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Release – BioSig Announces Proposed Public Offering of Common Stock

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BioSig Announces Proposed Public Offering of Common Stock

News and Market Data on BioSig Technologies

Westport, CT, June 23, 2022 (GLOBE NEWSWIRE) — BioSig Technologies, Inc. (Nasdaq: BSGM) (“BioSig” or the “Company”), a medical technology company commercializing an innovative biomedical signal processing platform designed to improve signal fidelity and uncover the full range of ECG and intra-cardiac signals, today announced that it intends to offer shares of its common stock in a “best efforts” underwritten public offering. The offering is subject to market and other conditions and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

Laidlaw & Company (UK) Ltd. is acting as sole book-running manager for the offering.

BioSig intends to use the net proceeds from the offering for the continuation of commercialization activities related to the PURE EP™ System, including additional support for organizational development, to fund working capital, and for general corporate purposes and other capital expenditures.

A shelf registration statement on Form S-3 (Registration No. 333-251859) relating to the public offering of the shares of common stock described above was previously filed with the Securities and Exchange Commission (SEC) and declared effective on January 12, 2021. A preliminary prospectus supplement and accompanying prospectus relating to the underwritten public offering will be filed with the SEC and will be available on the SEC’s website at www.sec.gov. Copies of the preliminary prospectus supplement (when available) and accompanying prospectus relating to the offering may be obtained from Laidlaw & Company (UK) Ltd., 521 Fifth Ave., 12th Floor, New York, NY 10175, Attention: Syndicate Dept.; email: syndicate@laidlawltd.com.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or other jurisdiction. Any offer, if at all, will be made only by means of the prospectus supplement and accompanying prospectus forming a part of the effective registration statement.

About BioSig
Technologies

BioSig Technologies is a medical technology company commercializing a proprietary biomedical signal processing platform designed to improve signal fidelity and uncover the full range of ECG and intra-cardiac signals (www.biosig.com).

The Company’s first product, PURE EP™ System is a computerized system intended for acquiring, digitizing, amplifying, filtering, measuring and calculating, displaying, recording and storing of electrocardiographic and intracardiac signals for patients undergoing electrophysiology (EP) procedures in an EP laboratory.

Forward-looking
Statements

This press release contains “forward-looking statements.” Such statements may be preceded by the words “intends,” “may,” “will,” “plans,” “expects,” “anticipates,” “projects,” “predicts,” “estimates,” “aims,” “believes,” “hopes,” “potential” or similar words. Forward- looking statements are not guarantees of future performance, are based on certain assumptions and are subject to various known and unknown risks and uncertainties, many of which are beyond the Company’s control, and cannot be predicted or quantified and consequently, actual results may differ materially from those expressed or implied by such forward-looking statements. Such risks and uncertainties include, without limitation, risks and uncertainties associated with (i) the geographic, social and economic impact of COVID-19 on our ability to conduct our business and raise capital in the future when needed, (ii) our inability to manufacture our products and product candidates on a commercial scale on our own, or in collaboration with third parties; (iii) difficulties in obtaining financing on commercially reasonable terms; (iv) changes in the size and nature of our competition; (v) loss of one or more key executives or scientists; and (vi) difficulties in securing regulatory approval to market our products and product candidates. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Company’s filings with the Securities and Exchange Commission (SEC), including the Company’s Annual Report on Form 10-K and its Quarterly Reports on Form 10-Q. Investors and security holders are urged to read these documents free of charge on the SEC’s website at http://www.sec.gov. The Company assumes no obligation to publicly update or revise its forward-looking statements as a result of new information, future events or otherwise.


Andrew Ballou

BioSig Technologies, Inc.

Vice President, Investor Relations

55 Greens Farms Road

Westport, CT 06880

aballou@biosigtech.com

203-409-5444, x133

 

Primary Logo

Source: BioSig Technologies, Inc.

Released June 23, 2022


Release – Great Lakes Dredge & Dock Corporation Announces the Retirement of Chief Operating Officer, David E. Simonelli

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Great Lakes Dredge & Dock Corporation Announces the Retirement of Chief Operating Officer, David E. Simonelli

Research, News, and Market Data on Great Lakes Dredge & Dock

HOUSTON, June 23, 2022 (GLOBE NEWSWIRE) — Great Lakes Dredge & Dock Corporation (“Great Lakes” or the “Company”) (NASDAQ:GLDD), the largest provider of dredging services in the United States announced today that its Chief Operating Officer, David E. Simonelli, will retire effective September 16, 2022. After his retirement, he will provide consulting services to the Company.

Mr. Simonelli, who has spent forty-four years with Great Lakes, became the President of the Company’s Dredging Division in 2010, and Chief Operating Officer in 2018. His commitment to project and employee safety, environmental protection, and successful project completion has contributed significantly to the Company’s record years of profitability and project successes. In addition to his contributions to the achievements of Great Lakes, he has been recognized for his leadership, innovation, and extensive contributions to the dredging industry. The Incident & Injury Free journey Dave and former CEO Doug Mackie began in 2005 transformed the safety culture of the company and elevated the bar for safe operations for the entire US dredging industry.

Lasse Petterson, President and Chief Executive Officer commented, “Dave Simonelli’s rise through the Company’s ranks has demonstrated his dedication to Great Lakes and all of our employees. He is well known for tackling the toughest projects, the most challenging issues, and doing so with great success. One of Simonelli’s key passions has been to assure that the Bullseye culture remains a key foundation of the Company and as such, he has been a mentor and advisor to several generations of colleagues at Great Lakes who will now build on his legacy for the future. We thank him for his many years of service and know that his retirement is well deserved. We look forward to our continued association with Dave in a different capacity as we complete the transition plan which has been in progress and which will entail an operating structure that best maximizes our growth in the market and in the dredging and offshore wind industries.”

The Company
Great Lakes Dredge & Dock Corporation (“Great Lakes” or the “Company”) is the largest provider of dredging services in the United States. In addition, Great Lakes is fully engaged in expanding its core business into the rapidly developing offshore wind energy industry. The Company has a long history of performing significant international projects. The Company employs experienced civil, ocean and mechanical engineering staff in its estimating, production and project management functions. In its over 132-year history, the Company has never failed to complete a marine project. Great Lakes owns and operates the largest and most diverse fleet in the U.S. dredging industry, comprised of approximately 200 specialized vessels. Great Lakes has a disciplined training program for engineers that ensures experienced-based performance as they advance through Company operations. The Company’s Incident-and Injury-Free® (IIF®) safety management program is integrated into all aspects of the Company’s culture. The Company’s commitment to the IIF® culture promotes a work environment where employee safety is paramount.

For
further information contact:
Tina
Baginskis
Director,
Investor Relations
630-574-3024


Release – Encore Energy Announces Results Of 2022 Annual General Meeting

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Encore Energy Announces Results Of 2022 Annual General Meeting

 

ENCORE ENERGY ANNOUNCES
RESULTS OF 2022 ANNUAL GENERAL MEETING

News Release , TSX.V: EU, OTCQB:ENCUF, June 23,
2022, www.encoreuranium.com , Corpus Christi, Texas – June
23, 2022:

enCore Energy Corp. (“enCore” or the “Company”) (TSXV:EU, OTCQB:ENCUF) announced today the results from the 2022 Annual General Meeting of Shareholders held on June 22nd, 2022. A total of 92,710,149 of common shares were voted in connection with the meeting, representing approximately 28.9% of the issued and outstanding common shares of the company. Shareholders approved all motions including the re-election of directors as follows: William M. Sheriff, William B. Harris, Mark S. Pelizza, Richard M. Cherry, Dennis E. Stover, W. Paul Goranson, Nathan A. Tewalt. Shareholders also approved the appointment of auditors and the Company’s stock option plan.
 

Following the vote, the Board approved Nathan Tewalt’s resignation from the Board of Directors and approved the re-appointment of Susan Hoxie-Key as a director of the Board, all effective immediately. Mr. Tewalt will continue to serve the Company as the Chair of the Technical Advisory Committee.

 

About
enCore Energy Corp.
enCore Energy is rapidly advancing towards becoming the next producer of American uranium. With approximately 90 million pounds of U3O8
estimated in the measured and indicated categories and 9 million pounds of U3O8 estimated in the inferred category1, enCore is the most diversified in-situ recovery uranium development company in the United States. enCore is focused on becoming the next uranium producer from its licensed and past-producing South Texas Rosita Processing Plant by 2023. The South Dakota-based Dewey Burdock and Wyoming Gas Hills projects offer mid-term production opportunities with significant New Mexico uranium resource endowments providing long-term opportunities. The enCore team is led by industry experts with extensive knowledge and experience in all aspects of ISR uranium operations and the nuclear fuel cycle.
 

1 Mineral resource estimates are based on technical reports prepared in accordance with NI43-101 and available on SEDAR as well as company websites at www.encoreuranium.com.
 

For
further information please contact:
William M. Sheriff
Executive Chairman
972-333-2214

info@encoreuranium.com
www.encoreuranium.com
 

NEITHER THE TSX VENTURE EXCHANGE NOR ITS REGULATION SERVICES PROVIDER (AS THAT TERM IS DEFINED IN THE POLICIES OF THE TSX VENTURE EXCHANGE) ACCEPTS RESPONSIBILITY FOR THE ADEQUACY OR ACCURACY OF THIS RELEASE.
 

CAUTIONARY
NOTE REGARDING FORWARD-LOOKING STATEMENTS: Certain information in this news release constitutes forward-looking statements under applicable securities laws. Any statements that are contained in this news release that are not statements of historical fact may be deemed to be forward-looking statements. Forward-looking statements are often identified by terms such as “may”, “should”, “anticipate”, “expect”, “potential”, “believe”, “intend” or the negative of these terms and similar expressions. Forward-looking statements in this news release include, but are not limited to, statements relating to the intended use of the net proceeds of the Offering and the completion of any capital project or property acquisitions. Forward-looking statements necessarily involve known and unknown risks, including, without limitation, risks associated with general economic conditions; adverse industry events; future legislative and regulatory developments; inability to access additional capital; the ability of enCore to implement its business strategies; and other risks. Readers are cautioned not to place undue reliance on forward-looking statements as there can be no assurance that the plans, intentions or expectations upon which they are placed will occur. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement.

Our mailing address is:

enCore Energy Corp

101 N Shoreline Blvd Ste 450

Corpus Christi, TX 78401

Release- Element79 Gold Announces 2022 AGM Results

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Element79 Gold Announces 2022 AGM Results

Vancouver, BC / Accesswire / June 22, 2022 / Element79 Gold Corp. (CSE:ELEM) (OTC:ELMGF) (FSE:7YS) (“Element79 Gold”, or the ”
Company“) is pleased to announce the results from its Annual General Meeting (“AGM or Meeting“) held on June 22, 2022.

A requisite majority of shareholders, casting votes in person or by proxy, approved all items of business at the Meeting today. Element79 Gold would like to congratulate Konstantin Lichtenwald, Neil Pettigrew and Antonios Maragakis on their re-elections, as well as welcoming Shane Williams to the board of directors. Element79 Gold would also like to thank Julie Hajduk for her service to the Company during her tenure on the board, and wishes her success the upmost success in her future endeavours.

Adoption of the Company’s new articles (the “Articles“) and omnibus equity incentive plan (the “Plan“) as described in the Company’s information circular dated May 20, 2022 for the AGM (the “Information
Circular“), were approved by the shareholders as well together with all other matters presented to shareholders for approval including ratifying the number of, and election of directors for the financial year ended August 31, 2021, appointment of SHIM & Associates LLP, Chartered Professional Accountants, as the auditors of the Company for the financial years ending in August 31, 2021 and August 31, 2022, and authorizing the rectification of certain corporate deficiencies. Biographies for the board, a copy of the Articles, and a copy of the Plan are included in the Information Circular, a copy of which was filed on SEDAR on June 1, 2022 and on the Company’s website.

The AGM took place at the offices of Clark Wilson LLP at 900 – 885 West Georgia Street, Vancouver, BC on Wednesday, June 22, 2022 at 10:00 A.M. PDT. The Company will conducted a successful hybrid meeting that allowed registered shareholders and duly appointed proxyholders to participate both online and in person. The Company offered a virtual format in order to provide shareholders with an equal opportunity to attend and participate at the AGM, regardless of the particular constraints, circumstances or risks that they may be facing as a result of COVID-19.

 

Contact Information
For corporate matters, please contact:
James C. Tworek, Chief Executive Officer
E-mail: jt@element79gold.com  

 

For investor relations inquiries, please contact:
Investor Relations Department
Phone: +1 (604) 200-3608
E-mail: investors@element79gold.com
 

About Element79 Gold

Element79 Gold is a mining company focused on the acquisition, exploration and development of mining properties for gold and associated metals. Element79 Gold has acquired its flagship Maverick Springs Project (“Maverick Springs”) between the Elko and White Pine Counties in Nevada, USA and recently completed an 43-101-compliant, pit-constrained mineral resource estimate (MRE) on the flagship Maverick Springs project located in the famous gold mining district of northeastern Nevada. The acquisition of Maverick Springs also included a portfolio of 15 properties along the Battle Mountain trend in Nevada and is completing analysis on these properties for further merit of exploration, along with the potential for sale or spin-out. The Company has recently acquired two previously-producing high-grade Au-Ag mines in Peru. The Company’s management, exploration and operations teams have completed their due diligence trip to Peru to review these assets and establish its in-country Operations team. The intent of this asset purchase is to bring on production and generate cash flow from these assets within 24 months from their acquisition, anticipated in June 2022. In British Columbia, the Company has executed a Letter of Intent to acquire a private company which holds the option to 100% interest of the Snowbird High-Grade Gold Project, which consists of 10 mineral claims located in Central British Columbia, approximately 20km west of Fort St. James. The Company also has an option to acquire 100% interest in the Dale Property which consists of 90 unpatented mining claims located approximately 100 km southwest of Timmins, Ontario, Canada in the Timmins Mining Division, Dale Township.

Cautionary Note Regarding Forward Looking Statements

This press contains “forward?looking information” and “forward-looking statements” under applicable securities laws (collectively, “forward?looking statements”). These statements relate to future events or the Company’s future performance, business prospects or opportunities that are based on forecasts of future results, estimates of amounts not yet determinable and assumptions of management made in light of management’s experience and perception of historical trends, current conditions and expected future developments. Forward-looking statements include, but are not limited to, statements with respect to: the proposed acquisition of certain properties and the timing for completion of such transactions; the Company’s business strategy; future planning processes; exploration activities; the timing and result of exploration activities; capital projects and exploration activities and the possible results thereof; acquisition opportunities; and the impact of acquisitions, if any, on the Company. Assumptions may prove to be incorrect and actual results may differ materially from those anticipated. Consequently, forward-looking statements cannot be guaranteed. As such, investors are cautioned not to place undue reliance upon forward-looking statements as there can be no assurance that the plans, assumptions or expectations upon which they are placed will occur. All statements other than statements of historical fact may be forward?looking statements. Any statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, objectives or future events or performance (often, but not always, using words or phrases such as “seek”, “anticipate”, “plan”, “continue”, “estimate”, “expect”, “may”, “will”, “project”, “predict”, “forecast”, “potential”, “target”, “intend”, “could”, “might”, “should”, “believe” and similar expressions) are not statements of historical fact and may be “forward?looking statements”.

Actual results may vary from forward-looking statements. Forward-looking statements are subject to known and unknown risks, uncertainties and other factors that may cause actual results to materially differ from those expressed or implied by such forward-looking statements, including but not limited to: that the parties may not be able to satisfy the conditions to Closing of the Acquisition, at all or on the terms announced; the duration and effects of the coronavirus and COVID-19; risks related to the integration of acquisitions; actual results of exploration activities; conclusions of economic evaluations; changes in project parameters as plans continue to be refined; commodity prices; variations in ore reserves, grade or recovery rates; actual performance of plant, equipment or processes relative to specifications and expectations; accidents; labour relations; relations with local communities; changes in national or local governments; changes in applicable legislation or application thereof; delays in obtaining approvals or financing or in the completion of development or construction activities; exchange rate fluctuations; requirements for additional capital; government regulation; environmental risks; reclamation expenses; outcomes of pending litigation; limitations on insurance coverage as well as those factors discussed in the Company’s other public disclosure documents, available on www.sedar.com. Although the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements, there may be other factors that cause results not to be as anticipated, estimated or intended. The Company believes that the expectations reflected in these forward?looking statements are reasonable, but no assurance can be given that these expectations will prove to be correct and such forward?looking statements included herein should not be unduly relied upon. These statements speak only as of the date hereof. The Company does not intend, and does not assume any obligation, to update these forward-looking statements, except as required by applicable laws.

Neither
the Canadian Securities Exchange nor the Market Regulator (as that term
is defined in the policies of the Canadian Securities Exchange) accepts
responsibility for the adequacy or accuracy of this release.

SOURCE: Element79 Gold Corp.

View source version on accesswire.com:
https://www.accesswire.com/706233/Element79-Gold-Announces-2022-AGM-Results

Copyright
© 2022 Element79 Gold Corp, All rights reserved.
You are receiving this email because you subscribed to received updates from Element 79 Gold on our website www.element79.gold

 

.

Engine Gaming and Media (GAME) – Light At The End Of The Tunnel

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Thursday, June 23, 2022

Engine Gaming and Media (GAME)
Light At The End Of The Tunnel

Engine Gaming and Media, Inc. (NASDAQ:GAME) (TSX-V:GAME) provides premium social sports and esports gaming experiences, as well as unparalleled data analytics, marketing, advertising, and intellectual property to support its owned and operated direct-to-consumer properties, while also providing these services to enable its clients and partners. The company’s subsidiaries include Stream Hatchet, the global leader in gaming video distribution analytics; Sideqik, a social influencer marketing discovery, analytics, and activation platform; WinView Games, a social predictive play-along gaming platform for viewers to play while watching live events; and Frankly Media, a digital publishing platform used to create, distribute and monetize content across all digital channels. Engine Media generates revenue through a combination of direct-to-consumer fees, streaming technology and data SaaS-based offerings, and programmatic advertising. For more information, please visit www.enginegaming.com.

Michael Kupinski, Director of Research, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Exits UMG. The company announced that it has sold its UMG subsidiary to Harena Data, Inc. in an asset purchase. Purchase price was not disclosed, but we expect it to be diminutive. We view the sale favorably as the company exits this money losing operation and as the company positions itself to swing toward break even and concentrates on its profitable growth oriented businesses. 

Strategy gains visibility. The recent moves shift the company away from direct-to-consumer platforms in order to focus on its B2B businesses that carry higher margins. The repositioning of the company is expected to swing the company toward run rate break cash flow by the second half fiscal 2023….

This Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision. 

Voyager Digital (VYGVF) – Caught Up in the Three Arrows Vortex; Lowering to Market Perform

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Thursday, June 23, 2022

Voyager Digital (VYGVF)
Caught Up in the Three Arrows Vortex; Lowering to Market Perform

Voyager Digital Ltd.’s (TSX: VOYG) (OTCQX: VYGVF) (FRA: UCD2) US subsidiary, Voyager Digital, LLC, is a fast-growing cryptocurrency platform in the United States founded in 2018 to bring choice, transparency, and cost-efficiency to the marketplace. Voyager offers a secure way to trade over 100 different crypto assets using its easy-to-use mobile application. Through its subsidiary Coinify ApS, Voyager provides crypto payment solutions for both consumers and merchants around the globe. To learn more about the company, please visit https://www.investvoyager.com.

Joe Gomes, Senior Research Analyst, Noble Capital Markets, Inc.

Joshua Zoepfel, Research Associate, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Three Arrows Capital. Voyager is caught up in the Three Arrows collapse. According to press reports, Three Arrows Capital is facing a liquidity crisis due to the collapse of the crypto market. It’s believed that the firm could be facing bankruptcy as it struggles to pay off its debts. Yesterday, Voyager announced it may issue a notice of default to Three Arrows Capital for failure to repay its loan, which consists of 15,250 Bitcoin, roughly $305 million at the current price, and $350 million of USDC.

Voyager Response. Voyager has requested payment in full by June 27th. Voyager intends to pursue recovery from 3AC and is in discussions with the Company’s advisors regarding the legal remedies available. The Company is unable to assess at this point the amount it will be able to recover from 3AC….

This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision. 

Motorsport Games (MSGM) – Key Factors Investors Are Missing

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Thursday, June 23, 2022

Motorsport Games (MSGM)
Key Factors Investors Are Missing

Motorsport Games, a Motorsport Network company, combines innovative and engaging video games with exciting esports competitions and content for racing fans and gamers around the globe. The Company is the officially licensed video game developer and publisher for iconic motorsport racing series across PC, PlayStation, Xbox, Nintendo Switch and mobile, including NASCAR, INDYCAR, 24 Hours of Le Mans and the British Touring Car Championship (“BTCC”). Motorsport Games is an award-winning esports partner of choice for 24 Hours of Le Mans, Formula E, BTCC, the FIA World Rallycross Championship and the eNASCAR Heat Pro League, among others.

Michael Kupinski, Director of Research, Noble Capital Markets, Inc.

Patrick McCann, Research Associate, Noble Capital Markets, Inc.

Refer to the full report for the price target, fundamental analysis, and rating.

Non-deal roadshow highlights. Last week, Dmitry Kozko, CEO, hosted meetings for investors in the Midwest. Key highlights include the company’s product roadmap, exclusive world-class licenses, and insights into its financial flexibility in bringing its products to market.

Long runway. The company’s exclusive racing game licenses last up to 10 years. This allows the company a favorably runway to develop and bring to market its games across all its franchises. The company has not changed its product launch roadmap, but could should market conditions warrant.

…

This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst certification and important disclosures included in the full report. NOTE: investment decisions should not be based upon the content of this research summary. Proper due diligence is required before making any investment decision. 

Improving Drug Formulations for Maximum Efficacy

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Image Credit: Pixabay (Pexels)


How Do Drugs Know Where To Go In The Body? Why Some Medications Are Swallowed While Others Are Injected

When you take aspirin for a headache, how does the aspirin know to travel to your head and alleviate the pain?

The short answer is, it doesn’t: Molecules can’t transport themselves through the body, and they don’t have control over where they eventually end up. But researchers can chemically modify drug molecules to make sure that they bind strongly to the places we want them and weakly to the places we don’t.

Pharmaceutical products contain more than just the active drug that directly affects the body. Medications also include “inactive ingredients,” or molecules that enhance the stability, absorption, flavor and other qualities that are critical to allowing the drug to do its job. For example, the aspirin you swallow also has ingredients that both prevent the tablet from fracturing during shipping and help it break apart in your body.

This article was republished with permission from The Conversation, a news site dedicated to sharing ideas from academic experts. It was written by and represents the research-based opinions of Tom Anchordoquy, Professor of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus.

As a pharmaceutical scientist, I’ve been studying drug delivery for the past 30 years. That is, developing methods and designing nondrug components that help get a medication where it needs to go in the body. To better understand the thought process behind how different drugs are designed, let’s follow a drug from when it first enters the body to where it eventually ends up.

 

How Drugs
are Absorbed in the Body

When you swallow a tablet, it will initially dissolve in your stomach and intestines before the drug molecules are absorbed into your bloodstream. Once in the blood, it can circulate throughout the body to access different organs and tissues.

Drug molecules affect the body by binding to different receptors on cells that can trigger a particular response. Even though drugs are designed to target specific receptors to produce a desired effect, it is impossible to keep them from continuing to circulate in the blood and binding to nontarget sites that potentially cause unwanted side effects.


Image Credit: Jorgen Schyberg (Flickr)

Drug molecules circulating in the blood also degrade over time and eventually leave the body in your urine. A classic example is the strong smell your urine might have after you eat asparagus because of how quickly your kidney clears asparagusic acid. Similarly, multivitamins typically contain riboflavin, or vitamin B2, which causes your urine to turn bright yellow when it is cleared. Because how efficiently drug molecules can cross the intestinal lining can vary depending on the drug’s chemical properties, some of the drugs you swallow never get absorbed and are removed in your feces.

Because not all of the drug is absorbed, this is why some medications, like those used to treat high blood pressure and allergies, are taken repeatedly to replace eliminated drug molecules and maintain a high enough level of drug in the blood to sustain its effects on the body.

 

Getting Drugs
to the Right Place

Compared with pills and tablets, a more efficient way of getting drug into the blood is to inject it directly into a vein. This way, all the drug gets circulated throughout the body and avoids degradation in the stomach.

Many drugs that are given intravenously are “biologics” or “biotechnology drugs,” which include substances derived from other organisms. The most common of these are a type of cancer drug called monoclonal antibodies, proteins that bind to and kill tumor cells. These drugs are injected directly into a vein because your stomach can’t tell the difference between digesting a therapeutic protein and digesting the proteins in a cheeseburger.

In other cases, drugs that need very high concentrations to be effective, such as antibiotics for severe infections, can be delivered only through infusion. While increasing drug concentration can help make sure enough molecules are binding to the correct sites to have a therapeutic effect, it also increases binding to nontarget sites and the risk of side effects.

One way to get a high drug concentration in the right location is to apply the drug right where it’s needed, like rubbing an ointment onto a skin rash or using eyedrops for allergies. While some drug molecules will eventually get absorbed into the bloodstream, they will be diluted enough that the amount of drug that reaches other sites is very low and unlikely to cause side effects. Similarly, an inhaler delivers the drug directly to the lungs and avoids affecting the rest of the body.

 

Patient Compliance

Finally, a key aspect in all drug design is to simply get patients to take medications in the right amounts at the right time.

Because remembering to take a drug several times a day is difficult for many people, researchers try to design drug formulations so they need to be taken only once a day or less.

Similarly, pills, inhalers or nasal sprays are more convenient than an infusion that requires traveling to a clinic for a trained clinician to inject it into your arm. The less troublesome and expensive it is to administer a drug, the more likely it is that patients will take their medication when they need it. However, sometimes infusions or injections are the only effective way that certain drugs can be administered.

Even with all the science that goes into understanding a disease well enough to develop an effective drug, it is often up to the patient to make it all work as designed.


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Release – Chakana Closes Second Tranche Of Private Placement And Provides Update

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Chakana Closes Second Tranche Of Private Placement And Provides Update

Research, News, and Market Data on Chakana Copper

Vancouver, B.C., June 22, 2022
– Chakana Copper Corp. (TSX-V: PERU; OTCQB: CHKKF; FWB: 1ZX) (the “Company” or “Chakana”) is pleased to announce that it has completed a second and final tranche of its previously announced private placement (the “Private
Placement”) for 10,470,451 units of the Company (“Units”) at a price of C$0.11 per Unit for gross proceeds of C$1,151,749.  Combined with the first tranche that closed in May (see news release dated May 24, 2022), the financing resulted in total gross proceeds of $6,241,353.

Each Unit consists of one common share in the capital of the Company (each, a “Share”) and one-half of one common share purchase warrant (each whole warrant, a “Warrant”).  Each Warrant entitles the holder to purchase one additional Share at a price of $0.20 per Share for a period of two years from closing of the Private Placement. The Company may accelerate the expiry of the Warrants in the event that for any ten consecutive trading days the closing price of the Shares is greater than $0.30.

David Kelley, President and CEO commented, “We are excited to be fully financed as we execute an aggressive exploration drilling campaign that began June 15, 2022. This is a bold step-out exploration program applying what we have learned in the last 4 years and utilizing the expertise and support from the Gold Fields exploration team. We have updated our target ranking criteria to include the potential to discover larger tonnage deposits. In addition to high-grade mineralization hosted in tourmaline breccia pipes, we will also be testing targets related to the potential coalescence of breccia pipes (mega-breccias), epithermal mineralization in zones of pervasive argillic alteration, and mineralization related to a rhyodacite dome. We believe these mineralization styles are all part of the same Soledad mineral system that occupies a 12 km2 footprint.”

The Company intends to use the net proceeds of the Private Placement for exploration and development of the Company’s high-grade copper-gold-silver discovery at the Soledad Project, located in the Ancash region of Peru, and for ESG programs, general working capital and administrative purposes. On January 11, 2022, the Company announced aninitial inferred resource hosting
191,000 ounces of gold, 11.7 million ounces of silver, and 130 million pounds
of copper in seven tourmaline breccia pipes.

Chakana paid aggregate finder’s fees of C$56,511 and issued 513,736 finder’s warrants (the “Finder’s
Warrants”) in connection with the second tranche of the Private Placement.  Each Finder’s Warrant is exercisable to purchase one Share at a price of $0.20 per Share for a period of two years from closing of the Private Placement.

All securities issued under the Private Placement are subject to a four-month hold period expiring on October 22, 2022 in accordance with applicable Canadian securities laws, in addition to such other restrictions as may apply under applicable securities laws in jurisdictions outside of Canada. Final closing of the Private Placement is subject to all necessary regulatory approvals, including the approval of the TSX Venture Exchange.

The common shares have not been registered under the United States Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements. This news release does not constitute an offer to sell or a solicitation of an offer to buy such securities in any jurisdiction in which such an offer or sale would be unlawful.

Corporate
Update

Pursuant to the extension agreement and revised payment terms for the Company’s purchase option agreement with Condor Resources, the Company has elected to proceed with the second option which requires cash and share payments to be made over a three-year period, as described in more detail in the Company’s news release dated April 18, 2022. Accordingly, the Company will pay Condor US$800,000 and issue 1,379,310 shares prior to June 23, 2022.

Exploration
Update

The company initiated a step-out exploration drilling campaign on June 15, 2022 to test thirteen new targets not previously drilled on the north side of the project. The campaign is initially planned with one drill rig for approximately 3,000m of core drilling with one or two holes in each target. Once these targets have been drilled, a decision will be made regarding both additional target testing and follow-up drilling. These thirteen targets were selected from a total of 154 targets identified on the project that were prioritized during an in-house technical workshop incorporating recently acquired Offset IP survey results. The principal target areas for this round of drilling on the north side of the project are 1) Cima Blanca (in-progress), 2) Bx 4 cluster, 3) Faro, 4) Western Breccias, 5) Paloma Trend, and 6) Paloma-Huancarama megabreccia target (Figure 1). Numerous additional high priority targets exist on the south side of the project that will be drill tested once a drill permit is awarded for this area.

About
Chakana Copper Corp

Chakana Copper Corp is a Canadian-based minerals exploration company that is currently advancing the Soledad Project located in the Ancash region of Peru, a highly favorable mining jurisdiction with supportive communities. The Soledad Project is notable for the high-grade copper-gold-silver mineralization that is hosted in tourmaline breccia pipes. An initial inferred resource estimate for seven breccia pipes was announced in Q1 2022 (see news release dated February 23, 2022), with 6.73 Mt containing 191,000 ounces of gold, 11.7 million ounces of silver, and 130 million pounds of copper. In addition, extensive multidisciplinary exploration has defined 154 exploration targets, 18 of which have been tested to date (12%), confirming that Soledad is a large, well-endowed mineral system with strong exploration upside.  Chakana’s investors are uniquely positioned as the Soledad Project provides exposure to copper and precious metals. For more information on the Soledad project, please visit the website at www.chakanacopper.com.

Results of an initial resource estimate and additional information concerning the Project, including a technical report prepared in accordance with National Instrument 43-101, are available on Chakana’s profile at www.sedar.com.

ON
BEHALF OF THE BOARD

(signed) “David Kelley”
David Kelley
President and CEO

For further information contact:
Joanne Jobin, Investor Relations Officer
Phone: 647 964 0292
Email: 
jjobin@chakanacopper.com

Neither
TSX Venture Exchange nor its Regulation Services Provider (as that term is
defined in the policies of the Exchange) accepts responsibility for the
adequacy or accuracy of this release.

Forward-looking
Statement Advisory: This release contains forward-looking statements, including
statements relating to the use of proceeds and completion of the Private
Placement. Forward-looking statements involve known and unknown risks, uncertainties,
and other factors which may cause the actual results, performance, or
achievements of Chakana to be materially different from any future results,
performance, or achievements expressed or implied by the forward-looking
statements. Forward looking statements or information relates to, among other
things, the interpretation of the nature of the mineralization at the Soledad copper-gold-silver project (the “Project”), the
potential to expand the mineralization, and to develop and grow a resource
within the Project, the planning for further exploration work,
the ability to de-risk the potential exploration targets, and our belief in the
potential for mineralization within unexplored parts of the Project.
These forward-looking statements are based on management’s current expectations
and beliefs but given the uncertainties, assumptions and risks, readers are
cautioned not to place undue reliance on such forward- looking statements or
information. The Company disclaims any obligation to update, or to publicly
announce, any such statements, events or developments except as required by
law.

Figure 1 – Map showing total defined targets for the Soledad project by type. Principal target clusters on the north side of the project being tested in the current exploration drilling program are Cima Blanca, Bx 4, Faro, Western Breccias, Paloma-Huancarama trends. Target clusters on the south side will be drill tested once the drill permit is approved for this area.   


Release – Engine Gaming & Media Announces Agreement to Divest Assets of UMG Gaming Subsidiary to Harena Data

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Engine Gaming & Media Announces Agreement to Divest Assets of UMG Gaming Subsidiary to Harena Data

Research, News, and Market Data on Engine Gaming & Media

NEW YORK, NY / ACCESSWIRE / June 22, 2022 / Engine Gaming and Media, Inc. (“Engine” or the “Company”) (NASDAQ:GAME) (TSX-V:GAME), a data-driven, gaming, media and social influencer marketing solutions company, today announced that its wholly owned subsidiary, UMG Events, LLC (“UMG”), had entered into an agreement with Harena Data, Inc. (“Harena Data”) for the sale of certain UMG assets. In addition to the transfer of assets, UMG will supply various technology services to Harena Data following the closing of the transaction. The transaction is subject to customary closing conditions, including regulatory approvals, and is expected to close in the Company’s fiscal fourth quarter.

Harena Data will take ownership of the UMG online business, which hosts daily tournaments and matches for competitive esports players, as well as the ownership of the studio and media properties under UMG including its social channels. This transaction marks the next step in the Company’s ongoing portfolio shaping strategy to sharpen the focus on its core businesses and drive enhanced value creation. Harena Data Inc has focused on the building of gaming ecosystems and business units to serve those ecosystems.

“Earlier this year, we began a comprehensive portfolio review to identify cost savings opportunities available to Engine that would best position our Company for continued sustainable growth while focusing on our core businesses,” commented Lou Schwartz, Chief Executive Officer of Engine. “The transition of UMG will further reduce cash expenditure by approximately $16M on a year-over-year basis and enable us to utilize our capital more efficiently. This is part of an overall effort to relieve the Company of the more significant cash expenditures necessary to support B2C gaming businesses, particularly as we enter a far more difficult macroeconomic environment. With this transaction, the sale of Eden games, and other cost savings initiatives we have implemented or will implement in the near term, we position the Company to achieve its goal of run rate breakeven in 2023.”

Tom Rogers, Executive Chairman of Engine, added, “We continue to take meaningful action to focus the business more narrowly on our B2B analytics, marketing, advertising and gaming businesses and sharpen our attention on our core growth engines while unlocking value for our shareholders. Beyond the benefits to our shareholders, this transaction will ensure the Engine team can focus on continuing to execute on our long-term strategy by positioning our assets to capitalize on numerous macro sector growth trends within the advertising and marketing landscape with particular focus on the fast growing social influencer space.”

Mr. Rogers concluded, “Engine will maintain close partnerships with many of UMG’s existing and historical clients, most notably Microsoft, Electronic Arts, and Riot Games through relationships with our other subsidiaries. We want to especially thank the terrific team at UMG for their great work building a high-quality next-generation gaming experience.”

About
Engine Gaming and Media, Inc.

Engine Gaming and Media, Inc. (NASDAQ:GAME) (TSX-V:GAME) provides premium social sports and esports gaming experiences, as well as unparalleled data analytics, marketing, advertising, and intellectual property to support its owned and operated direct-to-consumer properties, while also providing these services to enable its clients and partners. The company’s subsidiaries include Stream Hatchet, the global leader in gaming video distribution analytics; Sideqik, a social influencer marketing discovery, analytics, and activation platform; WinView Games, a social predictive play-along gaming platform for viewers to play while watching live events; and Frankly Media, a digital publishing platform used to create, distribute and monetize content across all digital channels. Engine Media generates revenue through a combination of direct-to-consumer fees, streaming technology and data SaaS-based offerings, and programmatic advertising. For more information, please visit www.enginegaming.com.

About
Harena Data Inc.

Founded in 2017, Harena Data has developed software for league development, launched streaming channels and have worked closely with educational and community organizations to develop the gaming ecosystem. Harena Data Inc is also the founder of “The Esports Combine”, the largest aggregator of esports scholarships on the planet. The principles of Harena Data have a strong background in esports, event management, motion picture production, and telecommunications. In addition to GYO Score, Harena Data specializes in esports consultation regarding the development and deployment of esports venues, scholastic esports programs, and esports league concepts. For more information, please visit www.harenadata.net.

Cautionary
Statement on Forward-Looking Information

This news release contains forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of Engine to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Often, but not always, forward-looking statements can be identified by the use of words such as “plans”, “expects” or “does not expect”, “is expected”, “estimates”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved. In respect of the forward-looking information contained herein, Engine has provided such statements and information in reliance on certain assumptions that management believed to be reasonable at the time. Forward-looking information involves known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements stated herein to be materially different from any future results, performance or achievements expressed or implied by the forward-looking information. Actual results could differ materially from those currently anticipated due to a number of factors and risks. Accordingly, readers should not place undue reliance on forward-looking information contained in this news release.

The forward-looking statements contained in this news release are made as of the date of this release and, accordingly, are subject to change after such date. Engine does not assume any obligation to update or revise any forward-looking statements, whether written or oral, that may be made from time to time by us or on our behalf, except as required by applicable law.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Investor
Relations Contact:

Shannon Devine

MZ North America
Main: 203-741-8811
GAME@mzgroup.us

SOURCE: Engine Gaming and Media, Inc.


Lowe’s Expands into the Metaverse and Sees Endless Possibilities

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Image Credit: Zee (Flickr)


With Free Downloads of Metaverse Assets, Lowe’s now Helps with Projects in the Real and Augmented Worlds

While the metaverse now includes fast-food chains like Wendy’ (WEN), McDonald’s (MCD), and Chipotle (CMG) that have positioned themselves on augmented reality platforms for branding, a newcomer, Lowe’s (LOW), the home improvement store, has bigger goals. Lowe’s announced yesterday (June 21) in a press release that customers will be able to enter the metaverse and use augmented reality to help them visualize a project they are involved in. The initial launch will include free downloads of products for added home design inspiration.

In the release announcing the additional service, Lowe’s says they have been at the forefront of building in the real world for more than 100 years, and now they will be helping builders of the metaverse create new possibilities. Rather than entering the metaverse with a storefront to sell virtual goods, Lowe’s aims to equip builders (at no cost) with items from its real-world shelves to give their creations more eye appeal.

To get them started, Lowe’s has made more than 500 3D metaverse products available for download for free using Lowe’s Open Builder. Open builder is a new asset hub designed to be available to all creators.

“We’ve been at the forefront of building since our beginning, and the metaverse is in a pivotal stage of development. It’s only natural that we would be interested in working alongside and in service of the emerging community of builders creating this new world, with the democratization of possibility in mind,” said Marisa Thalberg, Lowe’s chief brand and marketing officer. “At the same time, we are also very clear on our reason for being – to make homes better for all by helping our customers to create real-world value in their homes, in their jobs and in their communities. This will continue to be our North Star in the metaverse.”


Image: Lowe’s pioneered virtual reality training within its stores with Holoroom

Lowe’s says its vision is for both virtual and augmented worlds to play a role in its customers’ lives. While this is the company’s first step into the metaverse, Lowe’s has been using emerging technology to help customers gain inspiration and more easily visualize and plan their home improvement projects. The recently launched Measure Your Space, uses LiDAR to sense depth and map dimensions of a space, and Holoroom How To, was one of the first home improvement virtual reality clinics. It teaches customers skills like how to tile a shower and does it in a fully immersive virtual environment.

“Over the past several years, we have infused new technologies into the planning and shopping experience and know our customers have benefitted greatly from being able to explore and test home improvement projects in the virtual world before taking the leap to implementation in their real-world homes or job sites,” said Seemantini Godbole, chief information officer of Lowe’s. “By entering the metaverse now, we can explore new opportunities to serve, enable and inspire our customers in a way no other home improvement retailer today is doing.”

The 500 starter assets available include items such as lighting, patio furniture, area rugs, kitchen, and bath accessories, they will be usable across metaverse and non-metaverse environments, such as gaming, augmented reality, and creative design. It is expected that these assets will be adopted by metaverse builders making virtual land, homes, goods, and experiences for use in other decentralized communities. These will even include custom, wearable NFTs.

Lowe’s stock price saw little or no impact from the announcement.

Paul Hoffman

Managing Editor, Channelchek

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Sources

www.LowesOpenBuilder.com

https://www.lowesinnovationlabs.com/

https://www.prnewswire.com/news-releases/lowes-to-help-builders-create-a-new-world-of-possibility-inside-the-metaverse-301571465.html

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C-Suite Interview with Great Lakes Dredge & Dock (GLDD) President & CEO Lasse Petterson and SVP, US Offshore Wind Eleni Beyko

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Noble Capital Markets Senior Research Analyst Joe Gomes sits down with Great Lakes Dredge & Dock (GLDD) President & CEO Lasse Petterson and SVP, US Offshore Wind Eleni Beyko

Research, News, and Advanced Market Data on GLDD


View all C-Suite Interviews


The 2022 C-Suite Interview series is now available on major podcast platforms

About Great Lakes

Great Lakes Dredge & Dock Corporation is the largest provider of dredging services in the United States. In addition, Great Lakes is fully engaged in expanding its core business into the rapidly developing offshore wind energy industry. The Company has a long history of performing significant international projects. The Company employs experienced civil, ocean and mechanical engineering staff in its estimating, production and project management functions. In its over 132-year history, the Company has never failed to complete a marine project. Great Lakes owns and operates the largest and most diverse fleet in the U.S. dredging industry, comprised of approximately 200 specialized vessels. Great Lakes has a disciplined training program for engineers that ensures experienced-based performance as they advance through Company operations. The Company’s Incident-and Injury-Free® (IIF®) safety management program is integrated into all aspects of the Company’s culture. The Company’s commitment to the IIF® culture promotes a work environment where employee safety is paramount.

Release – BioSig Announces New Evaluation Agreement for its PURE EP System with Cleveland Clinic

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BioSig Announces New Evaluation Agreement for its PURE EP System with Cleveland Clinic

News and Market Data on BioSig Technologies

Leading Center of Excellence will participate in a 60-day
evaluation of The Company’s signal processing technology

Westport, CT, June 22, 2022 (GLOBE NEWSWIRE) — BioSig Technologies, Inc. (NASDAQ: BSGM) (“BioSig” or the “Company”) a medical technology company advancing electrophysiology workflow by delivering greater intracardiac signal fidelity through its proprietary signal processing platform, today announced it has entered an evaluation agreement for its PURE EP(TM) System with the Cleveland Clinic.

The evaluation agreement marks the first since BioSig inducted a new commercialization team. Consistent with The Company’s stated national rollout strategy, Cleveland Clinic will participate in a 60-day evaluation of BioSig’s PURE EP(TM) System. The Company recently announced that is has restructured its clinical support and installation teams to streamline and accelerate the pathway from product evaluation to adoption.

“We are excited to include Cleveland Clinic as an evaluation center for the Pure EP System. We look forward to working alongside their physicians to demonstrate the superior signal quality that can be achieved on even the most difficult arrhythmias,” commented Gray Fleming, Chief Commercialization Officer, BioSig Technologies, Inc. 

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. U.S. News & World Report consistently names Cleveland Clinic as one of the nation’s best hospitals in its annual “America’s Best Hospitals” survey. As a leader in arrhythmia treatment and diagnosis, Cleveland Clinic medical centers include state-of-the-art electrophysiology laboratories, world-class physicians and researchers, and the latest cutting-edge technologies and protocols deployed for the treatment of heart abnornmalities. To learn more, visit clevelandclinic.org. 

 

To date, over 75 physicians have completed over 2500 patient cases with the PURE EP(TM) System. The Company is in a national commercial launch of the PURE EP(TM) System. The technology is in regular use in some of the country’s leading centers of excellence, including Mayo Clinic, and Texas Cardiac Arrhythmia Institute at St. David’s Medical Center.

Clinical data acquired by the PURE EP(TM) System in a multi-center study at centers of excellence including Texas Cardiac Arrhythmia Institute at St. David’s Medical Center  was recently published in the Journal of Cardiovascular Electrophysiology and is available electronically with open access via the Wiley
Online Library. Study results showed 93% consensus across the blinded reviewers with a 75% overall improvement in intracardiac signal quality and confidence in interpreting PURE EP(TM) signals over conventional sources.

 

About
BioSig Technologies

BioSig Technologies is a medical technology company commercializing a proprietary biomedical signal processing platform designed to improve signal fidelity and uncover the full range of ECG and intra-cardiac signals (www.biosig.com).

The Company’s first product, PURE EP(TM) System, is a novel signal processing and acquisition platform designed to extract advanced diagnostic and therapeutic data that enhances physician workflow and increases throughput. PURE EP(TM) was engineered to address the limitations of existing EP technologies by empowering physicians with superior signals and actionable insights.

 

Forward-looking
Statements

 This press release contains “forward-looking statements.” Such statements may be preceded by the words “intends,” “may,” “will,” “plans,” “expects,” “anticipates,” “projects,” “predicts,” “estimates,” “aims,” “believes,” “hopes,” “potential” or similar words. Forward-looking statements are not guarantees of future performance, are based on certain assumptions, and are subject to various known and unknown risks and uncertainties, many of which are beyond the Company’s control and cannot be predicted or quantified, and consequently, actual results may differ materially from those expressed or implied by such forward-looking statements. Such risks and uncertainties include, without limitation, risks and uncertainties associated with (i) the geographic, social, and economic impact of COVID-19 on our ability to conduct our business and raise capital in the future when needed, (ii) our inability to manufacture our products and product candidates on a commercial scale on our own, or in collaboration with third parties; (iii) difficulties in obtaining financing on commercially reasonable terms; (iv) changes in the size and nature of our competition; (v) loss of one or more key executives or scientists; and (vi) difficulties in securing regulatory approval to market our products and product candidates. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Company’s filings with the Securities and Exchange Commission (SEC), including the Company’s Annual Report on Form 10-K and its Quarterly Reports on Form 10-Q. Investors and security holders are urged to read these documents free of charge on the SEC’s website at http://www.sec.gov. The Company assumes no obligation to publicly update or revise its forward-looking statements as a result of new information, future events, or otherwise.


Andrew Ballou
BioSig Technologies, Inc.
Vice President, Investor Relations
55 Greens Farms
Westport, CT 06880
aballou@biosigtech.com
203-409-5444, x133
 

Primary Logo

Source: BioSig Technologies, Inc.

Released
June 22, 2022