Robert LeBoyer, Senior Vice President, Equity Research Analyst, Biotechnology, Noble Capital Markets, Inc.
Refer to the full report for the price target, fundamental analysis, and rating.
Progress On CAD-1005 Reported With FY2025 Results. Cadrenal reported a loss for 4Q25 of $3.0 million or $(1.42) per share and a FY2025 loss of $13.2 million or $(6.64) per share. Importantly, it recently held its End-Of-Phase 2 meeting with the FDA to receive guidance for the planned Phase 3 trial for CAD-1005 in HIT (heparin-induced thrombocytopenia). The company had cash and equivalents of $4.0 million on December 31, 2025.
Lead Indication Reported Phase 2 Data. As discussed in our Research Note on February 25, Cadrenal reported results from its Phase 2 study of CAD-1005 in HIT. The trial was designed to show CAD-1005 improved platelet recovery and tested platelet count recovery as a biomarker for thrombosis and outcome. The data did not show a correlation between platelet count normalization and thrombotic events, but did show an important reduction in thrombotic events exceeding 25% in the CAD-1005 treatment arm compared with placebo.
Equity Research is available at no cost to Registered users of Channelchek. Not a Member? Click ‘Join’ to join the Channelchek Community. There is no cost to register, and we never collect credit card information.
This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).
*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision.
Robert LeBoyer, Senior Vice President, Equity Research Analyst, Biotechnology, Noble Capital Markets, Inc.
Refer to the full report for the price target, fundamental analysis, and rating.
FY2025 Reported With PrimeC Progress Review. NeuroSense reported a loss for FY2025 of $11.1 million or $(0.44) per share. The company gave updates to its ongoing PrimeC development programs and expected milestones for the coming year in ALS and Alzheimer’s disease. As of December 31, 2025, NeuroSense had cash of approximately $0.2 million.
Phase 3 In ALS Has Received FDA Clearance. During November 2025, NeuroSense received FDA clearance to initiate the Phase 3 trial in ALS. The company has completed commercial-scale manufacturing and continues to prepare for the Phase 3 trial, which we expect to begin later in FY2026.
Equity Research is available at no cost to Registered users of Channelchek. Not a Member? Click ‘Join’ to join the Channelchek Community. There is no cost to register, and we never collect credit card information.
This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).
*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision.
Robert LeBoyer, Senior Vice President, Equity Research Analyst, Biotechnology, Noble Capital Markets, Inc.
Refer to the full report for the price target, fundamental analysis, and rating.
New Data Presented Shows Long-Term Survival. MAIA presented data from its Phase 2 THIO-101 trial at the European Lung Cancer Congress 2026 (ELCC) held recently in Copenhagen, Denmark. The presentation included data from patients with non-small cell lung cancer (NSCLC) who had relapsed after treatment with standard chemotherapy. Data from 8 patients showed survival exceeding 2 years and greatly exceeded the expected survival for patients at their stage of disease.
Phase 2 Trial Design. THIO-101 was designed in three stages. Part A was basic safety, and Part B was a dose-finding stage. These two stages treated a total of 79 patients. The ongoing Part C is an expansion stage enrolling up to 48 participants in Asia and Europe. The patients are treated with ateganosine (aka THIO) followed by cemiplimab (Libtayo, from Regeneron).
Equity Research is available at no cost to Registered users of Channelchek. Not a Member? Click ‘Join’ to join the Channelchek Community. There is no cost to register, and we never collect credit card information.
This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).
*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision.
Michael Kupinski, Director of Research, Equity Research Analyst, Digital, Media & Technology , Noble Capital Markets, Inc.
Jacob Mutchler, Research Associate, Noble Capital Markets, Inc.
Refer to the full report for the price target, fundamental analysis, and rating.
Results weaker than expected. Full year 2025 revenue of $361.9 million was well below our $434.2 million estimate. Management emphasized that the Medicare Advantage market remains in a structural reset heading into 2026, with carriers prioritizing retention, member quality, margin integrity, and disciplined unit economics over enrollment growth. Full year 2025 adj. EBITDA loss estimate of $35.1 million was more than our loss estimate of $29.6 million.
Strategic reset. The company has deliberately reduced Medicare Advantage enrollments where first-renewal economics were unattractive, prioritizing long-term profitability and appropriate consumer plan fit. At the same time, it has maintained leadership in Special Needs Plans (SNP), benefiting from carrier focus on high-need, high-retention populations.
Equity Research is available at no cost to Registered users of Channelchek. Not a Member? Click ‘Join’ to join the Channelchek Community. There is no cost to register, and we never collect credit card information.
This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).
*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision.
The FDA approved Eli Lilly’s (NYSE: LLY) Foundayo (orforglipron) today, a once-daily oral GLP-1 receptor agonist for adults with obesity or overweight with weight-related medical conditions. The approval marks a pivotal shift in one of the fastest-growing drug categories in history — and for small and microcap investors, the ripple effects are worth paying close attention to.
Foundayo joins Novo Nordisk’s Wegovy pill as the only two oral GLP-1 medications with FDA approval, but Lilly is positioning its drug as the more flexible option. Unlike the Wegovy pill, which must be taken in the morning 30 minutes before eating or drinking, Foundayo can be taken at any time of day and without restrictions on food and water.
It’s worth noting that Lilly is having one of the busiest 24-hour stretches in recent memory. Yesterday, the company announced a definitive agreement to acquire Centessa Pharmaceuticals for up to $47.00 per share — a deal valued at approximately $7.8 billion — to bolster its neuroscience pipeline in sleep-wake disorders. [Related: Eli Lilly Banks $6.3 Billion on Sleep Science with Centessa Pharmaceuticals Acquisition]Today’s FDA approval underscores just how aggressively Lilly is moving across multiple therapeutic fronts simultaneously.
The Numbers Behind the Pill
In the ATTAIN-1 trial, patients receiving the highest dose who remained on treatment lost a mean of 27.3 pounds (12.4%) compared with 2.2 pounds (0.9%) among those receiving placebo. That’s meaningfully below the 20%+ weight loss seen with injectable GLP-1s like Zepbound, but Lilly isn’t positioning this as a replacement — it’s positioning it as an on-ramp.
Analysts estimate Foundayo sales will reach $14.79 billion by 2030, compared to expectations of $24.68 billion for Zepbound. On pricing, eligible people with commercial insurance may pay as little as $25 per month, self-pay patients can access it starting at $149 per month, and eligible Medicare Part D patients may access it for $50 per month beginning July 1, 2026.
The FDA reviewed the Foundayo application in just 50 days under a Commissioner’s National Priority Voucher pilot program, making it the fastest approval of a new molecular entity since 2002. That regulatory speed is its own headline.
What This Means for the Broader Market
The oral GLP-1 approval isn’t just a Lilly story — it’s a market structure story. Injectable GLP-1s built a massive but friction-filled market: cold storage requirements, weekly injection routines, and access barriers kept a significant portion of eligible patients on the sidelines. Fewer than 1 in 10 people who could benefit from a GLP-1 are currently taking one. A pill changes that calculus dramatically, and a larger addressable patient pool creates downstream opportunities across the healthcare ecosystem.
For smaller companies building in adjacent spaces — weight management technology platforms, metabolic disease diagnostics, complementary therapeutics — this approval accelerates the market they’re betting on. Novo Nordisk’s early data already suggests the pill is expanding the obesity treatment market rather than simply cannibalizing injectable demand, with more than 600,000 prescriptions for the Wegovy pill recorded in March alone.
The Competitive Pressure Is Real
Lilly’s approval also puts pressure on every company in the obesity space without an oral option. Novo has a head start on the pill market but carries the food and water restriction disadvantage. Other GLP-1 developers — many of them smaller biotechs — now face an even higher innovation bar. The era of “we have a GLP-1” being sufficient is over. Differentiation by mechanism, convenience, side effect profile, or patient population is now the only viable path to relevance.
Lilly expects Foundayo approval in more than 40 countries over the next year and has invested more than $55 billion in manufacturing since 2020 to support global scale — a moat that smaller competitors cannot easily replicate, making niche differentiation even more critical for emerging players.
The oral GLP-1 market is now officially open. The question for small and microcap investors is which companies are building the infrastructure, tools, and therapies that benefit from a world where obesity treatment becomes a daily pill.
Biogen (Nasdaq: BIIB) is making its most consequential portfolio move in years, announcing a definitive agreement to acquire Apellis Pharmaceuticals (Nasdaq: APLS) for $41.00 per share in cash — an upfront equity consideration of approximately $5.6 billion — plus a contingent value right (CVR) tied to future sales milestones for its flagship eye disease therapy. The deal closed out March with a statement: big pharma is hungry, and specialty biotech is on the menu.
The transaction carries an 86% premium to Apellis’ 90-day volume-weighted average stock price and a 35% premium to its 52-week high. It is expected to close in the second quarter of 2026.
What Biogen Is Getting
At the center of the deal are two commercialized complement-targeting therapies: SYFOVRE® (pegcetacoplan injection), approved for geographic atrophy (GA) secondary to age-related macular degeneration, and EMPAVELI® (pegcetacoplan), approved across three rare immune-mediated conditions — C3 glomerulopathy (C3G), primary IC-MPGN, and paroxysmal nocturnal hemoglobinuria (PNH).
Together, the two drugs generated $689 million in combined net product revenue in 2025, with growth expected in the mid-to-high teens annually through at least 2028. For a company navigating revenue headwinds from its legacy MS portfolio, that near-term visibility is exactly what Biogen needed.
SYFOVRE holds particular strategic weight as the first-ever approved therapy for geographic atrophy — a progressive retinal disease affecting more than five million people globally. Long-term efficacy data shows the drug can delay GA lesion progression by approximately 1.5 years in key patient populations, giving the asset durable commercial runway. The GA space is one that smaller innovators are also actively pursuing. Ocugen (Nasdaq: OCGN), is developing a gene therapy approach targeting inherited retinal diseases — the kind of differentiated, mechanism-driven science that has increasingly attracted large-cap attention.
The Nephrology Angle
Beyond the immediate revenue story, the strategic rationale runs deeper into kidney disease. Apellis brings an established nephrology sales infrastructure that Biogen intends to leverage for felzartamab, its Phase 3 kidney disease candidate with a first trial readout expected in the first half of 2027.
EMPAVELI’s rare kidney disease approvals — including the only FDA-approved treatment for pediatric patients with C3G and the first approval for post-transplant C3G recurrence — underscore how defensible rare nephrology positions can be. Two other emerging growth companies are staking ground in adjacent kidney disease spaces: Unicycive Therapeutics (Nasdaq: UNCY), developing oxylanthanum carbonate for hyperphosphatemia in chronic kidney disease patients, and Eledon Pharmaceuticals (Nasdaq: ELDN), advancing therapies focused on reducing kidney transplant rejection. The Biogen-Apellis deal reinforces that nephrology is becoming a high-value destination for large-cap dealmaking.
A Market Signal Worth Noting
The Apellis acquisition didn’t land in a vacuum. Earlier today, Eli Lilly announced a separate agreement to acquire Centessa Pharmaceuticals for up to $47.00 per share — a deal valued at approximately $7.8 billion including contingent payments — to bolster its neuroscience pipeline in sleep-wake disorders. Two major biotech acquisitions announced on the same day signals something broader: pharmaceutical companies with strong balance sheets are actively scanning for de-risked, commercially validated or late-stage assets, and they’re willing to pay premium prices to get them.
For investors tracking small and microcap biotech, that backdrop matters. Companies building real clinical differentiation in immunology, nephrology, and ophthalmology are operating in exactly the spaces that large pharma is now paying billions to enter.
CVR Structure and Financial Outlook
The CVR entitles Apellis shareholders to two potential payments of $2 per share, contingent on SYFOVRE hitting $1.5 billion and $2 billion in annual global net sales between 2027 and 2030. Biogen expects the deal to be increasingly accretive to non-GAAP diluted EPS starting in 2027, with full de-leveraging targeted by end of 2027.
Disciplined posture reflects consumer-first enrollment, an intentional Medicare Advantage pullback driven by market realities, continued special needs plans (“SNP”) leadership, targeted AI investment, and a focus on cash, back-book durability, and consolidation readiness
CHICAGO, March 31, 2026 (GLOBE NEWSWIRE) — GoHealth, Inc. (NASDAQ: GOCO) (“GoHealth” or the “Company”), a leading health insurance marketplace and Medicare-focused digital health company, today announced financial results for the three and twelve months ended December 31, 2025.
GoHealth’s Chief Executive Officer, Vijay Kotte commented, “The Medicare Advantage market remains in a structural reset going into 2026, and our view is that health plans continue to prioritize retention, member quality, and disciplined unit economics. We anticipated many of these dynamics earlier in the cycle, and our pullback in 2025 was intentional. In this environment, consumers need a trusted partner more than ever. Our focus is helping ensure members enroll in plans that truly fit their needs, even when that means confirming their current coverage remains the best option. At the same time, we are maintaining disciplined focus on cash and improving our capital structure, while continuing tactical investments in technology and AI that improve efficiency today, support lower acquisition costs now and in the future, and position us to ramp quickly as conditions improve.”
GoHealth navigated a materially different Medicare Advantage environment by intentionally pulling back Medicare Advantage activity, while aiming to preserve a consumer-first approach, protect liquidity, and invest in core capabilities, which should enable GoHealth to scale when market conditions stabilize. Based on its analysis, GoHealth believes health plans will continue to emphasize margin integrity, renewal stability, and long-term member value over raw enrollment growth.
GoHealth anticipated this shift and aligned its operating model, accordingly, focusing on:
Retention and High-Quality Member Book: Delivered materially improved year-over-year retention, reinforcing cohort quality and proprietary PlanFit logic while supporting the durability of GoHealth’s commission receivable asset and broader back book.
Intentional Pullback Grounded in Consumer Fit and Renewal Economics: Deliberately pulled back Medicare Advantage activity where first-renewal probability did not support attractive economics, prioritizing appropriate plan fit for consumers and long-term cohort quality.
Leadership with Special Needs Plans (“SNP”) populations: Continued leadership in key SNP categories due to our proprietary enrollment and servicing tools, technology and experience, as health plans pursued targeted growth while member stability, renewal duration, and outcomes remained especially important.
Technology and AI Investment: Continued targeted investment in built-for-purpose, proprietary agentic AI and automation to lower customer acquisition costs, improve year-one payback, reduce operational friction, and enable agents with more capacity to focus on top-of-license advisory work, while supporting a consumer-first approach by helping ensure members are matched with the plans that best meet their needs.
Strategic Flexibility: Optimized cash, protected the commissions receivable, and preserved operating flexibility.
Consolidation Readiness: Maintaining high conviction that the fragmented broker landscape will consolidate, positioning GoHealth to lead disciplined integration opportunities with the right partners at the right time.
“Our full-year performance reflects disciplined execution in a market where health plans are prioritizing margin stability and member quality”, said Brendan Shanahan, CFO of GoHealth. “Operating cash flow will remain the primary lens for our capital allocation decisions. As we move forward, we are concentrating investment where we have confidence in durable returns, strengthening retention, and continuing to improve efficiency through practical automation and AI.”
About GoHealth, Inc. GoHealth is a leading health insurance marketplace and Medicare-focused digital health company whose purpose is to compassionately ensure consumers’ peace of mind when making healthcare decisions so they can focus on living life. For many of these consumers, enrolling in a health insurance plan is confusing and difficult, and seemingly small differences between health plans may lead to significant out-of-pocket costs or lack of access to critical providers and medicines. GoHealth’s proprietary technology platform leverages modern machine-learning algorithms, powered by over two decades of insurance purchasing behavior, to reimagine the process of matching a health plan to a consumer’s specific needs. Its unbiased, technology-driven marketplace coupled with highly skilled licensed agents has facilitated the enrollment of millions of consumers in Medicare plans since GoHealth’s inception. For more information, visit https://www.gohealth.com.
Eli Lilly (NYSE: LLY) is making one of its boldest neuroscience moves yet, announcing a definitive agreement to acquire clinical-stage biotech Centessa Pharmaceuticals (Nasdaq: CNTA) in a deal valued at up to $47.00 per share — representing a total potential equity value approaching $7.8 billion when contingent payments are included.
The upfront cash consideration of $38.00 per share reflects an aggregate equity value of approximately $6.3 billion and carries a 40.5% premium to Centessa’s 30-day volume-weighted average trading price ended March 30, 2026. Shareholders will also receive one non-transferable contingent value right (CVR) worth up to an additional $9.00 per share, tied to three FDA approval milestones for Centessa’s lead drug candidates.
What Lilly Is Really Buying
The deal is fundamentally about orexin receptor 2 (OX2R) science — a mechanism that sits at the neurobiological center of how the brain regulates the sleep-wake cycle. Centessa has spent years building what it believes is a potential best-in-class pipeline of OX2R agonists, with its lead candidate cleminorexton (formerly ORX750) having already shown promising Phase 2a clinical data across three major sleep disorders: narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia.
Beyond cleminorexton, Centessa’s portfolio includes additional clinical and preclinical-stage assets targeting neurological, neurodegenerative, and neuropsychiatric indications — giving Lilly a broader platform than a single drug acquisition would suggest.
The CVR Structure
The contingent value rights break down as follows: $2.00 per CVR upon FDA approval of cleminorexton or ORX142 for narcolepsy type 2 before the fifth anniversary of close; $5.00 per CVR upon FDA approval for idiopathic hypersomnia within the same window; and $2.00 per CVR upon the first FDA approval of either candidate for any indication before January 1, 2030.
CVR structures are increasingly common in biopharma M&A as a tool to bridge valuation gaps between buyers and sellers when clinical outcomes remain uncertain. For Centessa shareholders, the arrangement means meaningful upside if the pipeline delivers — but no guarantees.
Strategic Fit and Timing
The acquisition lands at a moment when sleep disorder therapeutics are gaining serious commercial momentum. The emergence of orexin-based therapies — like Idorsia’s daridorexant and Eisai and Biogen’s lemborexant — has validated the mechanism on the wake-promotion side of the equation. Centessa’s OX2R agonist approach works in the opposite direction, promoting wakefulness rather than suppressing it, which addresses a different and underserved patient population.
For Lilly, a company already navigating massive commercial demands from its GLP-1 and Alzheimer’s franchises, adding a differentiated neuroscience platform signals a commitment to diversifying its long-range pipeline.
The transaction is structured as a scheme of arrangement under English and Welsh law and is expected to close in the third quarter of 2026, pending Centessa shareholder approval, High Court sanction, and customary regulatory clearances. Approximately 24.1% of Centessa’s outstanding shares are already locked up through voting and support agreements signed by major investors including Medicxi Ventures, Index Ventures, and General Atlantic.
Robert LeBoyer, Senior Vice President, Equity Research Analyst, Biotechnology, Noble Capital Markets, Inc.
Refer to the full report for the price target, fundamental analysis, and rating.
NDA Sumisssion Was Accepted In January. Unicycive reported loss for FYQ25 of $26.6 million or $(1.67) per share. Importantly, the resubmission of the NDA for oxylanthanum calcium (OLC), its phosphate binder for controlling high phosphate levels in renal dialysis patients, was accepted for filing by the FDA. The PDUFA data is June 19, 2026. Cash on December 31, 2026 was $54.9 million, which we estimate is sufficient to last through product launch and the first quarter of OLC sales.
We Believe Previous Issues Have Been Settled. The NDA was submitted in December 2025 and accepted for filing in January. FDA acceptance and notification of the PDUFA date signifies that the application is complete for review. There were no questions about the third-party manufacturing issue that stopped the review process in June 2025. We believe the corrective actions have addressed the problem, allowing for marketing approval by June 2026.
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*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision.
Robert LeBoyer, Senior Vice President, Equity Research Analyst, Biotechnology, Noble Capital Markets, Inc.
Refer to the full report for the price target, fundamental analysis, and rating.
Mpox Vaccine Clinical Supplies Expected To Be Ready Soon. GeoVax announced the completion of clinical supply testing of GEO-MVA, its modified vaccinia ankara (MVA) vaccine for Mpox/smallpox. The release of vaccine that can be used in clinical trials is expected in early April. This is an important milestone in preparation for the Phase 3 trial planned for late FY2026.
Preparation for Phase 3 Bridging Study and Commercialization. GeoVax is preparing for an immune bridging study to show GEO-MVA stimulates an immune response that is non-inferior to a commercial Mpox vaccine. The study was designed to meet requirements for the European Medicines Agency’s expedited development pathway for Marketing Authorization.
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*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision.
Robert LeBoyer, Senior Vice President, Equity Research Analyst, Biotechnology, Noble Capital Markets, Inc.
Refer to the full report for the price target, fundamental analysis, and rating.
Cardiff Oncology Held A KOL Discussion. On March 25, Cardiff Oncology held a webcast with two world-renown oncologists with experience in drug development and patient treatment. The discussion began with a review of the Phase 2 data by Dr. Mani Mohindru, the Interim CEO. The discussion centered on aspects of the trial, including the outcome data, practical use, and competitive therapies.
The Discussion Included Significance Of Phase 2 Outcomes. The presentation began with a review of Phase 2 data announced in January 2026, with comments by the KOLs. They pointed to the response rate (RR) of 72.2% and the median progression-free survival (PFS) that has not yet been reached. Importantly, onvansertib did not cause additional toxicities to the combination chemotherapy regimen.
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*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision.
OVERLAND PARK, Kan.–(BUSINESS WIRE)– SelectQuote, Inc. (NYSE: SLQT) (the “Company”) announced today that the Company received a notice (the “Notice”) from the New York Stock Exchange (the “NYSE”) indicating that the Company is no longer in compliance with Section 802.01C of the NYSE Listed Company Manual because the average closing price of the Company’s common stock was less than $1.00 per share over a consecutive 30 trading-day period.
The Company recently reported strong fiscal second quarter 2026 results on February 5th. Earlier this year, the Company executed a new $415 million credit facility which extends the majority of its debt maturities to 2031. SelectQuote’s strong liquidity position and robust operating cash flow outlook provide the Company operational flexibility to execute its strategy and achieve its goals. The Company projects fiscal 2026 operating cash flow in the range of $25 million to $35 million and expects the business will continue to generate meaningful cash flow growth in years to come.
The Company has notified the NYSE of its intent to cure the stock price deficiency and return to compliance with the continued listing standard. The Company can regain compliance at any time within the six-month cure period following receipt of the Notice if, on the last trading day of any calendar month during the cure period, the Company’s common stock has a closing share price of at least $1.00 and an average closing share price of at least $1.00 over the 30 trading-day period ending on the last trading day of that month.
The Company intends to closely monitor its stock price during the cure period for non-compliance. The Company plans to take appropriate actions if necessary to maintain its listing on the NYSE. SelectQuote’s common stock will continue to be listed and traded on the NYSE during the applicable cure period, subject to the Company’s compliance with other NYSE continued listing standards.
Forward Looking Statements
This release contains forward-looking statements. These forward-looking statements reflect our current views with respect to, among other things, future events and our financial performance. These statements are often, but not always, made through the use of words or phrases such as “may,” “should,” “could,” “predict,” “potential,” “believe,” “will likely result,” “expect,” “continue,” “will,” “anticipate,” “seek,” “estimate,” “intend,” “plan,” “projection,” “would” and “outlook,” or the negative version of those words or other comparable words or phrases of a future or forward-looking nature. These forward-looking statements are not historical facts, and are based on current expectations, estimates and projections about our industry, management’s beliefs, and certain assumptions made by management, many of which, by their nature, are inherently uncertain and beyond our control, including our ability to regain compliance with the continued listing standards of the NYSE within the applicable cure period and our ability to continue to comply with applicable NYSE listing standards. Accordingly, we caution you that any such forward-looking statements are not guarantees of future performance and are subject to risks, assumptions and uncertainties that are difficult to predict. Although we believe that the expectations reflected in these forward-looking statements are reasonable as of the date made, actual results may prove to be materially different from the results expressed or implied by the forward-looking statements. There are or will be important factors that could cause our actual results to differ materially from those indicated in these forward-looking statements, including, but not limited to, the following: our reliance on a limited number of insurance carrier partners and any potential termination of those relationships or failure to develop new relationships; existing and future laws and regulations affecting the health insurance market; changes in health insurance products offered by our insurance carrier partners and the health insurance market generally; insurance carriers offering products and services directly to consumers; changes to commissions paid by insurance carriers and underwriting practices; competition with brokers, exclusively online brokers and carriers who opt to sell policies directly to consumers; competition from government-run health insurance exchanges; developments in the U.S. health insurance system; our dependence on revenue from carriers in our senior segment and downturns in the senior health as well as life, automotive and home insurance industries; our ability to develop new offerings and penetrate new vertical markets; risks from third-party products; failure to enroll individuals during the Medicare annual enrollment period; our ability to attract, integrate and retain qualified personnel; our dependence on lead providers and ability to compete for leads; failure to obtain and/or convert sales leads to actual sales of insurance policies; access to data from consumers and insurance carriers; accuracy of information provided from and to consumers during the insurance shopping process; cost-effective advertisement through internet search engines; ability to contact consumers and market products by telephone; global economic conditions, including inflation; disruption to operations as a result of future acquisitions; significant estimates and assumptions in the preparation of our financial statements; impairment of goodwill; potential litigation and other legal proceedings or inquiries; our existing and future indebtedness; our ability to maintain compliance with our debt covenants; access to additional capital; failure to protect our intellectual property and our brand; fluctuations in our financial results caused by seasonality; accuracy and timeliness of commissions reports from insurance carriers; timing of insurance carriers’ approval and payment practices; factors that impact our estimate of the constrained lifetime value of commissions per policyholder; changes in accounting rules, tax legislation and other legislation; disruptions or failures of our technological infrastructure and platform; failure to maintain relationships with third-party service providers; cybersecurity breaches or other attacks involving our systems or those of our insurance carrier partners or third-party service providers; our ability to protect consumer information and other data; failure to market and sell Medicare plans effectively or in compliance with laws; and other factors related to our pharmacy business, including manufacturing or supply chain disruptions, access to and demand for prescription drugs, changes in reimbursement rates under our contracts with pharmacy benefit managers, and regulatory changes or other industry developments that may affect our pharmacy operations. For a further discussion of these and other risk factors that could impact our future results and performance, see the section entitled “Risk Factors” in the most recent Annual Report on Form 10-K (the “Annual Report”) and subsequent periodic reports filed by us with the Securities and Exchange Commission. Accordingly, you should not place undue reliance on any such forward-looking statements. Any forward-looking statement speaks only as of the date on which it is made, and, except as otherwise required by law, we do not undertake any obligation to publicly update or review any forward-looking statement, whether as a result of new information, future developments or otherwise.
About SelectQuote
Founded in 1985, SelectQuote (NYSE: SLQT) pioneered the model of providing unbiased comparisons from multiple, highly-rated insurance companies, allowing consumers to choose the policy and terms that best meet their unique needs. Two foundational pillars underpin SelectQuote’s success: a strong force of highly-trained and skilled agents who provide a consultative needs analysis for every consumer, and proprietary technology that sources and routes high-quality leads. Today, the Company operates an ecosystem offering high touchpoints for consumers across insurance, pharmacy, and virtual care.
With an ecosystem offering engagement points for consumers across insurance, Medicare, pharmacy, and value-based care, the company now has three core business lines: SelectQuote Senior, SelectQuote Healthcare Services, and SelectQuote Life. SelectQuote Senior serves the needs of a demographic that sees around 10,000 people turn 65 each day with a range of Medicare Advantage and Medicare Supplement plans. SelectQuote Healthcare Services is comprised of the SelectRx Pharmacy, a Patient-Centered Pharmacy Home™ (PCPH) accredited pharmacy, SelectPatient Management, a provider of chronic care management services, and Healthcare Select, which proactively connects consumers with a wide breadth of healthcare services supporting their needs.
Merck (NYSE: MRK) announced Tuesday it has entered into a definitive agreement to acquire Terns Pharmaceuticals (Nasdaq: TERN), a clinical-stage oncology company, for $53.00 per share in cash — representing an approximate equity value of $6.7 billion, or roughly $5.7 billion net of acquired cash. The deal carries a 31% premium to Terns’ 60-day volume-weighted average price and a 42% premium to its 90-day VWAP as of March 24, 2026.
The acquisition is a textbook small-cap-to-acquisition story. Less than 18 months ago, Terns was trading below $2 per share with a market cap well under $200 million. By the end of 2025, the stock had surged more than 770% year-to-date on the back of compelling Phase 1 clinical data. As of Tuesday’s announcement, shareholders who held through the volatility are looking at a $53 payday — a return that underscores exactly why early-stage biotech remains one of the most asymmetric bets in the small and microcap universe.
At the center of this deal is TERN-701, an investigational oral allosteric BCR::ABL1 tyrosine kinase inhibitor (TKI) currently being evaluated in the Phase 1/2 CARDINAL trial for patients with Philadelphia chromosome-positive (Ph+) chronic phase chronic myeloid leukemia (CML). Specifically, the drug targets patients who have already received at least one prior TKI and experienced treatment failure, suboptimal response, or intolerance.
What separates TERN-701 from existing CML therapies is its mechanism and early efficacy signal. The drug is designed to bind to the ABL myristoyl pocket — a distinct binding site from most approved TKIs — giving it the potential to work in patients who have already failed other therapies, including those with difficult resistance mutations like T315I. In clinical data presented through the CARDINAL trial, 64% of efficacy-evaluable patients achieved major molecular response by 24 weeks, with 75% achieving MMR among those treated at doses above 320mg. The safety profile has also been notably clean, with low rates of severe adverse events, minimal blood pressure changes, and low lipase elevation — a meaningful differentiator given the side-effect profiles associated with several competing agents.
The FDA recognized the drug’s potential in March 2024, granting TERN-701 Orphan Drug Designation for the treatment of CML. Merck is now betting that designation translates into a commercially viable, potentially best-in-class therapy within its growing hematology portfolio — which already includes three Phase 3 candidates across leukemias, lymphomas, and myeloproliferative neoplasms.
Merck expects to account for the transaction as an asset acquisition, with the deal expected to close in the second quarter of 2026, pending a successful tender offer and Hart-Scott-Rodino antitrust clearance. The charge will be approximately $5.8 billion, or roughly $2.35 per share, reflected in both Q2 and full-year 2026 results.
For the small and microcap investor community, this deal is more than just a pharma headline. It’s a reminder that the path from sub-$2 clinical-stage company to a multi-billion-dollar buyout target is very much alive — and that the CARDINAL data milestones many overlooked in 2024 were the signals that mattered most.
