc. is a biotechnology company focused on discovering, developing, and commercializing novel gene and cell therapies, biologics, and vaccines that improve health and offer hope for patients across the globe. We are making an impact on patient’s lives through courageous innovation—forging new scientific paths that harness our unique intellectual and human capital. Our breakthrough modifier gene therapy platform has the potential to treat multiple retinal diseases with a single product, and we are advancing research in infectious diseases to support public health and orthopedic diseases to address unmet medical needs. Discover more at www.ocugen.com and follow us on X and LinkedIn.

Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, which are subject to risks and uncertainties. We may, in some cases, use terms such as “predicts,” “believes,” “potential,” “proposed,” “continue,” “estimates,” “anticipates,” “expects,” “plans,” “intends,” “may,” “could,” “might,” “will,” “should,” or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Such statements are subject to numerous important factors, risks, and uncertainties that may cause actual events or results to differ materially from our current expectations. These and other risks and uncertainties are more fully described in our periodic filings with the Securities and Exchange Commission (SEC), including the risk factors described in the section entitled “Risk Factors” in the quarterly and annual reports that we file with the SEC. Any forward-looking statements that we make in this press release speak only as of the date of this press release. Except as required by law, we assume no obligation to update forward-looking statements contained in this press release whether as a result of new information, future events, or otherwise, after the date of this press release.

Contact:
Tiffany Hamilton
AVP, Head of Communications
Tiffany.Hamilton@ocugen.com 

Unicycive Therapeutics (UNCY) – OLC Shows Synergy With Alternative Potassium Binder


Friday, February 21, 2025

Robert LeBoyer, Senior Vice President, Equity Research Analyst, Biotechnology, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Pre-Clinical Study Shows Synergy With Tenapanor. Unicycive Therapeutics announced the results of an animal model study that tested its phosphate binder, OLC, or oxylanthanum carbonate, and tenapanor, a phosphate-control drug that works through a different mechanism than the phosphate binding drugs. The results showed OLC had a greater reduction than tenapanor, and the combination of both drugs given together had synergistic effects that were better than either drug given alone.

Study Design. Tenapanor (Xphozah, from Ardelyx) is a sodium/hydrogen exchanger 3 (NHE3) inhibitor that works through paracellular absorption. It is used in patients that do not respond to phosphate binders or do not tolerate them. The study, “Combination Oxylanthanum Carbonate and Tenapanor Lowers Urinary Phosphate Excretion in Rats,” was published in the American Nephrology Society’s journal Kidney360. It compared the two drugs against a control (delivery vehicle alone) in rats receiving a high phosphorus diet.


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*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision. 

InPlay Oil (IPOOF) – Transformative Acquisition of Pembina Cardium Oil Assets


Friday, February 21, 2025

InPlay Oil is a junior oil and gas exploration and production company with operations in Alberta focused on light oil production. The company operates long-lived, low-decline properties with drilling development and enhanced oil recovery potential as well as undeveloped lands with exploration possibilities. The common shares of InPlay trade on the Toronto Stock Exchange under the symbol IPO and the OTCQX Exchange under the symbol IPOOF.

Mark Reichman, Managing Director, Equity Research Analyst, Natural Resources, Noble Capital Markets, Inc.

Hans Baldau, Research Associate, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Transaction highlights. The acquisition appears to offer significant synergies and benefits to InPlay’s operations. InPlay’s production is expected to more than double to 18,750 boe/d from previous guidance of 8,650-9,150. Additionally, on a per share basis, 2025 adjusted funds flow (AFF) is expected to increase to C$204 million from previous guidance of C$69-75 million. Furthermore, the nature of the assets acquired is expected to enhance operational efficiencies to InPlay’s existing Pembina asset base by increasing the scale and contributing to lower decline, higher oil-weighting, and less capital-intensive production.


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Equity Research is available at no cost to Registered users of Channelchek. Not a Member? Click ‘Join’ to join the Channelchek Community. There is no cost to register, and we never collect credit card information.

This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision. 

Codere Online (CDRO) – Favorable Underlying Revenue Trends


Friday, February 21, 2025

Codere Online refers, collectively, to Codere Online Luxembourg, S.A. and its subsidiaries. Codere Online launched in 2014 as part of the renowned casino operator Codere Group. Codere Online offers online sports betting and online casino through its state-of-the art website and mobile application. Codere currently operates in its core markets of Spain, Italy, Mexico, Colombia, Panama and the City of Buenos Aires (Argentina). Codere Online’s online business is complemented by Codere Group’s physical presence throughout Latin America, forming the foundation of the leading omnichannel gaming and casino presence in the region.

Michael Kupinski, Director of Research, Equity Research Analyst, Digital, Media & Technology , Noble Capital Markets, Inc.

Jacob Mutchler, Research Associate, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Currency exchange impact. Q4 revenue of €52.6 million was roughly in line with our estimate of €55.0 million in spite of currency headwinds. Adj. EBITDA of €1.9 million was better than our estimate of €1.5 million, as illustrated in Figure #1 Q4 Results. Revenues would have been stronger if not for the depreciation of the Mexican Peso, down roughly 13.5% against the Euro. On a constant currency basis, revenue was up a strong 15% compared to reported growth of 5%.

NASDAQ extends deadline. The company’s auditor, Marcum, resigned unexpectedly in December, quickly replaced by MaloneBailey. Importantly, the company was able to present a plan to NASDAQ in its hearing on January 16 and was granted an extension until May 12 to file its 2023 annual report, the maximum extension allowed. The company intends to file within the extension deadline.


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Equity Research is available at no cost to Registered users of Channelchek. Not a Member? Click ‘Join’ to join the Channelchek Community. There is no cost to register, and we never collect credit card information.

This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision. 

Aurania Resources (AUIAF) – Take-Aways from the Kuri-Yawi IP Geophysical Survey


Friday, February 21, 2025

Mark Reichman, Managing Director, Equity Research Analyst, Natural Resources, Noble Capital Markets, Inc.

Hans Baldau, Research Associate, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Survey results. Data collected from the survey was used to generate a three-dimensional model of the ground’s resistivity and chargeability. Conductive and chargeability anomalies are geophysical signatures that can indicate the presence of gold mineralization. The survey returned two main chargeability vertical structures. Resistivity results highlighted different bodies of rock, or lithologic units, with a conductive sedimentary unit to the east and a resistive volcanic unit overlaying another conductive unit at depth.


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*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision. 

ACCO Brands (ACCO) – A Peak Into 4Q24 Results


Friday, February 21, 2025

ACCO Brands Corporation is one of the world’s largest designers, marketers and manufacturers of branded academic, consumer and business products. Our widely recognized brands include AT-A-GLANCE®, Esselte®, Five Star®, GBC®, Kensington®, Leitz®, Mead®, PowerA®, Quartet®, Rapid®, Rexel®, Swingline®, Tilibra®, and many others. Our products are sold in more than 100 countries around the world. More information about ACCO Brands, the Home of Great Brands Built by Great People, can be found at www.accobrands.com.

Joe Gomes, CFA, Managing Director, Equity Research Analyst, Generalist , Noble Capital Markets, Inc.

Joshua Zoepfel, Research Associate, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

4Q24. Fourth quarter sales and EPS were in line with expectations, excluding greater than anticipated foreign currency headwinds. ACCO experienced ongoing softer demand for certain office-related products and lower demand for back-to-school products in Brazil, partially offset by growth in the technology accessories categories. ACCO further increased its multi-year cost reduction program to $100 million of cumulative savings.

Details. Revenue of $448.1 million was down 8.3% y-o-y, with comp sales down 5.9% and adverse foreign exchange reducing sales by 2.4%. Adjusted operating income was $64.2 million versus $68.3 million last year. Adjusted net income was $37.5 million, and adjusted EPS was $0.39 for both 4Q24 and 4Q23.


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Equity Research is available at no cost to Registered users of Channelchek. Not a Member? Click ‘Join’ to join the Channelchek Community. There is no cost to register, and we never collect credit card information.

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Treasury Yields Fall Slightly as Investors Weigh Economic Data

Key Points:
– Treasury yields declined slightly as investors analyzed economic data and Trump’s proposed tariffs.
– Jobless claims came in higher than expected, signaling a potential softening in the labor market.
– Fed officials emphasized the need for further inflation progress before considering rate cuts.

U.S. Treasury yields edged lower on Thursday as investors assessed fresh economic data and the potential impact of U.S. President Donald Trump’s proposed tariffs. The 10-year Treasury yield declined more than 2 basis points to 4.507%, while the 2-year Treasury yield dropped 2.3 basis points to 4.253%. Yields move inversely to bond prices, meaning demand for Treasuries increased slightly as investors sought stability amid economic uncertainty.

One of the key economic reports influencing the bond market was the latest weekly initial jobless claims data, which showed 219,000 new claims for unemployment benefits in the week ending Feb. 15. This was slightly above the 215,000 claims economists had expected, signaling a modest cooling in the labor market. Investors also awaited the release of the Philadelphia Fed Manufacturing Index, an important measure of regional economic activity that could provide further insight into the strength of the U.S. economy.

At the same time, Federal Reserve officials were scheduled to speak throughout the day, offering additional perspectives on monetary policy. Among them, Fed Bank of Chicago President Austan Goolsbee and Fed Governor Adriana Kugler were expected to discuss economic conditions and the outlook for inflation. The market remained focused on any indications of future interest rate changes, particularly given the Federal Reserve’s cautious stance on inflation.

Another factor weighing on investor sentiment was Trump’s latest tariff proposal, which called for a 25% duty on key imports, including automobiles, pharmaceuticals, and semiconductors. The former president stated that these tariffs could increase significantly over time and potentially take effect as early as April 2. Investors closely monitored these developments, as trade policies can have broad economic implications, affecting corporate profitability, inflationary pressures, and overall market stability.

Meanwhile, the Federal Reserve’s recently released meeting minutes suggested that policymakers remain concerned about inflation risks. Officials emphasized that they would need to see sustained progress on inflation before considering additional interest rate cuts. They also noted that potential shifts in trade and immigration policies could create further economic uncertainty.

Bond markets reacted cautiously to these developments, with Treasury yields experiencing a slight decline as investors weighed the implications for future monetary policy. Lower yields often indicate increased investor demand for safe-haven assets, particularly when concerns about economic growth or inflation emerge.

As the economic landscape continues to evolve, market participants will closely watch upcoming data releases and Federal Reserve commentary for further indications of policy direction. The trajectory of interest rates remains a key focus, with investors balancing optimism about economic resilience against concerns over inflation and potential trade disruptions.

AstraZeneca Acquires FibroGen’s China Business for $160 Million, Expanding Presence in Anemia Market

Key Points:
– Acquiring FibroGen’s China operations for $160M secures rights to anemia drug roxadustat.
– The sale extends cash runway to 2027 and funds key drug development.
– Roxadustat leads in China, but faces generic competition and regulatory scrutiny.

AstraZeneca (AZN) has announced a $160 million acquisition of FibroGen’s (FGEN) China business, securing regional rights to the oral anemia drug roxadustat. This deal strengthens AstraZeneca’s footprint in the Chinese pharmaceutical market while providing FibroGen with a much-needed financial boost.

The relationship between AstraZeneca and FibroGen surrounding roxadustat dates back over a decade. Initially, AstraZeneca held broader rights to the HIF-PH inhibitor but returned control in the U.S. and select other markets last year. However, the company maintained an interest in China and South Korea, where the drug is marketed under the brand name Evrenzo.

With this acquisition, AstraZeneca will pay an enterprise value of $85 million, in addition to $75 million of net cash currently held by FibroGen’s Chinese operations. The transaction is expected to close in mid-2025, at which point FibroGen plans to use the proceeds to repay a term loan facility managed by Morgan Stanley Tactical Value, simplifying its capital structure.

For FibroGen, this sale represents a crucial financial lifeline. Entering 2024, the company held $121.1 million in cash and equivalents. The proceeds from this transaction, coupled with loan repayment, should extend FibroGen’s cash runway into 2027. The move allows the company to refocus on developing FG-3246, a CD46-targeting antibody-drug conjugate, and FG-3180, a companion PET imaging agent for metastatic castration-resistant prostate cancer (mCRPC).

“This deal bolsters our company on several fronts,” said FibroGen CEO Thane Wettig. “It strengthens our financial position, meaningfully extending our cash runway, and enables us to continue progressing key clinical development programs.”

Roxadustat is a leading treatment for anemia in chronic kidney disease in China, and regulatory bodies are considering its approval for chemotherapy-induced anemia. Despite its dominance, the drug faces increasing competition, as Chinese regulators approved a generic version from CSPC Pharmaceutical last summer. Several other companies are also seeking approval for their own generic versions.

China remains a crucial market for AstraZeneca, though the company has recently encountered challenges, including a slowdown in sales and an ongoing investigation into its former China head, Leon Wang, over potential tax violations. Nevertheless, AstraZeneca CEO Pascal Soriot remains optimistic, stating in a recent earnings call that “longer term, we see continuous opportunity for growth in China.”

While today’s deal secures AstraZeneca’s position in China, FibroGen retains the rights to roxadustat in other markets, including the U.S., where it has faced regulatory setbacks. The drug was rejected by the FDA in 2021 for chronic kidney disease and later failed a Phase 3 anemia trial in 2023. However, FibroGen is still evaluating development plans for anemia associated with lower-risk myelodysplastic syndrome, with hopes of meeting with the FDA in the second quarter to discuss potential next steps.

As the transaction moves forward, both AstraZeneca and FibroGen are positioning themselves for long-term growth, with AstraZeneca reinforcing its presence in China’s expanding pharmaceutical sector and FibroGen securing the resources to pursue future drug development.

Release – Direct Digital Holdings Introduces A New Framework to Help Businesses Manage AI Adoption in the Workplace

Research News and Market Data on DRCT

February 20, 2025 9:00 am EST Download as PDF

New guide helps organizations create clear, responsible AI usage policies to unlock the value of artificial intelligence while mitigating risks

HOUSTON, Feb. 20, 2025 /PRNewswire/ — Direct Digital Holdings, Inc. (Nasdaq: DRCT) (“Direct Digital Holdings” or the “Company”), a leading advertising and marketing technology platform operating through its companies Colossus Media, LLC (“Colossus SSP”) and Orange 142, LLC (“Orange 142”), today announced the release of its framework for establishing an employee generative AI usage policy, a practical guide from the company’s AI Council designed to help organizations set clear expectations and guardrails for AI use in the workplace.

As generative AI tools become more common in daily workflows, employees use them to streamline tasks, increase efficiency, and drive productivity. However, organizations risk data leaks, misinformation, compliance challenges, and reputational damage without well-defined policies. Despite widespread AI adoption, only 44% of companies have formal policies to govern its use.

Providing a Framework for AI Adoption and Governance

“AI adoption in the workplace is happening faster than many businesses are prepared for,” said  Anu Pillai, Chief Technology Officer at Direct Digital Holdings. “Employees are already using these tools, but companies are leaving themselves open to significant risks without clear guidelines. Our framework offers business leaders a starting point to create transparent, structured AI policies that allow teams to safely and securely take advantage of the technology’s benefits.”

The “Framework for Employee Generative AI Usage Policy” guide is designed to help organizations craft policies tailored to their needs, addressing:

  • Ethical AI use and transparency
  • When AI can be used to add value and when its use poses an unnecessary risk
  • Data privacy guidelines to protect sensitive information
  • Human review and decision-making as a last line of defense
  • Creating cyclic structures for evaluating and auditing AI tools to maintain security

“Businesses can’t afford to take a wait-and-see approach on AI governance,” said Christy Nolan, VP of Delivery Solutions at Direct Digital Holdings. “By setting clear guidelines now, companies can foster a culture of informed AI adoption, positioning themselves to stay competitive while maintaining trust with customers, partners, and stakeholders.”

The framework is a foundational resource for business leaders, IT teams, and compliance officers looking to implement AI usage policies aligning with their industry, regulatory requirements, and company goals. It is designed to help organizations stay agile as AI evolves, providing a roadmap for responsible and sustainable AI integration in the workplace.

To download the “Framework for Employee Generative AI Usage Policy,” visit our AI Council resource center.

About Direct Digital Holdings

Direct Digital Holdings (Nasdaq: DRCT) combines cutting-edge sell-side and buy-side advertising solutions, providing data-driven digital media strategies that enhance reach and performance for brands, agencies, and publishers of all sizes. Our sell-side platform, Colossus SSP, offers curated access to premium, growth-oriented media properties throughout the digital ecosystem. On the buy-side, Orange 142 delivers customized, audience-focused digital marketing and advertising solutions that enable mid-market and enterprise companies to achieve measurable results across a range of platforms, including programmatic, search, social, CTV, and influencer marketing. With extensive expertise in high-growth sectors such as Energy, Healthcare, Travel & Tourism, and Financial Services, our teams deliver performance strategies that connect brands with their ideal audiences. At Direct Digital Holdings we prioritize personal relationships by humanizing technology, ensuring each client receives dedicated support and tailored digital marketing solutions regardless of company size. This empowers everyone to thrive by generating billions of monthly impressions across display, CTV, in-app, and emerging media channels through advanced targeting, comprehensive data insights, and cross-platform activation. DDH is “Digital advertising built for everyone.”

Direct Digital Holdings Logo (PRNewsfoto/Direct Digital Holdings)

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SOURCE Direct Digital Holdings

Released February 20, 2025