NNW News – Genprex Inc. (GNPX) Making Headway in Clinical Program Expansion, Company Growth

Genprex Inc. (GNPX) Making Headway in Clinical Program Expansion, Company Growth


Related Editorial
Biotech and biopharma industry leaders are posting record financials and hitting milestone markers in their research and growth, good indicators of a strong market with potential for robust returns on investment.

Genprex Inc. (NASDAQ: GNPX) (GNPX Profile) has completed key steps in its overall strategy to expand its clinical development programs and bring Oncoprex(TM) immunogene therapy, its lead drug candidate, to commercialization. Over the past five years, Amgen Inc. (NASDAQ: AMGN) has invested nearly $19 billion in R&D and, as a result, is now advancing a record number of clinical assets. Biogen Inc. (NASDAQ: BIIB) has added four new programs to its pipeline this quarter alone as the company continues to diversify and build depth within neuroscience and pursue therapeutic adjacencies. Celgene Corporation (NASDAQ: CELG) announced recently that its stockholders voted to approve the company’s proposed combination with Bristol-Myers Squibb Company (NYSE: BMY). This key milestone brings the two complementary biopharmaceutical companies one step closer to combining their efforts on a shared mission of discovering, developing and delivering innovative medicines for patients with serious diseases.

To view the full editorial, visit http://nnw.fm/jfD6C

About Genprex, Inc.

Genprex, Inc. is a clinical stage gene therapy company developing potentially life-changing technologies for cancer patients, based upon a unique proprietary technology platform, including Genprex’s initial product candidate, Oncoprex(TM) immunogene therapy for non-small cell lung cancer (NSCLC). Genprex’s platform technologies are designed to administer cancer fighting genes by encapsulating them into nanoscale hollow spheres called nanovesicles, which are then administered intravenously and taken up by tumor cells where they express proteins that are missing or found in low quantities. Oncoprex has a multimodal mechanism of action whereby it interrupts cell signaling pathways that cause replication and proliferation of cancer cells, re-establishes pathways for apoptosis, or programmed cell death, in cancer cells, and modulates the immune response against cancer cells. Oncoprex has also been shown to block mechanisms that create drug resistance. For more information, visit the company’s website at www.Genprex.com.

NOTE TO INVESTORS: The latest news and updates relating to GNPX are available in the company’s newsroom at http://nnw.fm/GNPX

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Trovagene Presents Positive Clinical Data from Ongoing Phase 2 Study of Onvansertib in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Trovagene Presents Positive Clinical Data from Ongoing Phase 2 Study of Onvansertib in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

  • Trial leads to discovery that onvansertib stops rise in PSA in patients with treatment-resistant, highly-aggressive and difficult-to-treat androgen-receptor variant 7 (AR-V7) tumors
  • Data demonstrates efficacy of onvansertib in patients showing early signs of resistance to androgen receptor signaling (ARS) inhibitor, Zytiga®
  • Addition of onvansertib appears to extend the duration of response to ARS inhibitor therapy in this incurable and lethal cancer

SAN DIEGO, Aug. 26, 2019 /PRNewswire/ — 
Trovagene, Inc. (Nasdaq: TROV), a clinical-stage, Precision Cancer Medicine™ oncology therapeutics company developing drugs that target cell division (mitosis), for the treatment of various cancers including prostate, colorectal and leukemia, today announced the presentation of positive clinical data from its ongoing Phase 2 clinical trial of onvansertib in combination with Zytiga® (abiraterone acetate)/prednisone, an androgen-receptor signaling (ARS) inhibitor, in metastatic Castration-Resistant Prostate Cancer (mCRPC), at the 20th Asia-Pacific Prostate Cancer Conference in Melbourne, Australia. These data demonstrate the efficacy of onvansertib in patients showing resistance to the ARS inhibitor, Zytiga® (Johnson & Johnson), including those with the highly-aggressive and difficult-to-treat androgen receptor variant 7 (AR-V7) tumor.

Trovagene is a clinical-stage oncology therapeutics company, using a precision medicine predictive biomarker approach to develop drugs that target cell division (mitosis) for the treatment of leukemias, lymphomas and solid tumor cancers. Onvansertib, its lead drug candidate, is a first-in-class, 3rd generation, highly-selective oral Polo-like Kinase 1 (PLK1) Inhibitor.  The Company currently has two ongoing open-label clinical trials: a Phase 1b/2 trial in acute myeloid leukemia (AML) and a Phase 2 trial in metastatic castration-resistant prostate cancer (mCRPC).

“We have discovered that adding onvansertib to daily ARS inhibitor therapy changes the trajectory of resistance in patients harboring AR-V7, as demonstrated by the immediate decrease in serum PSA levels in patients showing initial signs of resistance to Zytiga®,” said Mark Erlander, PhD, Chief Scientific Officer of Trovagene. “The inhibition of the PLK1 enzyme by onvansertib appears to enhance the efficacy of Zytiga® by repressing the ARS pathway, which is consistent with preclinical data.”

In the ongoing Phase 2 clinical trial of onvansertib, a first-in-class, oral and highly-selective PLK1 inhibitor, patients are being tested with a simple blood test to assess whether they are positive for AR-V7.  In all four patients who tested positive for AR-V7, thus far, an immediate decrease in their serum PSA levels was observed. To-date, two of these patients have achieved the primary efficacy endpoint of disease control. Importantly, while on Zytiga® alone the PSA level for one of the AR-V7 positive patients had a greater than five-fold rise in the two months prior to enrollment and treatment in the trial. Once onvansertib was added to Zytiga®, the patient’s PSA level stopped rising and immediately decreased; the patient remains on treatment.

Additionally, since presenting early data at the American Association for Cancer Research in April, a second arm (Arm B) with a two-week dosing schedule and 50% greater drug exposure to onvansertib over the treatment course, was added to the trial. Preliminary efficacy with PSA stabilization or reduction was observed in the initial three patients enrolled, suggesting that a shorter dosing schedule may maximize response to treatment. Importantly, no unexpected, off-target toxicities have been reported in patients treated to-date.

mCRPC is an incurable and lethal cancer. Nearly all patients with prostate cancer will progress to castration resistance, indicated by increasing serum PSA levels despite castrate levels of testosterone and progress to metastases. 10% to 20% of prostate cancers progress to castration resistant prostate cancer (CRPC) within 5 years of diagnosis, and 84% of newly diagnosed CRPC have metastases. The median survival of patients following diagnosis of castration resistance ranges between 15 and 36 months. The standard-of-care first-line treatment are ARS inhibitors, Zytiga® (Johnson & Johnson) or Xtandi® (Pfizer); however, resistance to these drugs typically develops within 9 to 15 months of initiating treatment. Additionally, up to 30% of patients have the highly-aggressive and ARS-resistant AR-V7. These patients have a shorter progression-free survival (PFS), overall survival (OS) and a poor prognosis. Current treatment for these patients is limited to toxic chemotherapy and there are no effective targeted therapies available.

About Onvansertib

Onvansertib is a first-in-class, third-generation, oral and highly-selective adenosine triphosphate (ATP) competitive inhibitor of the serine/threonine polo-like-kinase 1 (PLK1) enzyme, which is over-expressed in multiple cancers including leukemias, lymphomas and solid tumors. Onvansertib targets the PLK1 isoform only (not PLK2 or PLK3), is orally administered and has a 24-hour half-life with only mild-to-moderate side effects reported. Trovagene believes that targeting only PLK1 and having a favorable safety and tolerability profile, along with an improved dose/scheduling regimen will significantly improve on the outcome observed in previous studies with a former panPLK inhibitor in AML.

Onvansertib has demonstrated synergy in preclinical studies with numerous chemotherapies and targeted therapeutics used to treat leukemias, lymphomas and solid tumor cancers, including irinotecan, FLT3 and HDAC inhibitors, taxanes and cytotoxins. Trovagene believes the combination of onvansertib with other compounds has the potential to improve clinical efficacy in acute myeloid leukemia (AML), metastatic castration-resistant prostate cancer (mCRPC), non-Hodgkin lymphoma (NHL), colorectal cancer and triple-negative breast cancer (TNBC), as well as other types of cancer.

Trovagene has an ongoing Phase 2 clinical trial of onvansertib in combination with Zytiga® (abiraterone acetate)/prednisone in patients with mCRPC who are showing signs of early progressive disease (rise in PSA but minimally symptomatic or asymptomatic) while currently receiving Zytiga®. The trial was accepted by the NLM and is now posted to www.clinicaltrials.gov, with a NCT number of NCT03414034.

Trovagene has an ongoing Phase 1b/2 Study of onvansertib in combination with FOLFIRI and Avastin® for second-line treatment in patients with mCRC with a KRAS mutation. The trial was accepted by the NLM and is now posted to www.clinicaltrials.gov, with a NCT number of NCT03829410. The trial is being conducted at three prestigious cancer centers: USC Norris Comprehensive Cancer Center, Hoag Cancer Center and The Mayo Clinic.

Trovagene has an ongoing Phase 1b/2 clinical trial of onvansertib in combination with low-dose cytarabine or decitabine in patients with relapsed or refractory AML that was accepted by the National Library of Medicine (NLM) and is now posted to www.clinicaltrials.gov, with a NCT number of NCT03303339. Onvansertib has been granted orphan drug designation by the FDA in the U.S. and by the EC in the European Union for the treatment of patients with AML. 

Trovagene licensed onvansertib (also known as NMS-1286937 and PCM-075) from Nerviano Medical Sciences (NMS), the largest oncology-focused research and development company in Italy, and a leader in protein kinase drug development. NMS has an excellent track record of licensing innovative drugs to pharma/biotech companies, including Array (recently acquired by Pfizer), Ignyta (acquired by Roche) and Genentech.

About Trovagene, Inc.

Trovagene is a a clinical-stage, Precision Cancer Medicine™ oncology therapeutics company developing drugs that target cell division (mitosis), for the treatment of various cancers including leukemias, lymphomas and solid tumors. Trovagene has intellectual property and proprietary technology that enables the Company to analyze circulating tumor DNA (ctDNA) and clinically actionable markers to identify patients most likely to respond to specific cancer therapies. Trovagene plans to continue to vertically integrate its tumor genomics technology with the development of targeted cancer therapeutics.  For more information, please visit 
https://www.trovageneoncology.com.

Forward-Looking Statements

Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. These statements may be identified by the use of words such as “anticipate,” “believe,” “forecast,” “estimated” and “intend” or other similar terms or expressions that concern Trovagene’s expectations, strategy, plans or intentions. These forward-looking statements are based on Trovagene’s current expectations and actual results could differ materially.  There are a number of factors that could cause actual events to differ materially from those indicated by such forward-looking statements.  These factors include, but are not limited to, our need for additional financing; our ability to continue as a going concern; clinical trials involve a lengthy and expensive process with an uncertain outcome, and results of earlier studies and trials may not be predictive of future trial results; our clinical trials may be suspended or discontinued due to unexpected side effects or other safety risks that could preclude approval of our product candidates; uncertainties of government or third party payer reimbursement; dependence on key personnel; limited experience in marketing and sales; substantial competition; uncertainties of patent protection and litigation; dependence upon third parties; our ability to develop tests, kits and systems and the success of those products; regulatory, financial and business risks related to our international expansion and risks related to failure to obtain FDA clearances or approvals and noncompliance with FDA regulations. There are no guarantees that any of our technology or products will be utilized or prove to be commercially successful.  Additionally, there are no guarantees that future clinical trials will be completed or successful or that any precision medicine therapeutics will receive regulatory approval for any indication or prove to be commercially successful. Investors should read the risk factors set forth in Trovagene’s Form 10-K for the year ended December 31, 2018, and other periodic reports filed with the Securities and Exchange Commission.  While the list of factors presented here is considered representative, no such list should be considered to be a complete statement of all potential risks and uncertainties. Unlisted factors may present significant additional obstacles to the realization of forward-looking statements. Forward-looking statements included herein are made as of the date hereof, and Trovagene does not undertake any obligation to update publicly such statements to reflect subsequent events or circumstances.

Trovagene Contact: 
Vicki Kelemen 
VP, Clinical Development and Investor Relations 
858-952-7652 

vkelemen@trovagene.com 

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SOURCE Trovagene, Inc.

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What If Yields Turn Negative?

Inverted yield curve? So what! What if yields turn negative?

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the “Balanced” section)

The Dow Jones Industrial fell more than 800 points on August 14
th when the yield on the 10-year treasury bond fell below that of the 2-year treasury note.  Much has been made about the inversion of the yield curve and how that often signals a recession.  Less has been made about the fact that the government bond yields are now below 2% and appear to be headed lower.  Prominent bond experts such as Mohamed El-Erian and Alan Greenspan say they would not be surprised to see rates go negative.  The reason for the decline is obvious.  Investors are losing confidence in the economy and moving money from the stock market to places of security.  Will this lack of confidence become a self-fulfilling prophesy as decreased investment and spending cause economic weakness (bear case) or is it a mere coincidence (bull case)?

Research – 1-800-Flowers.com (FLWS) – Why this quarter stands out.

Friday, August 23, 2019

1-800-Flowers.com (FLWS)

Setting Expectations That Can Be Beat

1-800-FLOWERS.COM, Inc. is the leading provider of gourmet and floral gifts for all occasions. For nearly 40 years, 1-800-FLOWERS® has been helping deliver smiles for customers with gifts for every occasion, including fresh flowers, premium, gift-quality fruits and other gourmet items from Harry & David®, popcorn and specialty treats from The Popcorn Factory®; cookies and baked gifts from Cheryl’s®; premium chocolates and confections from Fannie May®; gift baskets and towers from 1-800-Baskets.com®; premium English muffins and other breakfast treats from Wolferman’s; carved fresh fruit arrangements from FruitBouquets.com; and top quality steaks and chops from Stock Yards®. The Company’s BloomNet® international floral wire service provides a broad range of quality products and value-added services designed to help professional florists grow their businesses profitably.

Michael Kupinski, Senior Research Analyst, DOR, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • Solid quarter. Overachieves revenue expectations, while meeting our adj. EBITDA (cash flow) estimates. Total company revenues were $259.4 mil. versus our $251.9 mil. estimate. The largest upside variance was in Gourmet Food, $72.5 mil. versus our $66.5 mil. estimate, which benefited from strong underlying 7% revenue growth and a bump from Easter. Adj. EBITDA loss of $2.7 mil. was on target.
  • Why the quarter stands out.   We would note that the company had a solid quarter in spite of an incremental $2.5 mil. in compensation expenses year over year. Furthermore, with the acquisition of Shari’s Berries in August, the company is expected to…



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This Company Sponsored Research is provided by Noble Capital Markets, Inc., a FINRA and S.E.C. registered broker-dealer (B/D).

*Analyst
certification and important disclosures included in full report. 
NOTE: investment decisions should not be based upon the content of
this research summary.  Proper due diligence is required before
making any investment decision.
 

Research – Aurania Resources (ARU.V) – A Growing Number of Targets

Tuesday, August 13, 2019

Aurania Resources (ARU.V)

Gaining Momentum

Aurania Resources Ltd. is a junior mining exploration company engaged in the identification, evaluation, acquisition, and exploration of mineral property interests, with a focus on precious metals and copper. Its flagship asset, The Lost Cities – Cutucu Project, is in southeastern Ecuador in the Province of Morona-Santiago. The project includes 42 mineral exploration concessions encompassing an area of approximately 208,000 hectares, or 2,080 square kilometers. The company’s common shares are traded on the TSX Venture Exchange under the symbol “ARU”, the OTCQB Venture Market under the symbol “AUIAF” and on the Frankfurt Exchange under the symbol “20Q”.

Mark Reichman, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • Scout drilling to begin in mid-September.  Aurania Resources recently provided an update on its planned drilling program at Yawi, where four of its seventeen gold and silver targets are located within the Lost Cities project area. Management expects all permits, including scout drilling and water permits, to be in place for drilling to begin on the first of the Yawi targets in mid-September 2019.
  • Growing list of gold and silver targets.   The most recent addition to the target list is “Apai”, an epithermal target located near the southern boundary of the project. Aurania recently engaged Metron, Incorporated to…



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*Analyst
certification and important disclosures included in full report. 
NOTE: investment decisions should not be based upon the content of
this research summary.  Proper due diligence is required before
making any investment decision.
 

Will Iran Continue to Grow Their Nuclear Program?

Will Iran Continue to Grow Their Nuclear Program?

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the “Balanced” section)

In 2015, Iran agreed to a long-term nuclear accord with six other world powers, called the Joint Comprehensive Plan of Action. It came after years of tension over Iran’s efforts to develop nuclear weapons, even though they insisted the program was entirely peaceful, the international community was not convinced. The other side of the deal consisted of lifting sanctions that were crippling Iran’s economy. It was set to last 15 years after the “implementation day” which took place January of 2016. In May 2018, President Donald Trump withdrew the United States from the agreement, stating it failed to address Iran’s ballistic missile program. He reimpose sanctions and is now moving to diminish Iran’s oil exports. Resulting from this, Iranian President Hassan Rouhani announced they will no longer adhere to certain limits as they have not seen the deal’s envisioned economic benefits.

Aurania Refines Its Newly Discovered Apai Gold-Silver Target in Southeastern Ecuador

Aurania Refines Its Newly Discovered Apai Gold-Silver Target in Southeastern Ecuador

Toronto, Ontario–(Newsfile Corp. – August 22, 2019) – Aurania Resources Ltd. (TSXV: ARU) (OTCQB: AUIAF) (FSE: 20Q) (“Aurania” or the “Company”) reports that further exploration has refined its Apai target for gold and silver in its Lost Cities – Cutucu Project (“Project”) in southeastern Ecuador. Furthermore, Apai is suspected to be linked geologically to the copper target that SolGold PLC (“SolGold”) has identified on its mineral concessions 10 kilometres (“km”) to the south.

Aurania’s Chairman and CEO commented, “We have now identified twenty epithermal systems in 50% of the area of the Lost Cities Cutucu Project that has been field-checked by our exploration team. We’re excited that we’re finding epithermals, that are prime gold and silver targets, aligned along fault corridors and potentially fed by porphyry systems, a relationship seen in clusters of deposits throughout the Pacific Rim. Our task is to use field characteristics and scout drilling to rank these targets for further focused exploration to create shareholder value.”

Apai Target

Recent field work has shown that the centre of the Apia target is marked by abundant sinter blocks over an area of at least 1.2km by 0.5km. Younger rocks partially cover the sinter, making it impossible to estimate its true size at present. Veins of opal and chalcedony that have been found in outcrop, and along with sinter, are common features of the top of epithermal systems. The highest arsenic values are found in a stream that drains the sinter, while the surrounding area that is 4.5 km long and 3km wide, contains elevated levels of this important pathfinder element for gold in epithermal systems. Naturally-occurring mercury has been identified over an area that is larger than the zone of arsenic enrichment, and encloses the opal and chalcedony veins as well as hydrothermal breccias (Figure 1). Streams in the Apai target area also contain elevated concentrations of silver and pathfinder elements including antimony, selenium and bismuth.

Possible Link to Adjacent Mineralization

Detailed interpretation of satellite imagery for Aurania by an independent consultant shows that the Apai epithermal target lies within the same fault system as the high-grade copper found in a breccia in SolGold’s “Anomaly 2” in its Coangos 2 concession (Figure 1). These targets may provide an example of the common relationship of epithermal gold-silver deposits lying along trend of porphyry copper-related deposits within fault-bounded corridors. Such linked deposits are believed to arise when hot, hydrothermal fluids responsible for copper mineralization in porphyries, rise and cool along fault corridors, depositing gold and silver in epithermal deposits. [Note that Aurania has not independently verified the results reported by SolGold and is relying on the information provided in SolGold’s press release issued on May 10, 2019].

Next Steps

  • Undertake soil sampling in the drainage basins in which elevated silver and pathfinder elements were detected in the stream sediment sampling program;
  • Undertake detailed alteration mapping – this is to detect the minerals that have developed from the reaction of hot, metal-bearing fluids with the host-rocks. These alteration minerals are typically arranged in a roughly concentric pattern around mineralized systems and provide a way of vectoring toward the heart of the system where the metals are located;
  • Geophysics will be considered; and
  • Application has been made for the water-use permit for scout drilling, which requires several steps:
    • Samples from streams from which water is to be pumped for scout drilling are undergoing repeated testing and analysis to establish a baseline for comparison with tests made at regular intervals during and after drilling. This work is necessary to demonstrate that there is no contamination of water from the drilling and serves to protect the Company against potential and unfounded allegations in the future;
    • The sites from which water is planned to be taken have been reviewed by an independent consultant who has verified that the streams would support the pumping of the 1.5 litres per second required for drilling, without significantly affecting flow levels; and
    • The above information has been included in an application for water-use that is being submitted to the controlling entity called SENAGUA.

Cannot view this image? Visit: https://orders.newsfilecorp.com/files/2477/47158_20c232683425f896_001.jpg

Figure 1. Map showing the location of the sinter at the centre of the Apai target and the extent of naturally-occurring arsenic and mercury in stream sediments relative to the location of the copper mineralization reported by Solgold from its mineral concessions immediately south of Aurania’s Lost Cities – Cutucu Project.

To view an enhanced version of Figure 1, please visit:
https://orders.newsfilecorp.com/files/2477/47158_20c232683425f896_001full.jpg

Sample Analysis & Quality Assurance / Quality Control (“QAQC”)

The samples were prepared for analysis at ALS Global’s (“ALS”) lab in Quito, Ecuador. The stream sediment samples were wet-sieved through a 20 mesh (0.84mm) screen in the field and placed in cloth bags so that excess water could drain. The samples were transported from the field to Aurania’s field office in Macas, Ecuador and batched for delivery to ALS’s preparation lab in Quito for drying and screening at 80 mesh (0.18mm sieve aperture). 250g of the -80 mesh silt was pulverized to 85% passing 0.075mm, and was packaged by ALS for analysis.

ALS’s preparation lab in Quito sent the prepared samples to its analytical facility in Lima, Peru for analysis: a 0.5g split of the -80 mesh fraction of the stream silt underwent digestion with aqua regia and the liquid was analyzed for 48 elements by ICP-MS. Apart from being analyzed by ICP-MS, gold was also analyzed by fire assay with an ICP-AES finish.

ALS reported that the analyses had passed its internal QAQC tests. In addition, Aurania’s analysis of results from its QAQC samples showed the batches reported on above, lie within acceptable limits.

Qualified Person

The technical information contained in this news release has been verified and approved by Jean-Paul Pallier, MSc. Mr. Pallier is a designated EurGeol by the European Federation of Geologists and is a Qualified Person as defined by National Instrument 43-101, Standards of Disclosure for Mineral Projects of the Canadian Securities Administrators.

About Aurania

Aurania is a junior mineral exploration company engaged in the identification, evaluation, acquisition and exploration of mineral property interests, with a focus on precious metals and copper. Its flagship asset, The Lost Cities – Cutucu Project, is located in the Jurassic Metallogenic Belt in the eastern foothills of the Andes mountain range of southeastern Ecuador.

Information on Aurania and technical reports are available at www.aurania.com and www.sedar.com, as well as on Facebook at https://www.facebook.com/auranialtd/, Twitter at https://twitter.com/auranialtd, and LinkedIn at https://www.linkedin.com/company/aurania-resources-ltd-.

For further information, please contact:

Carolyn Muir
Manager – Investor Services
Aurania Resources Ltd.
(416) 367-3200
carolyn.muir@aurania.com

Dr. Richard Spencer
President
Aurania Resources Ltd.
(416) 367-3200
richard.spencer@aurania.com

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Forward-Looking Statements

This news release may contain forward-looking information that involves substantial known and unknown risks and uncertainties, most of which are beyond the control of Aurania. Forward-looking statements include estimates and statements that describe Aurania’s future plans, objectives or goals, including words to the effect that Aurania or its management expects a stated condition or result to occur. Forward-looking statements may be identified by such terms as “believes”, “anticipates”, “expects”, “estimates”, “may”, “could”, “would”, “will”, or “plan”. Since forward-looking statements are based on assumptions and address future events and conditions, by their very nature they involve inherent risks and uncertainties. Although these statements are based on information currently available to Aurania, Aurania provides no assurance that actual results will meet management’s expectations. Risks, uncertainties and other factors involved with forward-looking information could cause actual events, results, performance, prospects and opportunities to differ materially from those expressed or implied by such forward-looking information. Forward looking information in this news release includes, but is not limited to, Aurania’s objectives, goals or future plans, statements, exploration results, potential mineralization, the corporation’s portfolio, treasury, management team and enhanced capital markets profile, the estimation of mineral resources, exploration and mine development plans, timing of the commencement of operations and estimates of market conditions. Factors that could cause actual results to differ materially from such forward-looking information include, but are not limited to, failure to identify mineral resources, failure to convert estimated mineral resources to reserves, the inability to complete a feasibility study which recommends a production decision, the preliminary nature of metallurgical test results, delays in obtaining or failures to obtain required governmental, regulatory, environmental or other project approvals, political risks, inability to fulfill the duty to accommodate indigenous peoples, uncertainties relating to the availability and costs of financing needed in the future, changes in equity markets, inflation, changes in exchange rates, fluctuations in commodity prices, delays in the development of projects, capital and operating costs varying significantly from estimates and the other risks involved in the mineral exploration and development industry, and those risks set out in Aurania’s public documents filed on SEDAR. Although Aurania believes that the assumptions and factors used in preparing the forward-looking information in this news release are reasonable, undue reliance should not be placed on such information, which only applies as of the date of this news release, and no assurance can be given that such events will occur in the disclosed time frames or at all. Aurania disclaims any intention or obligation to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, other than as required by law.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/47158

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Reserach – Great Lakes Dredge & Dock (GLDD) – Backlog Rebound Expected

Wednesday, August 21, 2019

Great Lakes Dredge & Dock (GLDD)

Positive Outlook Drives Up Price Target

Great Lakes Dredge & Dock is a marine and environmental infrastructure contractor, and the largest dredging company in the United States. Headquartered in suburban Chicago, the company provides port expansion and maintenance, coastal restoration, river dredging and environmental restoration for public and private entities worldwide. In June 2019, the Environmental & industrial (E&I) business was sold for $17.5 million in cash and the company is now pure play on the dredging market.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • 2H2019 Backlog rebound remains likely.  Since the start of 3Q2019, total low bids equal ~$91 million and most of the awards should be announced shortly. ~$110 million of low bids not awarded in 2Q2019 includes $93 million of option work in Jacksonville.
  • Introducing 2020 EBITDA estimate of $140.5 million, up from $131.2 million in 2019.  The outlook into next year appears positive with continued high bidding activity on port/channel deepening projects and…



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The inverted yield curve: what does this really indicate?

The inverted yield curve: what does this really indicate?

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the “Balanced” section)

The news of an inverted yield curve has been lingering around market news headlines for days. For reference, an inverted yield curve occurs when long term rates are less than short term rates. It typically indicates that the chance of an economic recession in the future is high. With those headlines glooming over the average investor, it is important to know what the inverted U.S. yield curve represents, and what the warning signs indicate.

Can Germany Survive the Trade War?

Can Germany Survive the Trade War?

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the “Balanced” section) 

Germany’s economy has suffered due to declines in exports in the industry and automobile sectors. German manufacturers are presented with increasing struggles as the U.S.-China trade war over tariffs has led to a global economic slowdown and Britain’s exit from the EU leads to greater turmoil. Germany’s GDP declined by 0.1% overall, and the government is pressured with providing greater fiscal stimulus. The economy ministry stated that fiscal action is necessary to prevent Germany from falling into a technical recession. Germany, Europe’s biggest economy, is a necessary component to the economic growth and standing of its neighbors. Consumer demand and spending has been strong, helping to supplement the economy but is beginning to wane.

Research – Tribune Publishing (TPCO) – Content to Drive Value

Tuesday, August 20, 2019

Tribune (TPCO)

Pushing To Be Ahead Of The Times

Tribune Publishing Company, formerly tronc, is a media company that publishes newspapers worldwide. The company operates in two segments, M and X. It publishes daily newspapers; weekly newspapers; and digital platforms, such as Websites and mobile applications. The company also provides various digital marketing services, which include the development of mobile Websites, search engine marketing and optimization, social media account management, and content marketing for its customers’ Web presence for small to medium size businesses. In addition, it offers TCA, a syndication and licensing business that provides daily news service and syndicated premium content to 1,700 media and digital information publishers. Tribune Publishing Company is headquartered in Chicago, Illinois.

Michael Kupinski, Senior Research Analyst, DOR, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • Marketing meeting highlights.  This report highlights notes from a marketing meeting in the Midwest with Terry Jimenez, the Chief Financial Officer and Michael Ferreter, Investor Relations.
  • Value for its content?   Management indicated that it is in discussions with tech companies to receive payment for some of its content. While the payments may seem somewhat….



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Microsoft Acquires PromoteIQ in an attempt to compete with Amazon

Microsoft Acquires PromoteIQ in an attempt to compete with Amazon

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the “Balanced” section) 

Advertising generates the majority of revenue in the social media and searching sections of the internet market. The main players in the technology sector rely heavily on the profits they receive from ads. Facebook and Twitter have become common areas for companies to advertise because it attracts a lot of foot traffic. On Monday, August 5, 2019, Microsoft announced it had acquired PromoteIQ, a small company that has focused on aiding retailers in including ads into their online stores. They have selected retail as a key industry to focus on, attempting to increase its market share in the public cloud sector. This acquisition was made with the hope of competing better with Amazon.

Growing Industry: What Should We Look For?

Growing Industry: What Should We Look For?

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the “Balanced” section) 

The cannabis industry has been a hot topic in headline news for the past couple of years. Many investors dive into this industry because it’s trending but have no idea where to put their money or what companies are doing to get ahead. It’s important to know the basics of the cannabis industry and to keep up with the laws surrounding the use and distribution, since this affects the growth outlook for cannabis stocks.