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Release – Helius Medical Technologies Inc. Appoints Antonella Favit-Van Pelt M.D. Ph.D. as Chief Medical Officer

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Helius Medical Technologies, Inc. Appoints Antonella Favit-Van Pelt, M.D., Ph.D. as Chief Medical Officer

 

NEWTOWN, Pa., July 08, 2021 (GLOBE NEWSWIRE) — Helius Medical Technologies, Inc. (Nasdaq:HSDT) (TSX:HSM) (“Helius” or the “Company”), a neurotech company focused on neurological wellness, today announced the appointment of Antonella Favit-Van Pelt, M.D., Ph.D. to the position of Chief Medical Officer.

“I am very pleased to welcome Dr. Favit-Van Pelt to Helius, who joins our team with a clinical and academic background in Neurology, as well as 20 years of experience advising and leading medical programs for healthcare companies – including both large, globally-diversified corporations and smaller, earlier-stage companies,” said Helius CEO, Dane Andreeff. “I look forward to her future contributions as we continue our efforts to raise awareness of PoNS technology and its therapeutic benefits among clinicians, patients and payors in the U.S. market, while planning to enter the next phase of our clinical and regulatory strategy.”

“Helius is breaking new ground in the field of neurology with its PoNS technology, which has great potential as a non-invasive, non-drug therapy for patients suffering from a variety of chronic and debilitating neurological conditions,” said Dr. Favit-Van Pelt. “I am excited to join Helius on the heels of its first U.S. regulatory clearance in multiple sclerosis and look forward to continuing the Company’s recent market development, clinical and regulatory progress.”

Prior to joining Helius, Dr. Favit-Van Pelt led U.S. Medical Strategy for the Neurology program of H. Lundbeck A/S (LUN.CO, LUN DC, HLUYY), a global pharmaceutical company that specializes in the treatment of brain diseases, from 2018 to 2021. In this position, she oversaw the U.S. medical and life-cycle program activities related to therapies for movement disorders and epilepsy.

In 2013, Dr. Favit-Van Pelt founded Synaerion Therapeutics (“Synaerion”) and, in 2016, its affiliate Thera Neuropharma, Inc. (“Thera”), two privately-held biotechnology companies developing a small molecule regenerative therapy and RNAi-based integrated technology platform for ALS and traumatic brain injury (“TBI”). She oversaw all aspects of Synaerion’s and Thera’s management and strategy as Chief Executive Officer, President & Chairwoman of the Board from 2014 to 2017 and she continues to serve as President & Chairwoman. In 2009, she founded StratMedica, LLC, a privately-held company designed to provide corporate clients with contract senior management support. As Principal of StratMedica from 2009 to 2016, she directed clinical development and medical programs for eight healthcare companies, including Johnson & Johnson (NYSE: JNJ) and Teva (NYSE: TEVA). Dr. Favit-Van Pelt served as Senior Director and Global Medical Lead at Shire Pharmaceuticals (Nasdaq: SPHG) from 2007 to 2008, as Director of Medical Strategy at Bristol-Myers Squibb (NYSE: BMY) from 2005 to 2007, and as Global Clinical Development Lead at GE Healthcare (formerly Amersham Health) from 2001 to 2005.

Dr. Favit-Van Pelt is a Board-certified neurologist who began clinical practice activity in 1994, with a focus on patients with rare neuromuscular disorders. She holds a graduate degree in Medicine and Surgery and a Ph.D. in Pharmacology from the School of Medicine and Surgery at the University of Catania, Italy.        

As a material inducement to entering into employment with Helius, Dr. Favit-Van Pelt, who was not previously an employee or director of Helius, received options to purchase 18,000 shares of the Company’s Class A common stock under Helius’ Inducement Plan. The equity award under Helius’ Inducement Plan was approved by the Company’s independent directors in accordance with Nasdaq Listing Rule 5635(c)(4), which also requires a public announcement of equity awards that are not made under a stockholder approved equity plan.

The options awards have an exercise price of $16.45 per share, the closing price of Helius’ Class A common stock on July 7, 2021, the date of the grant. The options have a ten-year term and vest over a period of four years, with 25% vesting per year on the anniversary date of grant, provided Dr. Favit-Van Pelt’s employment is continuing on each such date, and subject to acceleration or forfeiture upon the occurrence of certain events as set forth in Dr. Favit-Van Pelt’s option agreement.

About Helius Medical Technologies, Inc.

Helius Medical Technologies is a neurotech company focused on neurological wellness. The Company’s purpose is to develop, license and acquire unique and non-invasive platform technologies that amplify the brain’s ability to heal itself. The Company’s first commercial product is the Portable Neuromodulation Stimulator (PoNS™). For more information, visit www.heliusmedical.com.

About the PoNS™ Device and PoNS Treatment™

The Portable Neuromodulation Stimulator (PoNS™) is an innovative non-surgical device, inclusive of a controller and mouthpiece, which delivers electrical stimulation to the surface of the tongue to provide treatment of gait deficit. The PoNS device is indicated for use in the United States as a short term treatment of gait deficit due to mild-to-moderate symptoms from multiple sclerosis (“MS”) and is to be used as an adjunct to a supervised therapeutic exercise program in patients 22 years of age and over by prescription only. It is authorized for sale in Canada as a class II, non-implantable, medical device intended as a short term treatment (14 weeks) of gait deficit due to mild and moderate symptoms from MS, and chronic balance deficit due to mild-to-moderate traumatic brain injury (“mmTBI”) and is to be used in conjunction with physical therapy. PoNS is an investigational medical device in the European Union (“EU”) and Australia (“AUS”). It is currently under premarket review by the AUS Therapeutic Goods Administration.

Cautionary Disclaimer Statement: 

Certain statements in this news release are not based on historical facts and constitute forward-looking statements or forward-looking information within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and Canadian securities laws. All statements other than statements of historical fact included in this news release are forward-looking statements that involve risks and uncertainties. Forward-looking statements are often identified by terms such as “believe,” “continue,” “looking ahead,” “will,” “committed to,” “goal,” “expect,” “remain,” “hope” and similar expressions. Such forward-looking statements include, among others, statements regarding the Company’s future strategic and operational execution, the next phase of the Company’s market development activities, the Company’s ability to spread awareness of of PoNS technology, clinical and regulatory development plans for the PoNS device, and the timing and success of the Company’s commercialization efforts in the United States.

These statements involve substantial known and unknown risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those expressed or implied by such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include uncertainties regarding the Company’s capital requirements to achieve its business objectives, the impact of the COVID-19 pandemic, the Company’s ability to train physical therapists in the supervision of the use of the PoNS Treatment, the Company’s ability to secure contracts with rehabilitation clinics, the Company’s ability to obtain national Medicare coverage and to obtain a reimbursement code so that the PoNS device is covered by Medicare and Medicaid, the Company’s ability to build internal commercial infrastructure, market awareness of the PoNS device, future clinical trials and the clinical development process, manufacturing and supply chain risks, potential changes to the MCIT program, the product development process and FDA regulatory submission review and approval process, other development activities, ongoing government regulation, and other risks detailed from time to time in the “Risk Factors” sections of the Company’s Annual Report on Form 10-K for the year ended December 31, 2020, its Quarterly Report on Form 10-Q for the quarter ended March 31, 2021 and its other filings with the United States Securities and Exchange Commission and the Canadian securities regulators, which can be obtained from either at www.sec.gov or www.sedar.com.The reader is cautioned not to place undue reliance on any forward-looking statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company assumes no obligation to update any forward-looking statement or to update the reasons why actual results could differ from such statements except to the extent required by law.

The Toronto Stock Exchange has not reviewed and does not accept responsibility for the adequacy or accuracy of the content of this news release. 

CONTACT: Investor Relations Contact: Westwicke on behalf of Helius Medical Technologies, Inc. Jack Powell, Vice President [email protected]

Release – Helius Medical Technologies, Inc. to Participate in the Annual World Congress of the Society for Brain Mapping and Therapeutics

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Helius Medical Technologies, Inc. to Participate in the Annual World Congress of the Society for Brain Mapping and Therapeutics

 

NEWTOWN, Pa., July 07, 2021 (GLOBE NEWSWIRE) — Helius Medical Technologies, Inc. (Nasdaq:HSDT) (TSX:HSM) (“Helius” or the “Company”), a neurotech company focused on neurological wellness, today announced it will participate in the Annual World Congress of the Society for Brain Mapping and Therapeutics, which will be held from July 8-11th in Los Angeles, California.

The Company has been selected to receive the Pioneer in Technology Award during the event, an award presented by the Society to trail blazing companies who have facilitated the development of pioneering technologies through interdisciplinary approaches that have impacted diagnostics, treatment and healthcare delivery in unprecedented ways.

Dr. Jonathan Sackier, Helius’ Co-Founder and Medical Advisor, will host a presentation during the event titled: From porpoise to PoNS™: the bridge of Varolio and translingual neuromodulation to address balance and gait symptoms. The presentation will include a discussion of the history of neuromodulation, the science behind Helius’ PoNS technology, data from trials in experimental and clinical settings – including trials focused on multiple sclerosis, traumatic brain injury, stroke and cerebral palsy – and the PoNS device’s recent regulatory clearances. The presentation will be held on July 11th at 10 a.m. Pacific Time.

About Helius Medical Technologies, Inc.

Helius Medical Technologies is a neurotech company focused on neurological wellness. The Company’s purpose is to develop, license and acquire unique and non-invasive platform technologies that amplify the brain’s ability to heal itself. The Company’s first commercial product is the Portable Neuromodulation Stimulator (PoNSTM). For more information, visit www.heliusmedical.com.

About the PoNS™ Device and PoNS Treatment™

The Portable Neuromodulation Stimulator (PoNSTM) is an innovative non-surgical device, inclusive of a controller and mouthpiece, which delivers electrical stimulation to the surface of the tongue to provide treatment of gait deficit. The PoNS device is indicated for use in the United States as a short term treatment of gait deficit due to mild-to-moderate symptoms from multiple sclerosis (“MS”) and is to be used as an adjunct to a supervised therapeutic exercise program in patients 22 years of age and over by prescription only. It is authorized for sale in Canada as a class II, non-implantable, medical device intended as a short term treatment (14 weeks) of gait deficit due to mild and moderate symptoms from MS, and chronic balance deficit due to mild-to-moderate traumatic brain injury (“mmTBI”) and is to be used in conjunction with physical therapy. PoNS is an investigational medical device in the European Union (“EU”) and Australia (“AUS”). It is currently under premarket review by the AUS Therapeutic Goods Administration.

Cautionary Disclaimer Statement: 

Certain statements in this news release are not based on historical facts and constitute forward-looking statements or forward-looking information within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and Canadian securities laws. All statements other than statements of historical fact included in this news release are forward-looking statements that involve risks and uncertainties. Forward-looking statements are often identified by terms such as “believe,” “continue,” “looking ahead,” “will,” “committed to,” “goal,” “expect,” “remain,” “hope” and similar expressions. Such forward-looking statements include, among others, statements regarding the Company’s future strategic and operational execution, the next phase of the Company’s market development activities, clinical and regulatory development plans for the PoNS device, and the timing and success of the Company’s commercialization efforts in the United States.

These statements involve substantial known and unknown risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those expressed or implied by such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include uncertainties regarding the Company’s capital requirements to achieve its business objectives, the impact of the COVID-19 pandemic, the Company’s ability to train physical therapists in the supervision of the use of the PoNS Treatment, the Company’s ability to secure contracts with rehabilitation clinics, the Company’s ability to obtain national Medicare coverage and to obtain a reimbursement code so that the PoNS device is covered by Medicare and Medicaid, the Company’s ability to build internal commercial infrastructure, market awareness of the PoNS device, future clinical trials and the clinical development process, manufacturing and supply chain risks, potential changes to the MCIT program, the product development process and FDA regulatory submission review and approval process, other development activities, ongoing government regulation, and other risks detailed from time to time in the “Risk Factors” sections of the Company’s Annual Report on Form 10-K for the year ended December 31, 2020, its Quarterly Report on Form 10-Q for the quarter ended March 31, 2021 and its other filings with the United States Securities and Exchange Commission and the Canadian securities regulators, which can be obtained from either at www.sec.gov or www.sedar.com.The reader is cautioned not to place undue reliance on any forward-looking statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company assumes no obligation to update any forward-looking statement or to update the reasons why actual results could differ from such statements except to the extent required by law.

The Toronto Stock Exchange has not reviewed and does not accept responsibility for the adequacy or accuracy of the content of this news release.

CONTACT: Investor Relations Contact: Westwicke on behalf of Helius Medical Technologies, Inc. Jack Powell, Vice President [email protected]

Release – Capstone Green Energy Signs 10-Year Service Contract On Energy Efficiency System At A Large Spirit Distillery In Jamaica

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Capstone Green Energy Signs 10-Year Service Contract On Energy Efficiency System At A Large Spirit Distillery In Jamaica

 

VAN NUYS, CA / ACCESSWIRE / July 8, 2021 / Capstone Green Energy Corporation (www.CapstoneGreenEnergy.com) (NASDAQ:CGRN), formerly Capstone Turbine Corporation (www.capstoneturbine.com) (NASDAQ:CPST) (“Capstone” or the “Company”), announced today that Innovative Energy Company Limited, Capstone’s exclusive distributor for Jamaica and distributor for the oil and gas markets in Guyana, signed a new 10-year Capstone Factory Protection Plan (FPP) service contract for a Capstone Signature Series C200S system installed in Jamaica.

The Capstone Signature Series C200S system is owned and operated by one of the island’s largest and oldest spirit distilleries. The C200S, commissioned in late 2020, is used for 24×7 electrical and thermal energy generation and is configured for dual-mode operation allowing the distillery to provide backup power to critical loads in the event of a grid outage.

The project design efficiency is 85% and produces 100% of the distillery’s annual electrical energy, reducing the distillery’s total energy costs by 26%. Capstone’s Integrated Heat Recovery Module (iHRM) is mounted on the roof of the C200S and produces 1,000 MBtu/hr of hot water or 100% of the boiler feed water requirements, utilizing the microturbine’s exhaust heat. The system is configured as a low-pressure natural gas unit with onboard fuel compressors to provide the required fuel pressure to the engine. The project is also estimated to reduce the site’s greenhouse gas emissions by 14%.

The Capstone FPP will provide the end-use customer with fixed scheduled and unscheduled parts costs for the next 10 years, providing protection from future cost increases associated with the replacement of spare parts, commodity pricing, and import tariffs. “With the Capstone gold standard, all-inclusive Factory Protection Plan, our client is able to enjoy a 10-year, worry-free operational period, knowing that all maintenance costs for the project are covered,” said Nigel Davy, Managing Director of Innovative Energy Company Limited.

“We are pleased that Capstone Green Energy is playing a larger role in Jamaica’s commitment to integrate clean energy sources and increase energy resiliency as part of the Energy Cooperation Framework signed by the U.S. and Jamaica in 2018,” said Tracy Chidbachian, Capstone’s Director of Customer Service. “Capstone Green Energy, along with Innovative Energy Company, is leading the way in advancing Jamaica’s environmental goals by integrating clean energy sources, including natural gas and renewable energy,” concluded Ms. Chidbachian.

“With the change in climate and increase of tropical storms in the Caribbean, power outages are more than an inconvenience; they are a significant hazard. Power outages are detrimental to people’s well-being and safety and have a devastating impact on the region,” said Darren Jamison, President and Chief Executive Officer of Capstone Green Energy. “This new contract demonstrates that Innovative Energy Company is taking steps to keep up with the energy revolution and protect its end-use customers from prolonged unplanned power outages caused by severe weather,” concluded Mr. Jamison.

About Capstone Green Energy
Capstone Green Energy (www.CapstoneGreenEnergy.com) (NASDAQ:CGRN) is a leading provider of customized microgrid solutions and on-site energy technology systems focused on helping customers around the globe meet their environmental, energy savings, and resiliency goals. Capstone Green Energy focuses on four key business lines. Through its Energy as a Service (EaaS) business, it offers rental solutions utilizing its microturbine energy systems and battery storage systems, comprehensive Factory Protection Plan (FPP) service contracts that guarantee life-cycle costs, as well as aftermarket parts. Energy Conversion Products are driven by the Company’s industry-leading, highly efficient, low-emission, resilient microturbine energy systems offering scalable solutions in addition to a broad range of customer-tailored solutions, including hybrid energy systems and larger frame industrial turbines. The Energy Storage Products business line designs and installs microgrid storage systems creating customized solutions using a combination of battery technologies and monitoring software. Through Hydrogen Energy Solutions, Capstone Green Energy offers customers a variety of hydrogen products, including the Company’s microturbine energy systems.

For customers with limited capital or short-term needs, Capstone offers rental systems; for more information, contact: [email protected]. To date, Capstone has shipped over 10,000 units to 83 countries and estimates that, in FY21, it saved customers over $217 million in annual energy costs and approximately 397,000 tons of carbon. Total savings over the last three years are estimated at 1,115,100 tons of carbon and $698 million in annual energy savings.

For more information about the Company, please visit: www.CapstoneGreenEnergy.com. Follow Capstone Green Energy on Twitter, LinkedIn, Instagram, Facebook, and YouTube.

Cautionary Note Regarding Forward-Looking Statements
This release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, including statements regarding expectations for green initiatives and execution on the Company’s growth strategy and other statements regarding the Company’s expectations, beliefs, plans, intentions, and strategies. The Company has tried to identify these forward-looking statements by using words such as “expect,” “anticipate,” “believe,” “could,” “should,” “estimate,” “intend,” “may,” “will,” “plan,” “goal” and similar terms and phrases, but such words, terms and phrases are not the exclusive means of identifying such statements. Actual results, performance and achievements could differ materially from those expressed in, or implied by, these forward-looking statements due to a variety of risks, uncertainties and other factors, including, but not limited to, the following: the ongoing effects of the COVID-19 pandemic; the availability of credit and compliance with the agreements governing the Company’s indebtedness; the Company’s ability to develop new products and enhance existing products; product quality issues, including the adequacy of reserves therefor and warranty cost exposure; intense competition; financial performance of the oil and natural gas industry and other general business, industry and economic conditions; the Company’s ability to adequately protect its intellectual property rights; and the impact of pending or threatened litigation. For a detailed discussion of factors that could affect the Company’s future operating results, please see the Company’s filings with the Securities and Exchange Commission, including the disclosures under “Risk Factors” in those filings. Except as expressly required by the federal securities laws, the Company undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, changed circumstances or future events or for any other reason.

CONTACT:
Capstone Green Energy
Investor and investment media inquiries:
818-407-3628
[email protected]

SOURCE: Capstone Green Energy Corporation

Release – Endeavour Silver Produces 1073724 Oz Silver And 11166 Oz Gold For 2.0 Million Oz Silver Equivalents In Q2 2021

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Endeavour Silver Produces 1,073,724 Oz Silver And 11,166 Oz Gold For 2.0 Million Oz Silver Equivalents In Q2, 2021

 

VANCOUVER, British Columbia, July 08, 2021 (GLOBE NEWSWIRE) — Endeavour Silver Corp. (TSX: EDR, NYSE: EXK) reports production of 1,073,724 silver ounces (oz) and 11,166 gold oz in Q2, 2021, for silver equivalent (“AgEq”) production of 2.0 million oz at an 80:1 silver:gold ratio. Production continues to outpace the 2021 production guidance of 6.1-7.1 million silver equivalent ounces, totaling 3.9 million AgEq oz for the 6 months ended June 30, 2021.

Quarterly production increased significantly compared to Q2, 2020, when mining operations were temporarily suspended as mandated by the Mexican government to halt the spread of the COVID-19 pandemic from April 2020 to late May 2020.

2021 Second Quarter Highlights

  • Consolidated Production Ahead of Plan: Silver equivalent production at each mine is on track to meet or exceed 2021 production plans.

  • Guanacevi Production Ahead of Plan: Higher throughput and higher grades resulted in production exceeding plan during the quarter and ahead of the annual plan.

  • Bolanitos Production on Plan: Processed tonnes were ahead of plan, offset by slightly lower ore grades than planned during the quarter.

  • El Compas Production on Plan: Processed tonnes were ahead of plan, offset by slightly lower ore grades than planned during the quarter.

  • Metal Sales and Inventories: Sold 1,120,266 oz silver and 9,810 oz gold, held 459,659 oz silver and 1,891 oz gold of bullion inventory and 12,159 oz silver and 944 oz gold in concentrate inventory. Management withheld metal from sale during the price correction over last two weeks of June and plans to sell the withheld metal inventory in anticipation of a precious metal prices rebound in 2021.

  • Sold the El Cubo Assets: Completed the sale of the El Cubo mine in Guanajuato, Mexico to Guanajuato Silver (Formerly named VanGold Mining Corp) for $15 million in cash and share payments, with up to $3 million in contingent payments.

  • Seamless Management Succession Plan: Bradford Cooke stepped down as CEO and assumed the role of Executive Chair of the Company following the AGM on May 12, 2021. Dan Dickson assumed the role of CEO and Christine West was promoted to CFO.

  • Delivered Positive Brownfields Exploration Results at Guanacevi and Bolanitos: Drilling continued to intersect high-grade silver-gold mineralization in the Santa Cruz vein at Guanacevi, and in the Medallito and Belen veins at Bolanitos.

  • Delivered Positive Regional Exploration Result at the Terronera Development Project: Intercepted high-grade silver-gold mineralization in a number of structures near the Terronera vein. The Project Management Team continues to advance the feasibility study, which is expected to be completed during the third quarter of 2021.

Dan Dickson, Endeavour CEO, commented, “I am excited to lead the Endeavour team into the Company’s next chapter. I want to commend our management and employees who have professionally navigated the global pandemic with care and understanding for our fellow workers, business partners and communities. As an organization, our goal is to be a leader in our communities while delivering safe, sustainable production.”

In Q2, Endeavour delivered positive results in operations and exploration and is pushing to advance the Terronera project to a development decision with the completion of the Terronera Feasibility Study in Q3, 2021.”

Mine Operations

Consolidated silver and gold production in Q2, 2021 were both higher than Q2, 2020 due to the suspension of the Guanacevi, Bolanitos and El Compas mines as a result of the COVID-19 pandemic in Q2, 2020. Q2, 2021 production slightly exceeded plan as higher throughput at each operation contributed to the higher production.

Guanacevi throughput exceeded plan and was the highest quarterly throughput since 2014 as operations continued to outperform. Mining the new higher grade El Curse orebodies has led to significantly improved grades and mine plan flexibility. Additionally, supplies of local third-party ores continued to supplement mine production, amounting to 10% of quarterly throughput, and contributed to the higher ore grades.  

Bolanitos and El Compas processed tonnes, were all higher compared to plan, partly offset by slightly lower grades due to normal variations in the ore body. It is expected that grades will align with planned grades over the course of the year. As previously disclosed by the Company (see EDR news release dated January 7, 2021), the existing reserve at El Compas is limited and sufficient to continue mining until mid-2021. Management is currently assessing alternatives, including temporary closure.

COVID-19 pandemic remains relevant in Mexico, and at the Company’s business locations, process and protocols remain in place to ensure staff and workers as well as our communities remain as safe as possible. Vaccination programs are advancing in Mexico to allow a return of a new normal in the second half of this year.

Production Highlights for Three Months and Six Months Ended June 30, 2021

Three Months Ended June 30 Q2 2021 Highlights

 Six Months Ended June 30
2021 2020 % Change 2021 2020 % Change
242,018 114,120 112% Throughput (tonnes) 451,471 313,447 44%
1,073,724 596,545 80% Silver ounces produced 2,121,824 1,454,204 46%
11,166 5,817 92% Gold ounces produced 22,275 14,293 56%
1,062,267 590,618 80% Payable silver ounces produced 2,098,977 1,440,409 46%
10,955 5,717 92% Payable gold ounces produced 21,849 14,037 56%
1,967,004 1,061,905 85% Silver equivalent ounces produced(1) 3,903,824 2,597,644 50%
1,120,266 634,839 76% Silver ounces sold 1,743,645 1,300,339 34%
9,810 5,218 88% Gold ounces sold 20,473 12,672 62%

(1)    Silver equivalent ounces calculated using 80 :1 ratio .

 

Production Tables for Second Quarter, 2021 by Mine ( 
1 
)

Production Tonnes Tonnes Grade Grade Recovery Recovery Silver Gold
by mine Produced per day Ag gpt (1) Au gpt (1) Ag % Au % Oz Oz
Guanaceví 111,893 1,230 308 0.98 84.8% 87.5% 939,241 3,084
Bolañitos 107,912 1,186 39 2.14 88.7% 91.0% 120,044 6,753
El Compas 22,213 244 30 2.45 67.4% 76.0% 14,439 1,329
Consolidated 242,018 2,660 163 1.63 84.9% 87.9% 1,073,724 11,166

(1)  gpt = grams per tonne

 

Production Tables for Six Months Ended June 30, 2021 by Mine ( 
1 
)

Production Tonnes Tonnes Grade Grade Recovery Recovery Silver Gold
by mine Produced per day Ag gpt (1) Au gpt (1) Ag % Au % Oz Oz
Guanaceví 200,525 1,102 335 1.01 86.0% 89.5% 1,857,458 5,827
Bolañitos 205,604 1,130 39 2.15 87.8% 91.0% 226,271 12,935
El Compas 45,342 249 39 3.30 67.0% 73.0% 38,095 3,513
Consolidated 451,471 2,481 170 1.76 85.8% 87.2% 2,121,824 22,275

(2)   gpt = grams per tonne

 

Paloma Drill Results

Endeavour drilling has confirmed widespread alteration and low grade gold mineralization at its Paloma project. The Paloma project is a high-sulphidation, epithermal-style hydrothermal system located in the Chilean Miocene deposit belt, 180 kilometers southeast of the city of Calama, 5,000 metres above sea level. Endeavour has an option to acquire up to 70% ownership of 5,100 hectares from Compañía Minera del Pacifico.

To date, Endeavour completed 5,945 metres of diamond drilling in 13 drill holes. Highlights include 0.4 grams per tonne of gold over 46 metres true width, however it is interpreted that the drilling did not reach the core of the system. The exploration team is currently analyzing the drill results to develop the next phase drill program to test for the possibility of higher grade mineralization.

Management Appointment

Endeavour Silver is pleased to announce that Galina Meleger has been promoted to the position of Vice President of Investor Relations effective July 15th, 2021. Galina has been with Endeavour Silver since 2017 and brings extensive knowledge and leadership to her role with a strong understanding of business goals and a global investor network. Galina Meleger has over 15 years’ experience in the resource sector, in the capacity of investor relations, corporate communications and more recently ESG. During 2021, Galina was the recipient of several industry awards including the “Belle Mulligan Award for Leadership in Investor Relations” from CIRI (Canadian Investor Relations Institute) and the “30 under 40” which honors the most talented individuals in the investor relations community from NIRI (National Investor Relations Institute). Galina’s career history includes successful and highly regarded companies, with international listings, including, Newmarket Gold and then subsequently Kirkland Lake Gold, KGHM, and Copper Mountain Mining Corporation.

Release of Second Quarter, 2021 Financial Results and Conference Call

The 2021 Second Quarter Financial Results will be released before market on Tuesday, August 10, 2021 and a telephone conference call will be held the same day at 10:00am PT (1:00pm ET). To participate in the conference call, please dial the numbers below. No pass code is necessary.

Toll-free in Canada and the US: 1-800-319-4610
Local Vancouver: 604-638-5340
Outside of Canada and the US: +604-638-5340

A replay of the conference call will be available by dialing 1-800-319-6413 in Canada and the US (toll-free) or +604-638-9010 outside of Canada and the US. The required pass code is 7318#. The audio replay and a written transcript will be available on the Company’s website at www.edrsilver.com under the Investor Relations, Events section.

Qualified Person and QA/QC – Dale Mah, P.Geo., Vice President Corporate Development of Endeavour Silver, is the Qualified Person who reviewed and approved the technical information contained in this news release. A Quality Control sampling program of reference standards, blanks and duplicates has been instituted to monitor the integrity of all assay results. All samples are split at the local field office and shipped to SGS Labs, where they are dried, crushed, split and 250 gram pulp samples are prepared for analysis. Gold is determined by fire assay with an atomic absorption (AAS) finish and silver by aqua regia digestion with ICP finish, over-limits by fire assay and gravimetric finish.

About Endeavour Silver – Endeavour Silver Corp. is a mid-tier precious metals mining company that owns and operates three high-grade, underground, silver-gold mines in Mexico. Endeavour is currently advancing the Terronera mine project towards a development decision and exploring its portfolio of exploration and development projects in Mexico and Chile to facilitate its goal to become a premier senior silver producer. Our philosophy of corporate social integrity creates value for all stakeholders.

SOURCE Endeavour Silver Corp.

Contact Information:
Galina Meleger, Director, Investor Relations
Toll free: (877) 685-9775
Tel: (604) 640-4804
Email: [email protected]
Website: www.edrsilver.com

Follow Endeavour Silver on Facebook, Twitter, Instagram and LinkedIn

Cautionary Note Regarding Forward-Looking Statements

Cautionary Note Regarding Forward-Looking Statements

This news release contains “forward-looking statements” within the meaning of the United States private securities litigation reform act of 1995 and “forward-looking information” within the meaning of applicable Canadian securities legislation. Such forward-looking statements and information herein include but are not limited to statements regarding the impact of suspension of mining operations, Endeavour’s anticipated performance in 2021, including production forecasts, cost estimates and metal price estimates, and the timing and results of mine expansion and development and receipt of various permits. The Company does not intend to and does not assume any obligation to update such forward-looking statements or information, other than as required by applicable law.

Forward-looking statements or information involve known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of Endeavour and its operations to be materially different from those expressed or implied by such statements. Such factors include, among others, uncertainty of the ultimate impact of the COVID 19 pandemic on operations, changes in national and local governments, legislation, taxation, controls, regulations and political or economic developments in Canada and Mexico; operating or technical difficulties in mineral exploration, development and mining activities; risks and hazards of mineral exploration, development and mining; metal prices; the speculative nature of mineral exploration and development, risks in obtaining necessary licenses and permits, and challenges to the Company’s title to properties; as well as those factors described in the section “risk factors” contained in the Company’s most recent form 40F/Annual Information Form filed with the S.E.C. and Canadian securities regulatory authorities.

Forward-looking statements are based on assumptions management believes to be reasonable, including but not limited to: the continued operation of the Company’s mining operations, the impact of the COVID 19 pandemic on mining operations in Mexico generally, and the Company’s operations specifically, no material adverse change in the market price of commodities, mining operations will operate and the mining products will be completed in accordance with management’s expectations and achieve their stated production outcomes, resource and reserve estimates, metal prices, and such other assumptions and factors as set out herein. Although the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements or information, there may be other factors that cause results to be materially different from those anticipated, described, estimated, assessed or intended. There can be no assurance that any forward-looking statements or information will prove to be accurate as actual results and future events could differ materially from those anticipated in such statements or information. Accordingly, readers should not place undue reliance on forward-looking statements or information.

Source: Endeavour Silver Corporation

Seanergy Maritime (SHIP) – High-Grading Transactions Announced

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Thursday, July 08, 2021

Seanergy Maritime (SHIP)
High-Grading Transactions Announced

Seanergy Maritime Holdings Corp., an international shipping company, provides marine dry bulk transportation services through the ownership and operation of dry bulk vessels. Seanergy Maritime Holdings Corp. is the only pure-play Capesize shipping company listed in the US capital markets. Seanergy provides marine dry bulk transportation services through a modern fleet of 10 Capesize vessels, with total capacity of approximately 1,748,581 dwt and an average fleet age of about 9.8 years. The Company is incorporated in the Marshall Islands with executive offices in Athens, Greece and an office in Hong Kong. The Company’s common shares trade on the Nasdaq Capital Market under the symbol “SHIP” and class A warrants under “SHIPW”.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

    Another Cape acquisition announced. A 2009-built Cape, to be named Friendship, will be acquired shortly for $24.6 million. The acquisition will be funded with cash on hand, but future debt financing in the 50% range is likely, similar to the other acquisitions completed this year. The acquisition, combined with the divestiture, should have a positive impact on the fleet profile, with the average age of the Capes dropping to 11.4 years.

    Partial offset with net proceeds from sale of oldest Cape.  In conjunction with the acquisition, the Friendship, a 2001-built Cape, will be sold for ~$12 million. The sale, which avoids an upcoming survey, should net ~$6 million after paying off secured debt of ~$6 million …



This research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary.  Proper due diligence is required before making any investment decision. 

Palladium One Mining Inc. (NKORF)(PDM:CA) – Recent IP Surveys Yield Positive Implications for LK Project Resource Potential

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Thursday, July 08, 2021

Palladium One Mining Inc. (NKORF)(PDM:CA)
Recent IP Surveys Yield Positive Implications for LK Project Resource Potential

Palladium One Mining Inc is a palladium dominant, PGE, nickel, copper exploration and development company. Its assets consist of the Lantinen Koillismaa and Kostonjarvi PGE-Cu-Ni projects, located in north-central Finland and the Tyko Ni-Cu-PGE and Disraeli PGE-Ni-Cu properties in Ontario, Canada. LK is targeting disseminated sulphide along 38 kilometers of favorable basal contact. The KS project is targeting massive sulphide within a 20,000-hectare land package covering a regional scale gravity and magnetic geophysical anomaly. Tyko is a 13,000-hectare project targeting disseminated and massive sulphide in a highly metamorphosed Archean terrain. Disraeli is a 2,500-hectare project targeting PGE-rich disseminated and massive sulphide in a highly productive Proterozoic mid-continent rift.

Mark Reichman, Senior Research Analyst of Natural Resources, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

    IP surveys underscore Kaukua South resource potential. Results from two recent induced polarization (IP) surveys confirmed an increase in the Kaukua South IP chargeability anomaly to over 7 kilometers in strike length from the initial 4 kilometer area where drilling has returned impressive drill results and confirmed mineralization. The anomaly has been extended northwest and to the south of the Kaukua pit-constrained resource offering the potential for an expanded Kaukua open pit.

    Putting it into perspective.  An existing NI 43-101 compliant Kaukua pit constrained resource of 635,600 ounces of indicated palladium equivalent resources and 525,800 inferred palladium equivalent resources only covers a strike length of 1 kilometer. The western grid survey indicated there may be an opportunity to significantly widen the existing Kaukua Pit, and the detection of a significant …



This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary.  Proper due diligence is required before making any investment decision. 

Release – Allegiant to Acquire Land Adjacent to Recent High-Grade Gold Discovery at Eastside

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Allegiant to Acquire Land Adjacent to Recent High-Grade Gold Discovery at Eastside

RENO, Nev., July 07, 2021 (GLOBE NEWSWIRE) — Allegiant Gold Ltd. (“Allegiant” or the
“Company”) (AUAU: TSX-V) (AUXXF: OTCQX) is pleased to have entered into a lease with option to purchase agreement (“Agreement”) to acquire 84 claims located to the west of the Original Pit Zone at Eastside (see map below), nearby the recent high-grade discovery announced by Allegiant on May 26, 2021. Highlights included:

  • Hole 243 — 148 metres (486
    feet) of 2.6 grams per tonne gold:
    • Including 14 metres (45 feet)
      of 21.9 grams per tonne gold;
    • Including 20 metres (65 feet)
      of 173.8 grams per tonne silver;
  • Hole 239 — three metres (10
    feet) of 39.0 grams per tonne gold.

Peter Gianulis, CEO of
Allegiant Gold, commented: “We are very pleased to have reached an agreement with a private individual to acquire these additional claims that are adjacent to our current claims. With this addition, Eastside now consists of 973 claims or approximately 80 km2 in one of the most prolific areas of Nevada, the Walker Lane Trend. Our most recent drilling campaign has given us more confidence that the western edge of the Original Pit Zone at Eastside is host to the higher-grade zones.”

Map 1: 84 Additional Claims Location

The closing of the transaction may be subject to final TSXV approval.

QUALIFIED PERSON

Andy Wallace is a Certified Professional Geologist (CPG) with the American Institute of Professional Geologists and is the Qualified Person under NI 43-101, Standards of Disclosure for Mineral Projects, who has reviewed and approved the scientific and technical content of this press release.

ABOUT ALLEGIANT

Allegiant owns 100% of 10 highly-prospective gold projects in the United States, 7 of which are located in the mining-friendly jurisdiction of Nevada. Four of Allegiant’s projects are farmed-out, providing for cost reductions and cash-flow. Allegiant’s flagship, district-scale Eastside project hosts a large and expanding gold resource and is located in an area of excellent infrastructure. Preliminary metallurgical testing indicates that both oxide and sulphide gold mineralization at Eastside is amenable to heap leaching.

ON BEHALF OF THE BOARD

Peter Gianulis
CEO

For more information contact:

Investor Relations
(604) 634-0970 or
1-888-818-1364

[email protected]

Neither TSX Venture
Exchange nor its Regulation Services Provider (as that term is defined in
policies of the TSX Venture Exchange) accepts responsibility for the adequacy
or accuracy of this release.

Certain statements and
information contained in this press release constitute “forward-looking
statements” within the meaning of applicable U.S. securities laws and
“forward-looking information” within the meaning of applicable Canadian
securities laws, which are referred to collectively as “forward-looking
statements”. The United States Private Securities Litigation Reform Act of
1995 provides a “safe harbor” for certain forward-looking statements. Allegiant Gold Ltd.’s (“Allegiant”)
exploration plans for its gold exploration properties, the drill program at
Allegiant’s Eastside project, the preparation and publication of an updated
resource estimate in respect of the Original Zone at the Eastside project,
Allegiant’s future exploration and development plans, including anticipated
costs and timing thereof; Allegiant’s plans for growth through exploration
activities, acquisitions or otherwise; and expectations regarding future
maintenance and capital expenditures, and working capital requirements. 
Forward-looking statements are statements and information regarding possible
events, conditions or results of operations that are based upon assumptions
about future economic conditions and courses of action. All statements and
information other than statements of historical fact may be forward-looking
statements. In some cases, forward-looking statements can be identified by the
use of words such as “seek”, “expect”, “anticipate”, “budget”, “plan”,
“estimate”, “continue”, “forecast”, “intend”, “believe”, “predict”,
“potential”, “target”, “may”, “could”, “would”, “might”, “will” and similar
words or phrases (including negative variations) suggesting future outcomes or
statements regarding an outlook. Such forward-looking statements are based on a
number of material factors and assumptions and involve known and unknown risks,
uncertainties and other factors which may cause actual results, performance or
achievements, or industry results, to differ materially from those anticipated
in such forward-looking information. You are cautioned not to place undue
reliance on forward-looking statements contained in this press release. Some of
the known risks and other factors which could cause actual results to differ
materially from those expressed in the forward-looking statements are described
in the sections entitled “Risk Factors” in Allegiant’s Listing Application,
dated January 24, 2018, as filed with the TSX Venture Exchange and available on
SEDAR under Allegiant’s profile at www.sedar.com. Actual results and future
events could differ materially from those anticipated in such statements.
Allegiant undertakes no obligation to update or revise any forward-looking
statements included in this press release if these beliefs, estimates and
opinions or other circumstances should change, except as otherwise required by
applicable law.

 

Release – Palladium One IP Anomaly Increased over 75 Percent, to more than 7 km at Kaukua South, Finland

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Palladium One IP Anomaly Increased over 75%, to more than 7 km at Kaukua South, Finland

Highlights

  • Kaukua South IP anomaly expanded to over 7 kilometers in length, from ~4 kilometers.
  • IP has proven to be a reliable tool for targeting high-grade mineralization.
  • A new and, the largest and strongest
    anomaly     in the Kaukua area has been discovered immediately west of the NI43-101 Kaukua pit-constrained Resource.
  • Additionally, a new large IP anomaly has been discovered on the far east side of Kaukua South. This may represent a new high-grade core zone of mineralization.
  • The Kaukua South IP anomaly has been extended northwest and to the south of the Kaukua pit-constrained Resource, thereby potentially allowing for a significant expansion of the envisioned Kaukua open-pit.
  • First release of a detailed Kaukua South long section.

July 07, 2021 – Toronto,
Ontario – Two additional Induced Polarization (“IP’) surveys were carried out in the Greater Kaukua Area to expand the known 4-kilometer long Kaukua South IP anomaly on both it’s eastern and western ends (see news release 
March
11, 2021). The results of the new surveys confirm an over 75% increase in the Kaukua South IP chargeability anomaly, which is now greater than 
7 kilometers in strike length, said Palladium One Mining Inc. (“Palladium One” or the “Company”) (TSXV: PDM, FRA: 7N11, OTC: NKORF) today. Drilling to date has confirmed extensive mineralization over the initial 4-kilometer Kaukua South anomaly, the 3-kilometer expansion suggests a much large resource endowment is possible (see Long Section – Figure 3)

Derrick Weyrauch, President and CEO of Palladium One said, “These new IP survey results highlight how robust the mineralized system is in the greater Kaukua area. In 2019, the Kaukua zone was only 1.2 kilometers long, we have now outlined a zone of over 7 kilometers in length, drilled and proven mineralization over 4 kilometers of strike length and are nearing completion of infill drilling in advance of a maiden NI43-101 resource for a 2-kilometer portion of the Kaukua South zone.”

IP has proven to be a reliable technique for discovering and outlining shallow higher grade PGE-Ni-Cu mineralization at Kaukua and elsewhere on the LK project. The
NI43-101 Kaukua pit constrained Resource and the Kaukua South zone were both
discovered as a result of testing IP chargeability anomalies. The Kaukua Resource only covers a strike length of 1 kilometer, whereas the LK project includes approximately 38 kilometers of strike length of the favourable basal unit in the Koillismaa mafic ultramafic complex.

Kaukua National Instrument
43-101 pit constrained Resource Estimate (see news release September
9, 2019)

Class

Tonne
(kt)

Pd
g/t

Pt
g/t

Au g/t

PGE
(Pd+Pt+A)
g/t

Ni  %

Cu %

Pd_Eq*

Spot
Au_Eq**
g/t

Spot
Cu_Eq**
%

g/t

Oz

Indicated

10,985

0.81

0.27

0.09

1.17

0.09

0.15

1.80

635,600

2.02

1.32

Inferred

10,875

0.64

0.20

0.08

0.92

0.08

0.13

1.50

525,800

1.64

1.08

Selection of previously
released Kaukua South drill results:

  • 63 meters grading 3.5 g/t Palladium
    equivalent*     (4.1 g/t Gold equivalent**, 2.5% Copper equivalent**) in hole LK20-016 (see news release October 22, 2020)
  • 53 meters grading 2.1 g/t Palladium
    equivalent*     (2.3 g/t Gold equivalent**, 1.4% Copper equivalent**) in hole LK20-028 (see news release January 18, 2021)
    • 
    47 meters grading 2.6 g/t
    Palladium equivalent*     (2.9 g/t
    Gold equivalent**    , 1.8% Copper equivalent** ) in hole LK20-045 (see news release March 18, 2021)

Hole

From (m)

To (m)

Width (m)

Pd g/t

Pt g/t

Au g/t

Cu %

Ni %

LK20-016

23.5

86.2

62.7

1.84

0.64

0.14

0.18

0.15

LK20-028

42.6

95.5

52.9

1.00

0.36

0.08

0.11

0.11

LK20-045

122.8

170.2

47.4

1.20

0.42

0.11

0.17

0.14

Including the recent surveys, the Company completed a total of 143 kilometers of IP on the LK Project. The 2021 IP surveys were a follow up to the highly successful 2020 survey which resulted in the discovery of Kaukua South. The current surveys consisted of two grids (Figure 1 and 2.).

Kaukua West IP Survey Grid
The objective of this survey was to extend the Kaukua South anomaly further to the west (Figure 1).

The survey indicates Kaukua South swings northwest and possibly parallel the Kaukua Resource Pit. This is an important drill target as little drilling has been done in this area, and if mineralization is found it could substantially widen the existing Kaukua Pit.

Additionally, this survey detected a significant IP anomaly to the west of a fault that was thought to cut off the Kaukua Resource Pit. This is the strongest
IP response within the whole Greater Kaukua Area and could represent the chance
to discover high-grade mineralization that could support an underground
PGE-Ni-Cu mine.

Figure 1. Western half of > 7 kilometer Long IP chargeability anomaly. Showing the new Kaukua West survey area.

Kaukua East IP Survey Grid
The objective of this survey was to extend the Kaukua South anomaly at least two kilometers to the east (Figure 2).

Regional airborne magnetic data strongly suggested that favourable Kaukua-style mafic-ultramafic hosts rocks extend into this area. This hypothesis appears to be correct with a strong chargeability anomaly located on the far eastern side of the grid. This anomaly is a significant drill target and may represent another higher-grade core zone similar to the western portion of Kaukua South.

Figure 2. Eastern half of the > 7 kilometer IP chargeability anomaly showing the Kaukua East survey area

Figure 3. Kaukua South Long Section having a drill data cut-off date of February 16, 2021 (hole LK20-066). This section covers only the western portion of Kaukua South for which the Company plans to report an initial NI43-101 resource estimate in Q1 2022. The section is a vertical slice representing only the ~55° south dipping Lower Zone of Kaukua South. Intercepts are represented in both width (meters) and palladium equivalent (Pd_Eq*) grade as well as gram*meters (grade*width).

*Palladium
Equivalent (Pd_Eq)
Palladium equivalent is calculated using US$1,100 per ounce for palladium, US$950 per ounce for platinum, US$1,300 per ounce for gold, US$6,614 per tonne for copper, and US$15,4332 per tonne for nickel. This calculation is consistent with the calculation in the Company’s September 2019 NI 43-101 Kaukua resource estimate. Additionally, US$1,100 per ounce for palladium is consistent with the UBS January 2021 long-term consensus price forecast even though the current price of palladium is approximately US$2,800 per ounce.

**Spot Palladium, Copper and
Gold Equivalent
Spot palladium and gold equivalents are calculated using recent spot prices for comparison purposes using US$2,730 per ounce for palladium, US$1,090 per ounce for platinum, US$1,790 per ounce for gold, US$9,259 per tonne for copper, and US$18,298 per tonne for nickel

Qualified
Person
The technical information in this release has been reviewed and verified by Neil Pettigrew, M.Sc., P. Geo., Vice President of Exploration and a director of the Company and the Qualified Person as defined by National Instrument 43-101.

About Palladium One
Palladium One Mining Inc. is an exploration company targeting district scale, platinum-group-element (PGE)-copper nickel deposits in Finland and Canada. Its flagship project is the Läntinen Koillismaa or LK Project, a palladium dominant platinum group element-copper-nickel project in north-central Finland, ranked by the Fraser Institute as one of the world’s top countries for mineral exploration and development. Exploration at LK is focused on targeting disseminated sulfides along 38 kilometers of favorable basal contact and building on an established NI 43-101 open pit resource.

ON
BEHALF OF THE BOARD
“Derrick Weyrauch”
President & CEO,
Director

For
further information contact: Derrick Weyrauch, President & CEO
Email: [email protected]

Neither
the TSX Venture Exchange nor its Market Regulator (as that term is defined in
the policies of the TSX Venture Exchange) accepts responsibility for the
adequacy or accuracy of this release.

This
press release includes “forward-looking information” that is subject
to a few assumptions, risks and uncertainties, many of which are beyond the
control of the Company. Statements regarding listing of the Company’s common
shares on the TSXV are subject to all of the risks and uncertainties normally
incident to such events. Investors are cautioned that any such statements are
not guarantees of future events and that actual events or developments may
differ materially from those projected in the forward-looking statements. Such
forward-looking statements represent management’s best judgment based on
information currently available. Factors that could cause the actual results to
differ materially from those in forward-looking statements include regulatory
actions and general business conditions. Such forward-looking information
reflects the Company’s views with respect to future events and is subject to
risks, uncertainties and assumptions, including those set out in the Company’s
annual information form dated April 29, 2020 and filed under the Company’s
profile on SEDAR at www.sedar.com.
The Company does not undertake to update forward?looking statements or forward?looking information, except as
required by law. Investors are cautioned that any such statements are not
guarantees of future performance and actual results or developments may differ
materially from those projected in the forward-looking statements.

Stem Cell-Derived Retinal Pigment Epithelium Cells – Vision for the Future

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	Image Credit: pudgeefeet (flickr)


Stem Cell-Derived Epithelium Cells May Reveal Light at the End of the Tunnel

 

Human retinal pigment epithelium cells made from stem cells in the lab hold promise in restoring
vision

 

Blindness, eye diseases, and vision impairment

As part of the Global Burden of Disease study, epidemiologists estimated that in 2020, 43.3 million people worldwide were blind1. The leading global causes of blindness in individuals aged 50 years and older in 2020 were:

  • Cataracts
  • Glaucoma
  • Undercorrected refractive error
  • Age-related macular degeneration
  • Diabetic retinopathy

In the U.S. (2015), about 1.02 million people were blind, and roughly 3.22 million people had impaired vision2. According to data from the CDC’s Disability and Health Data System (2019), the nationwide prevalence of ‘vision disability’ was 5%3. The CDC predicts that the population of adults with blindness and vision impairment will double due to the rapidly aging population, coupled with the increasing incidence of diabetes and other chronic diseases that contributes to vision loss4.

Vision loss is a debilitating condition that affects both patients and family members. Loss of sight negatively impacts one’s quality of life, independence, mobility, emotional wellbeing, social function, and even cognitive capabilities5. The economic burden of blindness and vision impairment is also significant – the total economic cost was estimated to be about $139 billion (2013) in the U.S6. Vision impairment does not only affect visual health; it also correlates with poorer physical (falls, injury, worsening of other chronic conditions) and mental health (depression, anxiety7). Vision loss alone resulted in the loss of 283 000 disability-adjusted life years (DALYs)6. Therefore, the disease burden8 of blindness and vision impairment remains to be a public health concern.

 

Age-related macular degeneration

Macular degeneration, also known as age-related macular degeneration (AMD), is a neurodegenerative disease that is one of the leading causes of blindness and vision impairment. Advanced age is a major risk factor of AMD; therefore, AMD primarily affects elderly individuals. About 11 million individuals are affected with AMD in the U.S, and by 2050, the number is expected to increase to 22 million9. Patients with AMD have damage to the macula, a part of the retina, resulting in a progressive loss of central vision. There are two types of AMD – dry and wet AMD. Dry AMD is characterized by the thinning of the macula over time, gradually resulting in vision loss. Dry AMD is the more common, accounting for 70-90% of AMD cases10. Wet AMD is a late-stage AMD where abnormal blood vessels grow in the back of the eye, causing damage to the macula. Currently, there are several treatment options for wet AMD, such as anti-VEGF drugs and photodynamic therapy11. However, the main goal of those treatment options is to prevent the growth of blood vessels or to seal abnormal blood vessels underneath the macula in order to preserve existing vision and prevent further deterioration of vision. Those treatments are not designed to restore vision. In addition, there are no treatments for early or late dry AMD.

 

Retinal
cell therapy for treating retinal diseases

The use of retinal cell replacement therapy has recently been explored as a feasible treatment option for retinal diseases that underly vision loss, such as AMD and even glaucoma. Human retinal pigment epithelium (RPE) is a layer of pigmented cells that play several critical roles in supporting photoreceptor function and maintaining visual function12. Retinal degeneration seen in retinal diseases, such as in the case of AMD, results in vision impairment. Therefore, retinal cell replacement therapy aims to replace damaged or diseased RPE cells with healthy, functioning ones in order to improve or even restore visual function.

 

Sources of
human retinal pigment
epithelium cells

There are a few sources of human RPE cells that could be used for retinal cell replacement therapy:

  • Adult RPE isolated from cadaveric donors13
  • Fetal RPE or retinal progenitor cells (RPCs) isolated from fetal eyes14
  • Immortalized adult RPE cells that are manipulated such that the cells are able to proliferate and grow continuously. 

However, there are disadvantages to using these cells. It is difficult to culture adult RPE cells in the lab as they readily lose their functional properties and molecular signatures. Fetal RPE cells were able to better preserve their function when cultured in vitro; they were pigmented, uniform in size and shape, and retained their molecular signatures15. Lastly, both adult RPE cells and fetal RPE cells are limited in numbers and largely depend on the availability of donors. Although immortalized adult RPE can be easily cultured in vitro and be generated in large numbers, they do not physiologically represent actual RPE cells and may pose cancer risks when used for replacement therapy. Most importantly, experiments involving the use of these cells for retinal cell replacement therapy did not result in vision recovery16.

 

Generating human retinal pigment epithelium cells from human pluripotent stem cells (hPSCs) in the lab

Human pluripotent stem cells (hPSCs) such as human embryonic stem cells (hESCs) and human-induced pluripotent stem cells (iPSCs) have emerged to be a viable and sustainable source of human RPE cells. hPSCs are, by definition, capable of differentiating into any cell type in the body and are self-renewal, which means that they are able to proliferate while retaining their pluripotency. This essentially means that hPSCs could be used to generate an unlimited supply of human RPE cells for retinal cell replacement therapy.

Over the past decade, efforts have been channeled into developing a differentiation protocol to generate human retinal pigment epithelium (RPE) cells from hPSCs. Masayo Takahashi, a pioneer in stem cell-derived RPE cells from Japan’s RIKEN Institute, came up with ways to generate RPE cells as well as RPE sheets from human iPSCs. The RPE sheets were shown to express molecular signatures and exhibit characteristics similar to native RPE. They also showed upon transplantation of iPSC-derived RPE sheets into nonhuman primates, no adverse effects were reported. Earlier this year, researchers from Singapore also showed that stem cell-derived RPE cells (monolayers) that were transplanted under the macula of nonhuman primates were able to survive and maintain healthy photoreceptors17. In another study, when human iPSCs-derived RPE cells were transplanted in a rat model of retinal degeneration, visual function in these rats was rescued18. Recently, researchers have even developed methods to generate 3-D retina organoids that improve visual function when transplanted into animal models of RPE dysfunction19.

 

Clinical trials

There are already several past and ongoing clinical trials for retinal cell replacement therapy, conducted by biotech companies, research institutions, and even big pharmas16,20. More recently, the National Eye Institute (NEI) of the National Institute of Health (NIH) launched the first U.S. clinical trial of iPSC-derived RPE cells for the treatment of dry AMD21. They will be reprogramming patients’ blood cells into iPSCs before differentiating the iPSCs into RPE cells. The cells will then be grown in one-cell thick sheets (on a biodegradable biological scaffold) before transplantation into the eyes of the patients.

However, the first-ever retinal cell replacement therapy was performed in Japan on a 70—year old Japanese woman22. This experiment was conducted by a group of researchers led by Takahashi. The patient’s skin cells were first reprogrammed into iPSCs, and the iPSCs were then differentiated into RPE cells and transplanted into the patient’s eyes. Takahashi and colleagues performed a similar experiment in 2017 where they transplanted patient iPSC-derived RPE cells into a patient with wet AMD23.

 

Moving forward

There is light at the end of the tunnel – stem cell-derived RPE holds great promise in treating retinal diseases and restoring vision caused by underlying retinal dysfunctions. With the NIH, biotech companies, and pharmaceutical giants pouring in large amounts of resources into performing research and clinical trials to test the efficacy and safety of stem cell-derived RPE cells for retinal cell replacement therapy, stem cell-derived RPE as a treatment option will soon be a reality. 

 

About the Author:  Nicole Pek is a stem cell biologist and enthusiastic science communicator. She has worked on using human pluripotent stem cells to study cellular development in multiple organ systems, to model complex human diseases, and screen for therapeutics that could treat the diseases. Outside of
the lab, Nicole plays a pro-active role in communicating to the public through her science blog ‘Two Cells’ and her education podcast ‘The Diploid Duo’.

 

References

1.   Bourne, R. et al. Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study. The Lancet Global Health
9, e130–e143 (2021).

2.   Varma, R. et al. Visual Impairment and Blindness in Adults in the United States: Demographic and Geographic Variations From 2015 to 2050. JAMA Ophthalmol 134, 802–809 (2016).

3.   CDC. Disability and Health Data System (DHDS) | CDC. Centers for Disease Control and Prevention https://www.cdc.gov/ncbddd/disabilityandhealth/dhds/index.html (2021).

4.   Burden of Vision Loss | CDC. https://www.cdc.gov/visionhealth/risk/burden.htm (2020).

5.   National Academies of Sciences, E. et al. The Impact of Vision Loss. Making Eye
Health a Population Health Imperative: Vision for Tomorrow (National Academies Press (U.S.), 2016).

6.   Witteborn, John, R., David. The Future of Vision: Forecasting the Prevalence and Cost of Vision Problems. (2014).

7.   Demmin, D. L. & Silverstein, S. M. Visual Impairment and Mental Health: Unmet Needs and Treatment Options. Clin Ophthalmol 14, 4229–4251 (2020).

8.   Gordois, A. et al. An estimation of the worldwide economic and health burden of visual impairment.
Global Public Health 7, 465–481 (2012).

9.   Pennington, K. L. & DeAngelis, M. M. Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors. Eye
Vis (Lond) 3, 34 (2016).

10.   Common Eye Disorders and Diseases | CDC. https://www.cdc.gov/visionhealth/basics/ced/index.html (2020).

11.   Age-related macular degeneration (AMD) – Treatments. nhs.uk https://www.nhs.uk/conditions/age-related-macular-degeneration-amd/treatment/ (2017).

12.   Strauss, O. The Retinal Pigment Epithelium in Visual Function. Physiological Reviews 85, 845–881 (2005).

13.   Akrami, H. et al. Retinal Pigment Epithelium Culture;a Potential Source of Retinal Stem Cells. J
Ophthalmic Vis Res 4, 134–141 (2009).

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al. Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue. Invest Ophthalmol Vis
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15.   Ablonczy, Z. et al. Human Retinal Pigment Epithelium Cells as Functional Models for the RPE In Vivo. Invest. Ophthalmol. Vis. Sci. 52, 8614–8620 (2011).

16.   Oswald, J. & Baranov, P. Regenerative medicine in the retina: from stem cells to cell replacement therapy. Ther Adv Ophthalmol 10, 2515841418774433 (2018).

17.   Liu, Z. et al. Surgical Transplantation of Human RPE Stem Cell-Derived RPE Monolayers into Non-Human Primates with Immunosuppression. Stem Cell Reports 16, 237–251 (2021).

18.   Surendran, H. et
al. Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration. Stem Cell Research
& Therapy 12, 70 (2021).

19.   Lin, B. et al. Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction. Invest Ophthalmol Vis Sci 61, 34 (2020).

20.   Zarbin, M., Sugino, I. & Townes-Anderson, E. Concise Review: Update on Retinal Pigment Epithelium Transplantation for Age-Related Macular Degeneration. STEM CELLS Translational
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21.   NIH launches first U.S. clinical trial of patient-derived stem cell therapy to replace and repair dying cells in retina | National Eye Institute. https://www.nei.nih.gov/about/news-and-events/news/nih-launches-first-us-clinical-trial-patient-derived-stem-cell-therapy-replace-and-repair-dying.

22.   Cyranoski, D. Japanese woman is first recipient of next-generation stem cells. Nature (2014) doi:10.1038/nature.2014.15915.

23.   First donor iPSC-derived RPE cell transplantation in AMD patient Center for Developmental Biology | RIKEN CDB. http://www.cdb.riken.jp/en/news/2017/topics/0404_10343.html.

 

Suggested Reading

The Investor Forum at the World Stem Cell Summit

Stem Cells Role in the Anti Aging Business



Therapeutic Research Advanced by Stem Cell Science

Why Stem Cell Stocks in 2021 Make Sense

 

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Release – Energy Fuels and Neo Performance Materials Announce Contract Signing and Launch of Commercial Shipments of Rare Earth Product to Europe in Emerging U.S.-Based Rare Earth Supply Chain

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Energy Fuels and Neo Performance Materials Announce Contract Signing and Launch of Commercial Shipments of Rare Earth Product to Europe in Emerging U.S.-Based Rare Earth Supply Chain

TORONTO, ON and LAKEWOOD, Colo., July 7, 2021 /CNW/ – Energy
Fuels Inc. (NYSE American: UUUU) (TSX: EFR) (“Energy Fuels”) and Neo Performance Materials Inc. (TSX: NEO) (“Neo”) are pleased to announce that the first container (approximately 20 tonnes of product) of an expected 15 containers  of mixed rare earth carbonate (“RE Carbonate”) has been successfully produced by Energy Fuels at its White Mesa Mill in Utah (the “Mill”) and is en route to Neo’s rare earth separations facility in Estonia, creating a new United States-to-Europe rare earth supply chain.  Additional shipments of RE Carbonate are expected as Energy Fuels continues to process natural monazite sand ore (“Monazite”) mined in Georgia (U.S.) by Chemours (NYSE: CC) for both the rare earth elements and naturally occurring uranium that it contains.

This new supply chain will initially produce rare earth products from monazite that is processed into RE Carbonate at Energy Fuels’ Mill in Utah.  The RE Carbonate is then processed by Neo at its Silmet rare earth processing facility in Sillamäe, Estonia (“Silmet”) into separated rare earth oxides and other value-added rare earth compounds.  Neo is the only commercial producer of separated rare earth oxides in Europe.

Monazite, which is produced as a byproduct of existing heavy mineral sands mining, also contains naturally occurring uranium that Energy Fuels recovers for use in the generation of carbon-free nuclear energy.

This commercial-scale production of RE Carbonate by Energy Fuels from a U.S. mined rare earth resource positions Energy Fuels as the only company in North America that currently produces a Monazite-derived, enhanced rare earth material.  The physical delivery of this product also represents the launch of a new, environmentally responsible rare earth supply chain that allows for source validation and tracking from mining through to final end-use applications for manufacturers in North America, Europe, Japan, and other nations.

Energy Fuels and Neo are further pleased to announce the signing of a definitive supply agreement (the “Agreement”) by the companies’ respective affiliates. Under the Agreement, Colorado-based Energy Fuels will ship all or a portion of its RE Carbonate to Neo’s Silmet rare earth separations facility. Neo will then process Energy Fuels’ RE Carbonate into separated rare earth materials for use in rare earth permanent magnets and other rare earth-based advanced materials. Because of increasing demand for value-added rare earth materials in European manufacturing, Toronto-based Neo seeks to expand and diversify its current supplies of rare earth feedstock at Silmet, which is the only operational rare earth separations facility in Europe. Silmet has been separating rare earths into commercial value-added products for more than 50 years.

Representatives from both Energy Fuels and Neo were on hand at the White Mesa Mill to celebrate the launch of this new critical supply chain.

In addition to supplying RE Carbonate to Neo, Energy Fuels is also evaluating the potential to develop its own separation capabilities at its White Mesa Mill in Utah (U.S.), or nearby, and possibly adding metals, alloys, and rare earth permanent magnets manufacturing capabilities. As a first step, the Company has hired the French firm, Carester SAS, a leading global expert in rare earth separation and supply chains, to produce a scoping study including capital and operating costs for a full rare earth separations capability at the White Mesa Mill, which would be the next important step towards fully integrating a U.S. rare earth supply chain in the coming years, in addition to continuing to supply RE Carbonate to European markets over the long-term.

“The launch of this new supply chain is a real gamechanger for Neo and our growing customer base in Europe,” said Constantine Karayannopoulos, Neo’s Chief Executive Officer.  “This innovative U.S.-to-Europe supply chain will supplement Neo’s existing rare earth supply from our long-time Russian supplier.  It will enable Neo to expand value-added rare earth production in Estonia to meet growing demand in Europe for these materials.  It begins to unlock the extraordinary economic and environmental potential presented by utilizing low-cost rare earth feedstock from monazite ore that is a byproduct of existing mining.  And, it helps Neo ramp up rare earth production in Estonia just as Europe accelerates vehicle electrification and other initiatives aimed at mitigating climate impacts.”

“Today, Energy Fuels and Neo took significant steps toward restoring critical U.S. and European rare earth supply chains,” stated Mark S. Chalmers, President and CEO of Energy Fuels. “Energy Fuels has methodically ramped up our mixed rare earth carbonate production since we first started feeding Georgia monazite ore into our Utah mill in March. Successfully producing this rare earth product, and physically delivering the first containers of Rare Earth Carbonate to Neo, is an important achievement, not only for Energy Fuels and Neo, but also for U.S. government efforts to restore critical rare earth supply chains. This is also very good news for end-users of rare earth products in the U.S., Europe, Japan and elsewhere who seek alternative sources of rare earths produced in the U.S. and Europe to the highest global standards of environmental protection and sustainability.”

Significant quantities of Monazite are produced around the world as a byproduct of zircon and titanium production from heavy mineral sand operations, including large resources in the U.S., Australia, Brazil, South Africa, and other nations. Energy Fuels is in discussions with several parties to secure additional quantities of Monazite that it can use to expand this quickly emerging rare earth initiative. Energy Fuels has a goal of processing 15,000 tons of Monazite or more per year in the future. For perspective, 15,000 tons of Monazite per annum would contain rare earths equal to roughly 50% of total current U.S. demand, while only utilizing approximately 2% of the White Mesa Mill’s existing throughput capacity and less than 1% of its existing tailings capacity. 

Monazite from the southeast U.S. typically contains roughly 55% total rare earth oxides (“TREO”) of which the magnetic elements neodymium and praseodymium (“NdPr”) comprise approximately 22% of the TREO. NdPr are among the most valuable of the rare earth elements, as they are the key ingredient in the manufacture of high-strength permanent magnets that are essential to the lightweight and powerful motors required in electric vehicles, permanent magnet wind turbines used for renewable energy generation, and a variety of other modern technologies, including, mobile devices and defense applications. U.S. Monazite also contains approximately 14.4% “heavy” rare earths on a TREO basis, including roughly 1.5% dysprosium and terbium which have additional important magnet and national defense applications.

ABOUT NEO PERFORMANCE MATERIALS

Neo manufactures the building blocks of many modern technologies that enhance efficiency and sustainability. Neo’s advanced industrial materials — magnetic powders and magnets, specialty chemicals, metals, and alloys — are critical to the performance of many everyday products and emerging technologies. Neo’s products help to deliver the technologies of tomorrow to consumers today. The business of Neo is organized along three segments: Magnequench, Chemicals & Oxides and Rare Metals. Neo is headquartered in Toronto, Ontario, Canada; with corporate offices in Greenwood Village, Colorado, US; Singapore; and Beijing, China. Neo operates globally with sales and production across 10 countries, being Japan, China, Thailand, Estonia, Singapore, Germany, United Kingdom, Canada, United States, and South Korea. For more information, please visit www.neomaterials.com.

ABOUT ENERGY FUELS

Energy Fuels is a leading U.S.-based uranium mining company, supplying U3O8 to major nuclear utilities. Energy Fuels also produces vanadium from certain of its projects, as market conditions warrant, and is ramping up to commercial production of REE carbonate in 2021. Its corporate offices are in Lakewood, Colorado, near Denver, and all of its assets and employees are in the United States. Energy Fuels holds three of America’s key uranium production centers: the White Mesa Mill in Utah, the Nichols Ranch in-situ recovery (“ISR”) Project in Wyoming, and the Alta Mesa ISR Project in Texas. The White Mesa Mill is the only conventional uranium mill operating in the U.S. today, has a licensed capacity of over 8 million pounds of U3O8 per year, has the ability to produce vanadium when market conditions warrant, as well as REE carbonate from various uranium-bearing ores. The Nichols Ranch ISR Project is on standby and has a licensed capacity of 2 million pounds of U3O8 per year. The Alta Mesa ISR Project is also on standby and has a licensed capacity of 1.5 million pounds of U3O8per year. In addition to the above production facilities, Energy Fuels also has one of the largest NI 43-101 compliant uranium resource portfolios in the U.S. and several uranium and uranium/vanadium mining projects on standby and in various stages of permitting and development. The primary trading market for Energy Fuels’ common shares is the NYSE American under the trading symbol “UUUU,” and the Company’s common shares are also listed on the Toronto Stock Exchange under the trading symbol “EFR.” Energy Fuels’ website is www.energyfuels.com.

CAUTIONARY STATEMENTS REGARDING FORWARD LOOKING STATEMENTS

This news release contains “forward-looking information” within the meaning of applicable securities laws in Canada and the United States. Forward-looking information may relate to future events or future performance of Neo or Energy Fuels. All statements in this release, other than statements of historical facts, with respect to Neo’s or Energy Fuels’ objectives and goals, as well as statements with respect to their beliefs, plans, objectives, expectations, anticipations, estimates, and intentions, are forward-looking information. Specific forward-looking statements in this discussion include, but are not limited to, the following: any expectation that the White Mesa Mill will continue to be successful in producing RE Carbonate on a commercial basis; any expectation that Silmet will be successful in separating the White Mesa Mill’s RE Carbonate on a commercial basis; any expectations with regard to the cost of producing and separating RE Carbonate; any expectation that Energy Fuels will be successful in increasing its supplies of monazite sand ore supplies, developing U.S. separation, metals or metal/alloy capabilities at the White Mesa Mill or nearby, or otherwise fully integrating the U.S RE supply chain in the future; any expectation with regard to the future demand for rare earth materials, including any expectation that Europe will continue to accelerate vehicle electrification and other initiatives aimed at mitigating climate impacts; any expectation with regard to the economic and environmental potential presented by utilizing rare earth feedstock from monazite ore; any expectation with respect to the quantities of monazite ore to be acquired by Energy Fuels, the quantities of RE Carbonate to be produced by the White Mesa Mill or the quantities of contained TREO to be acquired by Silmet for separation; and any expectation that the rare earths produced by Energy Fuels and Neo will continue to be produced to the highest global standards of environmental protection and sustainability. Often, but not always, forward-looking information can be identified by the use of words such as “plans”, “expects”, “is expected”, “budget”, “scheduled”, “estimates”, “continues”, “forecasts”, “projects”, “predicts”, “intends”, “anticipates” or “believes”, or variations of, or the negatives of, such words and phrases, or state that certain actions, events or results “may”, “could”, “would”, “should”, “might” or “will” be taken, occur or be achieved. This information involves known and unknown risks, uncertainties and other factors that may cause actual results or events to differ materially from those anticipated in such forward-looking information. Factors that could cause actual results to differ materially from those anticipated in these forward-looking statements include risks associated with: processing difficulties and upsets; available supplies of monazite sands; the ability of the White Mesa Mill to produce RE Carbonate to meet commercial specifications on a commercial scale at acceptable costs; the ability of Silmet to separate the RE Carbonate to meet commercial specifications on a commercial scale at acceptable costs; the capital and operating costs associated with separation, metal, alloy and/or magnet production facilities; permitting and regulatory delays; litigation risks; competition from others; market factors, including future demand for and prices realized from the sale of rare earth elements; and the policies and actions of foreign governments, which could impact the competitive supply of and global markets for rare earth elements. Forward-looking statements contained herein are made as of the date of this news release, and Neo and Energy Fuels disclaim, other than as required by law, any obligation to update any forward-looking statements whether as a result of new information, results, future events, circumstances, or if management’s estimates or opinions should change, or otherwise. There can be no assurance that forward-looking statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, the reader is cautioned not to place undue reliance on forward-looking statements. Neo and Energy Fuels assume no obligation to update the information in this communication, except as otherwise required by law.

 

SOURCE Energy Fuels Inc.

For further information: ENERGY FUELS, Curtis Moore – VP of Marketing & Corporate Development, (303) 974-2154; [email protected]; NEO PERFORMANCE MATERIALS, Ali Mahdavi, SVP, Corporate Development & Capital Markets, 416-962-3300, Email: [email protected]; Jim Sims, Director, Corporate Communications, 303-503-6203, Email: [email protected], Website: www.neomaterials.com

Release – Entravision Communications Corporation Announces Closing of Acquisition of MediaDonuts

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Entravision Communications Corporation Announces Closing of Acquisition of MediaDonuts

SANTA MONICA, Calif.–(BUSINESS WIRE)– Entravision
Communications Corporation (NYSE: EVC) (“Entravision” or “the Company”) today announced the closing of the previously announced acquisition of MediaDonuts, a leading digital marketing performance and branding company with operations across seven countries in the Asia-Pacific region.

Founded in 2010 and headquartered in Singapore, MediaDonuts offers extensive digital advertising capabilities in combination with global and local media and technology firms. The company maintains strategic partnerships with some of the world’s leading technology companies and social platforms including Twitter, TikTok, Spotify, Criteo and other unique commercial alliances. MediaDonuts’ digital solution experts serve a client base of more than 500 technology and consumer brands in Thailand, Malaysia, Indonesia, India, Vietnam, Singapore and Cambodia.

“This is a great day for Entravision, and we are delighted to officially welcome MediaDonuts into the Entravision family,” said Walter Ulloa, Chairman and Chief Executive Officer of Entravision. “MediaDonuts is our second significant strategic digital acquisition in less than a year, following our very successful acquisition of a majority interest in Cisneros Interactive. Today’s acquisition of MediaDonuts continues our long-term digital and global transformation strategy that includes the United States, Latin America, Europe and Southeast Asia.”

“Our acquisition of MediaDonuts falls right in line with our goal of becoming one of the world’s leading digital marketing technology service providers,” said Juan Saldívar, Entravision’s Chief Digital, Strategy and Accountability Officer. “We have already begun collaborating with the MediaDonuts team on exciting and innovative projects and continue to expand our global footprint. I am confident that MediaDonuts’ industry expertise in the Southeast Asia region will be an important contribution to Entravision’s growth strategy and global portfolio of digital offerings.”

Entravision has significantly expanded its global reach over the past 12 months. With the Company’s entrance into Southeast Asia, Entravision now services digital customers across 33 countries. Southeast Asia has one of the fastest growing populations across the globe including 700 million people, 400 million of whom are digitally connected.

MediaDonuts’ sophisticated team of sales and media innovators totals more than 80 employees who together support their clients in programmatic buying, technology and insights and media planning. MediaDonuts also maintains a media representation arm which supports some of the largest names in media and technology through its extensive sales organization across Southeast Asia. All MediaDonuts employees are remaining with the company, and Pieter-Jan de Kroon will continue to serve as CEO out of MediaDonuts’ Singapore office.

For more information on the closing of the transaction, please review the Company’s most recent filings with the Securities and Exchange Commission on Form 8-K.

About Entravision Communications Corporation

Entravision is a diversified global media, marketing and technology company serving clients throughout the United States and in 32 countries across Latin America, Europe, and Asia. Entravision has 54 television stations and is the largest affiliate group of the Univision and UniMás television networks, and 48 Spanish-language radio stations that feature nationally recognized, award-winning talent. Our dynamic digital portfolio includes Entravision Digital, which serves SMBs in high-density U.S. Latino markets and provides cutting-edge mobile programmatic solutions and demand-side platforms that allow advertisers to execute performance campaigns using machine-learned bidding algorithms, along with Cisneros Interactive, a leader in digital advertising solutions in the Latin American and U.S. Hispanic markets representing major technology platforms, and MediaDonuts, a leader in programmatic digital solutions in Southeast Asia. Shares of Entravision Class A Common Stock trade on The New York Stock Exchange under the ticker symbol: EVC. Learn more about all of our media, marketing and technology offerings at entravision.com or connect with us on LinkedIn and Facebook.

Forward Looking Statements

This press release contains certain forward-looking statements, including without limitation the Company’s current expectations and intentions with respect to the filing of its Form 10-K. These forward-looking statements, which are included in accordance with the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, may involve known and unknown risks, uncertainties and other factors that may cause the Company’s actual results and performance in future periods to be materially different from any future results or performance suggested by the forward-looking statements in this press release. Although the Company believes the expectations reflected in such forward-looking statements are based upon reasonable assumptions, it can give no assurance that actual results will not differ materially from these expectations, and the Company disclaims any duty to update any forward-looking statements made by the Company. From time to time, these risks, uncertainties and other factors are discussed in the Company’s filings with the Securities and Exchange Commission.

 

Entravision:

Christopher T. Young

Chief Financial Officer

310-447-3870

 

Kimberly Esterkin

ADDO Investor Relations

310-829-5400

[email protected]

 

MediaDonuts:

Pieter-Jan de Kroon

Chief Executive Officer

[email protected]

 

Source: Entravision Communications Corporation

Newrange Gold (NRGOF)(NRG:CA) – Drilling Reveals Potential High-Grade Extension

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Wednesday, July 07, 2021

Newrange Gold (NRGOF)(NRG:CA)
Drilling Reveals Potential High-Grade Extension

As of April 24, 2020, Noble Capital Markets research on Newrange Gold is published under ticker symbols (NRGOF and NRG:CA). The price target is in USD and based on ticker symbol NRGOF. Research reports dated prior to April 24, 2020 may not follow these guidelines and could account for a variance in the price target.

Newrange Gold Corp is an exploration stage company focused on acquiring and exploring exploration and evaluation assets in Colombia and the United States. The Company operates in a single reportable operating segment-the acquisition, exploration, and development of mineral properties. Some of the projects acquired by the company are Pamlico gold project in Nevada and Rocky mountain project in Colorado. The company also holds an interest in the Yarumalito property, El Dovio property and Anori property in Colombia.

Mark Reichman, Senior Research Analyst of Natural Resources, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

    Follow-up drilling. Newrange Gold completed four follow-up diamond core holes representing 800.6 meters of drilling around Hole P21-115, a reverse circulation hole that discovered shallow, high-grade oxide gold mineralization 85 meters east of the Merritt Zone. All four core holes, P21-122 to 125, intersected near surface oxide mineralization resembling that seen in Hole P21-115, the Merritt Zone, and stopes on the 5428 level of the Pamlico Mine. The intercept in Hole P21-122 is lower in elevation than the 5428 level, indicating this new zone could be a down-dropped extension of high-grade mineralization in the Pamlico Mine.

    Assays results from the four follow-up holes are pending.  The four holes appear to have discovered a previously unknown extension of the historic, high-grade Pamlico Mine. Management will have a better interpretation once assay results are received and analyzed and the results will help inform future drilling …



This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary.  Proper due diligence is required before making any investment decision. 

InPlay Oil (IPOOF)(IPO:CA) – Production rates blowing through expectations

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Wednesday, July 07, 2021

InPlay Oil (IPOOF)(IPO:CA)
Production rates blowing through expectations

As of April 24, 2020, Noble Capital Markets research on InPlay Oil is published under ticker symbols (IPOOF and IPO:CA). The price target is in USD and based on ticker symbol IPOOF. Research reports dated prior to April 24, 2020 may not follow these guidelines and could account for a variance in the price target. InPlay Oil is a junior oil and gas exploration and production company with operations in Alberta focused on light oil production. The company operates long-lived, low-decline properties with drilling development and enhanced oil recovery potential as well as undeveloped lands with exploration possibilities. The common shares of InPlay trade on the Toronto Stock Exchange under the symbol IPO and the OTCQZ Exchange under the symbol IPOOF.

Michael Heim, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

    Management indicates 2021-2Q production could be 5,325 BOE/d. Such a level represents a 7% increase over 2021-1Q production and a 70% increase over 2020-2Q production. Our models assume production of 5,167 BOE/d. Management reiterated annual guidance of 5,100-5,400 BOE/d but indicated it currently expects to be at the upper end of the range and that it would reevaluate guidance when it reports 2021-2Q results on August 11th. Our models assume 5,360 BOE/d and are subject to upward revision if management raises guidance as we expect.

    The jump in production combined with higher prices is about to make cash flow explode.  Management anticipates record Adjusted Funds Flow (AFF) in 2021. InPlay reported $27 million in AFF in 2018. Surpassing that amount would blow through the $21.3 million estimate currently being indicated in our models. Management plans to use cash flow to pay down debt to a level of 1.0 times EBITDA which could …



This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary.  Proper due diligence is required before making any investment decision.