CAR-T Cancer Treatment: Part 3, When Breakthroughs Converge

Triple Technology to Engineer a Potent Anti-cancer Weapon, Part 3

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the “Balanced” section)

(click here for Part
1
or Part
2
)

Medical breakthroughs usually occur when science and industry collide through combinations of various disciplines. Right now, we are on the verge of witnessing a potential medical breakthrough for the treatment of cancer as three discoveries converge:

  1. Invention of CAR-T (Carl June, a scientist from University of Pennsylvania, pioneered CAR-T technology. Dr. June started treating cancer patients with it in 2010. In 2017, U.S. FDA approved the first two CAR-T medicines for the treatment of blood cancers)
  2. Introduction of Checkpoint
    Inhibitors
    (Bristol-Myers’s Opdivo and Merck’s Keytruda were approved by FDA for the treatment of cancer in 2014/2016, respectively. Since then, the agency has approved these medicines for the treatment of various types of cancer)
  3. Discovery of CRISP-Cas9 gene
    editing
    (In 2012, Jennifer Doudna, Emmanuelle Charpentier and Feng Zhang were credited for this eureka moment, as these scientists independently discovered CRISPR-Cas9 technology and predicted its significant potential. Jennifer (University of California, San Francisco), Emmanuelle Charpentier (Max Planck Institute) and Feng Zhang (Massachusetts Institute of Technology, MIT) were the inventors, respectively, of the technologies given rise to three emerging biotech companies: Intellia Therapeutics, CRISPR Therapeutics and Editas Medicine).

“Chimeric Antigen Receptor T cell therapy” (CAR-T) is a gene therapy designed to harness the potency of antibodies and T-lymphocytes into one single medicine for the treatment of cancer. CAR-T therapy could be viewed as a “living anti-cancer drug” as the medicine itself consists of a living cell, which is genetically engineered as a pharmaceutical “chimera” to find and destroy cancer cells (see Parts 1/2 of these series). Gene editing tools, such as CRISPR-Cas9, could be utilized to generate more effective CAR-T medicines (Figure 1).

Figure 1. Gene editing to engineer a “CAR-T
medicine”.
 A picture containing clock, device

Description automatically generated

 

 

 

 

 

 

 

Source: “T-cell tweaks to target tumors”. Nature 2017, 543:48-49

  1. Traditional CAR-T Design. Traditional CARs (shown in yellow) are inserted at a random location into the genome (DNA) of T cells. If the CAR-T is expressed constitutively (constant synthesis), the cells often enter a state called “exhaustion” (become inactive). 
  2. Use of CRISPR-Cas9. Gene-editing tool CRISPR–Cas9 used to replace the cell’s TCR-encoding gene (TCR – “natural T-cell receptor”, shown in green) with a CAR-T encoding sequence (shown in yellow). 
  3. Gene-edited CAR-T. CRISPR–Cas9-edited T cells express only one type of TCR, the CAR-T (shown in yellow and red), providing better anti-tumor responses than traditional CAR T cells. The natural TCR (green) has been removed.

Click here to read Part 1 or Part 2 of this series on the revolutionary advances happening in the science of cancer treatment.

U.S. second quarter labor costs increases by the smallest amount in 1 ½ years

U.S. labor costs has been experiencing its most sluggish growth in close to two years in the second quarter. This latest metric of minor inflation could open the door for the Federal Reserve to finally cut interest rates on Wednesday for the first time in a decade.

The standard measure of American labor costs, the Employment Cost Index, saw a meager increase of only 0.6%, the smallest gain the index has realized since the fourth quarter of 2017, the Labor Department reported Wednesday morning. The ECI had increased by 0.7% for two straight quarters now. In the 12 month period ending in June this year, the ECI rose a total of 2.7%, missing the mark of a 2.8% increase in the year through March.

The ECI is a trusted statistic by policymakers and economists, and is considered as one of the better indicators of sluggishness in the labor market. It is also viewed as a better predictor of core inflation. Labor costs were gaining in 2018 as a stable labor market in the U.S. drove up wage growth. The increase of these costs has sputtered since then.

The report came on the back of data released on Tuesday, showing a measure of inflation increased 1.6% in the 12 months to June, continuing a pattern of sluggish gains that have seen it miss the Fed’s key 2% target this year.

Low inflation combined with slowing economic growth are expected to nudge U.S. central bank officials to make a desired interest rate cut when they conclude a two-day policy meeting later on Wednesday. The U.S. economy is cooling from the boost seen last year, following a $1.5 trillion tax cut package that is soon fading out. The bitter trade war between the United States and China, slowing global growth, and Britain’s potential disorderly departure from the European Union are all compounding factors that are taking a negative toll on the American economy.

Prices of U.S. bond notes were trading higher on Wednesday while the dollar was largely unchanged against a medley of currencies as traders are keen to hear the awaited Fed’s decision on rates. U.S. stock index futures were up on this expectation.

Job gains in the second quarter, including the measurement of wages and salaries, accounts for 70 percent of employment costs, which rose 0.7% after rising by the same margin in the preceding period. Wages and salaries were up 2.9% in the 12 months through June.

Wages and salaries rose 0.6% in the private sector for the second quarter after increasing 0.7% in the first quarter. State and local government wages and salaries rose 0.5% after increasing 0.6% in the first quarter.

Benefits in the manufacturing industry rose a modest 0.5% after an impressive 0.9% gain in the first quarter. Overall, benefits have increased 2.3% in the 12 months through June, the smallest gain seen since the year-to-year period ending in March 2017, when benefits rose by 2.6%.

The ADP National Employment Report came out today and showed payrolls in the private sector jumped by 156,000 jobs in July after increasing 112,000 in June. The ADP report, which is developed by Moody’s Analytics, the trusted financial services and ratings company, has predicted the private payrolls component of the government’s employment with extreme accuracy in their reports in each of the last two months. It is likely that the ADP will do the same.

After employment numbers surged by 224,000 in June, economists expect to see employment to increase by 162,000 jobs. Compared to last year, job gains have been disappointing as a total of 172,000 per month in the first half of this year has been the average, which is far off the pace of 223,000 monthly average in 2018. The pace of job gains has remained above the roughly 100,000 per month necessary to keep up with the growth of the current working-age population. The unemployment rate is believed to stay at 3.7% in July like it was in June.

IPO Podcast – Kathy Ireland


The idea: Transition from Supermodel to Super Mogul with a pair of socks. Meet Kathy Ireland.

Parlayed teen modeling into supermodel then super mogul… Her multi-billion-dollar empire is now ranked among the top 50 licensing companies in the world with annual sales of $2 billion. Her personal fortune is over $500 million.

GUEST:

Perhaps best known for appearing in 13 consecutive Sports Illustrated swimsuit issues, Supermodel Kathy Ireland left that life behind a long time ago in pursuit of her entrepreneurial roots. In 1993 founded her brand marketing company, kathy ireland Worldwide (yes, lower case k and i). Her first product: a pair of socks. Although kiWW had a rocky start, she never gave up. She sold 100,000,000 pairs of socks (yes, that’s millions). Today, with annual sales north of $2 billion, Kathy and her business are regarded as one of the most enduring American success stories by the likes of Bill Gates and Warren Buffett (who has been a mentor to Kathy for 30 years). This is a story you’ll want to hear. On IPO.

Running time 52:03

HIGHLIGHTS:

10:17 – Interview with Ms. Ireland

14:45 – “I was an aging, pregnant model at my kitchen table – no one would buy my products because my name was on it.”

32: 33 – “I was told the socks were a blowout… having our first child in diapers, a blowout had a very different meaning.”

HOST:

Brant Pinvidic, Hollywood producer and director (Bar Rescue, Biggest loser), C-level corporate consultant, columnist for Forbes and author (3-Minute Rule – Penguin Random House, October 2019).

The most innovative Ideas, the inspirational People behind them, and the wealth of Opportunities they create… that’s IPO from Channelchek.

watch the IPO series trailer

Research – ACCO Brands (ACCO) – Record 2Q Results; What’s In-store for the Rest of the Year?

Wednesday, July 31, 2019

ACCO Brands (ACCO)

Record 2Q Results; What’s In-store for the Rest of the Year?

ACCO Brands Corporation designs, manufactures, sources, markets, and sells office products, academic supplies, and calendar products primarily in the United States, Canada, Northern Europe, Brazil, Australia, and Mexico. It operates through three segments: ACCO Brands North America, ACCO Brands EMEA, and ACCO Brands International.

Joe Gomes, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • Record 2Q19 Results. ACCO Brands reported record 2Q19 operating results with revenue up 4.0% to $518.7 million and adjusted EPS of $0.36 versus $0.32 last year. We were forecasting revenue of $495 million and adjusted EPS of $0.33. A surprisingly strong North American business led the top line improvement, while tight expense controls, pricing increases to offset inflation and tariffs, and a reduced share count benefited the bottom line.
  • Strong North America. Broad sales growth across all channels in North America drove an 8.9% growth in segment revenue. Pricing and, to a lesser extent…



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Research – Eagle Bulk Shipping (EGLE) – A Tough Quarter But Set Up for 2H2018 Rebound

Tuesday, July 30, 2019

Eagle Bulk Shipping (EGLE)

Tough Quarter But Set Up for 2H2019 Rebound

Eagle Bulk Shipping Inc. is a US-based drybulk owner-operator focused on the Supramax/Ultramax mid-size asset class, which ranges from 50,000 and 65,000 deadweight tons in size; these vessels are equipped with onboard cranes allowing for the self-loading and unloading of cargoes, a feature which distinguishes them from the larger classes of drybulk vessels and provides for greatly enhanced flexibility and versatility- both with respect to cargo diversity and port accessibility.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • Another solid quarter of TEC rate outperformance, but light of expectations. TCE revenue of $38.9 million and TCE rates of $9,732/day were below our estimates of $40.6 million and $10,000/day, respectively. Adjusted 2Q2019 EBITDA of $10.4 million was below our estimate and down sequentially from $15.3 million in 1Q2019. 8AM EST call today (7/30) — number is 844-282-4411 and code is 6173884.
  • Adjusting estimates to reflect current dry bulk market outlook, expanded scrubber program and pending acquisition. We are moving our 2019 EBITDA estimate to $70.5 million from $75.8 million. Estimate is based on…



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Moderate Increase in U.S. Prices and Consumer Spending

In June, prices and U.S. consumer spending rose, indicating slower economic growth and inflation which could lead to the Federal Reserve, for the first time in decade, cutting interest rates. On Tuesday, the Commerce Department, stated that consumer spending which is a majority of economic activity in the United States, had gained a 0.3% increase in services offsetting the decline in motor vehicle purchases.

Consumer spending rose 0.5% from data in May. The second-quarter gross domestic report from last Friday, presented a 4.3% annualized rate in consumer spending increased, growing from 1.1% through the period of January to March. The GDP was impacted by weakened exports, inventory accumulation, and business investment which had been offset by robust consumer spending.

The economy grew by 3.1% in the first quarter which declined last quarter growing at 2.1%. Both food and energy prices fell while consumer prices increased by 0.1% in June. In May, the personal consumption expenditures (PCE) price index saw an increase of 0.1%. The PCE price index increased by 1.4%, over the last year into June.

The PCE price index heightened by 0.2%, increasing by three straight months in a row. In May, the PCE price index had an annual increase from 1.5% to 1.6%. The Fed uses the core of the PCE index to measure inflation which was lower than the 2% target this year by the U.S. central bank. On Tuesday, the Fed were initially going to have a two-day policy meeting regarding the slowing economic growth. The U.S. economy facing decreased global growth and trade tension, has been slowing due to fading stimulus of last year’s $1.5 trillion tax cut.

In June, consumer spending increased by 0.2% when adjusting for inflation. In May, there was an increase of 0.3% in real consumer spending. Spending on goods increased by 0.3% last month. Also, there was an increase in services by 0.3%. In June, consumer spending was supplemented by an increase of 0.4% in personal income. There was an increase in wages by 0.5%. There was an increase in savings from $1.31 trillion to $1.34 trillion since May.

Tensions Rise on First Federal Reserve Rate Cut in a Decade

On Wednesday, the United States Federal Reserve policymakers may cut interest rates for the first time in a decade. Jerome Powell, the Fed Chairman, will have to convey to the central bank the necessity of a stimulant. There is a high possibility that the Fed chief will see at least one dissent.

Eric Rosengren, the Boston Fed President, stated he does not want an ease in policy, “if the economy is doing perfectly well without that easing.” In September 2007, Charles Evans, Chicago Fed President, voted for a half-percentage-point rate cut, which was the first of many that would decrease the federal funds rate to almost zero. Esther George, Kansas City Fed President, may also vote against a rate cut. George stated, that monetary policy was “in a good range,” but is “prepared to adjust those views” if risks arise. George and Rosengren will be among 10 voters on the rate cut on Wednesday and they have the ability to change the normal Fed consensus-driven approach. If policymakers choose to dissent, it would be more controversial than the Fed’s last four rate-cutting cycles. In three of the last four, 1998, 2001, 2007, the votes were unanimous for lower rates. Thomas Hoenig, the previous Kansas City Fed President, was the only dissent in 1995.

Powell is under pressure by the Trump Administration over not boosting the economy enough and could face more adversity if either voter dissents. On Wednesday, at 2 p.m. EDT (1800 GMT), the Fed will release its policy statement and a press conference will be held by Powell after. Powell should be aware of a dissenter’s concerns regarding a series of cuts, or he can choose to reinforce a “dovish” stance. Voter dissent is not an absolute thing, and Fed policymakers may be apt to change after the two-day meeting. Powell is expected to cut rates, citing the tensions between the U.S. and China as a reason for slower global economic growth and growing risk of inflation. The constantly changing economy has led members such as George to take different stances, and even possibly dissent.

DOVISH

George dissented seven times in 2013, worrying that the Fed’s bond-buying strategy could cause unnecessary inflation. George was willing to join the majority when the Fed, at the year’s last policy meeting, stated it would reduce the purchases of stimulative bonds.

The unemployment rate ended at 6.7% last year and is now 3.7%. Inflation is at 1.8%, the Fed’s preferred measure, which is still below the U.S. central bank’s 2% annual inflation target. Both consumer spending and the economy are growing at an almost unsustainable rate while unemployment is almost at a 50-year low. The overall attitude of the Fed may have shifted since fewer voters are expected to dissent. Narayana Kocherlakota, previous Minneapolis Fed President, who had dissented multiple times, stated “I do hope that there is a dissent next week that goes on record as opposing the (Fed’s expected) 25-basis-point cut. The Fed has become more ‘dovish’ – it seems more willing to court higher inflation in 2019 than in 2015, even though it’s clearly doing better on the employment mandate.” A voter who dissents would present to investors that the Fed is aware of the risks of inflation.

Is The IRS Cracking Down On Cryptocurrency?

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the “Balanced” section)

The IRS is cracking down on bitcoin and other cryptocurrency holders who haven’t reported earnings or paid taxes on trades. In August, about 10,000 bitcoin owners will receive letters from the IRS requiring payment on any unreported cryptocurrency trades. IRS established a Virtual Currency Compliance Campaign addressing issues related to noncompliance on cryptocurrency. The Virtual Currency Compliance campaign focusses on “noncompliance related to the use of virtual currency through multiple treatment streams including outreach and examinations. The compliance activities will follow the general tax principles applicable to all transactions in property, as outlined in Notice 2014-21. Taxpayers with unreported virtual currency transactions are urged to correct their returns as soon as practical.” IRS has conducted ongoing compliance investigations to find cryptocurrency holders and sent previous initial educational letters to taxpayers. Chuck Rettig, the IRS Commissioner stated, “the IRS is expanding our efforts involving virtual currency, including increased use of data analytics. We are focused on enforcing the law and helping taxpayers fully understand and meet their obligations.” Last year, a court order for Coinbase, a cryptocurrency exchange platform, required the turnover of information to IRS, on around 14,000 accounts. The IRS targeted accounts on Coinbase who purchased or had sales of more than $20,000 worth of cryptocurrencies between the period of 2013 to 2015. The IRS had only received about 900 filing reports relating to cryptocurrency transactional gains or losses even though a large majority of Americans use regulated cryptocurrency exchanges such as Coinbase.

Research – Great Panther Mining Limited (GPL) – Turning the Corner

Monday, July 29, 2019

Great Panther Mining Limited (GPL)

Turning the Corner

Great Panther Silver Ltd is a precious metals mining and exploration company. It owns two mines Topia and Guanajuato Mine Complex (GMC). The Topia operations produce silver, gold, lead, and zinc whereas the GMC operation produces silver and gold.

Mark Reichman, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • GPL reports second quarter loss. Great Panther Mining reported a second quarter loss of ($5.6) million, or ($0.02) per share, compared with our net income estimate of $357 thousand, or $0.00 per share. The variance to our estimate was due to higher costs.
  • Adjusting estimates. We are lowering our 2019 EPS and EBITDA estimates to ($0.01) and $36.3 million, from $0.01 and $39.3 million, respectively. Our full year 2020 EPS and EBITDA estimates have also been…



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Research – Orion Group Holdings (ORN) – Transition Quarter to Strong Second Half Rebound

Monday, July 29, 2019

Orion Group Holdings (ORN)

Transition Quarter to Strong Second Half Rebound.

Orion Group Holdings Inc is a US-based company which provides solutions in marine construction, design and specialty services both on and off the water in the continental US, Alaska, Canada, and the Caribbean Basin.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • 2Q2019 results out on Wednesday July 31st after the market closes (AMC). Call with management on August 1st at 10:00 am ET. Call number is 201-493-6739 and code is Orion.
  • A transition quarter due to lower margin backlog burn off. Our 2Q2019 revenue/EBITDA estimates are…



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Research – Eurodry (EDRY) – Positive Impact from Preferred Changes and Recent Dry Bulk Market Rebound.

Monday, July 29, 2019

Eurodry (EDRY)

Positive Impact from Preferred Changes and Recent Dry Bulk Market Rebound.

EuroDry Ltd. was formed on January 8, 2018 under the laws of the Republic of the Marshall Islands and trades on the NASDAQ Capital Market under the ticker EDRY. EDRY is the product of a spin-off of the dry bulk fleet by Euroseas (ESEA) completed in May 2018.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • Recent preferred restructuring improves cost structure. ~$4.3 million of Series B Preferred Shares was redeemed and the dividend rate was lowered by 275 basis points through January 2021. There is a positive impact on the cost structure; the reduced dividend saves $0.54 million, or ~$212/day, and the lower Series B Preferred saves $0.41 million, or ~$163/day.
  • EuroDry stands to benefit if dry bulk market rebound extends into next year. To counteract the market weakness and reduce exposure to TCE rate volatility, Panamax forward freight agreements (FFA) were secured and effective coverage is close to…



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Research – Kelly Services (KELYA) – Initiating Coverage; A Leading Staffing Company Poised for Additional Growth

Monday, July 29, 2019

Kelly Services (KELYA)

Initiating Coverage on a Leading Staffing Company Poised for Additional Growth.

Kelly Services provides workforce solutions to a diversified group of customers in three regions: the Americas; Europe, the Middle East, and Africa (“EMEA”); and Asia Pacific (“APAC”). The customer base spans a variety of industries and includes more than 90 percent of the Fortune 100 companies. In 2018, the assigned approximately 500,000 temporary employees to a variety of customers around the globe.

Joe Gomes, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • Initiation of Coverage. We are initiating coverage of Kelly Services with an Outperform rating and $32 12-month price target. At our price target, KELYA shares would trade at 12.9x our projected 2019 EPS and 8.8x our projected EBITDA, in-line with its peer group.
  • A Market Leader. One of the pioneers of the staffing industry, Kelly is the fourth largest U.S.-based staffing firm with leading positions in…



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NOTE: investment decisions should not be based upon the content of
this research summary.  Proper due diligence is required before
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Research – Eagle Bulk Shipping (EGLE) – Convert Debt Funds Another Acquisition, Pressures Stock Price

Friday, July 26, 2019

Eagle Bulk Shipping (EGLE)

Convert Debt Funds Another Acquisition, But Pressures Stock Price.

Eagle Bulk Shipping Inc. is a US-based drybulk owner-operator focused on the Supramax/Ultramax mid-size asset class, which ranges from 50,000 and 65,000 deadweight tons in size; these vessels are equipped with onboard cranes allowing for the self-loading and unloading of cargoes, a feature which distinguishes them from the larger classes of drybulk vessels and provides for greatly enhanced flexibility and versatility- both with respect to cargo diversity and port accessibility.

Poe Fratt, Senior Research Analyst, Noble Capital Markets, Inc.

Refer to full report for price target, fundamental analysis and rating.

  • Convert debt priced yesterday despite 18% stock price drop after offering was announced. Unsecured convert debt of $100 million due in 2024 was priced with a coupon of 5% and conversion premium of 25%, or $5.61/share. Green shoe is $15 million.
  • Convert debt funds another acquisition to extend fleet renewal program. Six Ultramaxes (four built in 2015 and two in 2016) will be acquired for $122 million. There is an option to issue…



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NOTE: investment decisions should not be based upon the content of
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making any investment decision.